Dr. Lau So Ling, Caitlyn

1

Aspirin delays preterm birth in pregnancies at high risk for preterm pre-eclampsia: evidence from randomized clinical trial in Asia Leung HHY, Papastefanou I, Chen Y, Nguyen-Hoang L, Nguyen DA, Dinh LT, Pooh R K, Shiozaki A, Zheng M, Hu Y, Wu Y, Kusuma A, Yapan P, Gosavi A, Sekizawa A, Luewan S, Chang TY, Chaiyasit N, Nanthakomon T, Liu H, Shaw SW, Leung WC, Mohamad AS, Aguilar A, Lau SL, Lee NMW, Lin J, Sahota DS, Chong MKC, Poon LC Ultrasound in obstetrics & gynecology, 2025 Jul;66(1):24-32

2

Chromatin accessibility states affect transrenal clearance of plasma DNA: Implications for urine-based diagnostics Ma MJL, Zhang WZ, Jiang P, Ji L, Xiong D, Peng W, Lam WKJ, Yu SCY, Choy LYL, Tse RTH, Cheng SH, Zhou Q, Bai J, Hu X, Shi Y, Chan LL, Chan WTC, Wong PY, Fung S, Lau SL, Wong J, Chan SL, Chiu PKF, Teoh JYC, Poon LC, Ng CF, Szeto CC, Chan KCA, Lo YMD Med, 2025 Jul;6(7):100646

3

Diabetes and women's health Ma RCW, Chow EWK, Ng NYH, Sugiyama T, Deng Y, Tam WH, Lau SL, Poon LC, Zhang C, Sriram U Journal of Diabetes Investigation, 2025 Jul;16 (7):1173-1190

4

Effect of aspirin on biomarker profile in women at high risk for preeclampsia Nguyen-Hoang L, Sahota DS, Tai AST, Chen Y, Feng Q, Wang X, Moungmaithong S, Leung MBW, Tse AW, Wong NKL, Kwan AH, Lau SL, Lee NMW, Chong MKC, Poon LC American Journal of Obstetrics and Gynecology, 2025 Jun;232(6):561.e1-561.e20

5

Effect of aspirin on small for gestational age neonates in pregnancies at high-risk for preeclampsia: a secondary analysis of a cluster randomised clinical trial Chen Y, Nguyen-Hoang L, Dinh LT, Nguyen DA, Pooh R K, Shiozaki A, Zheng M, Hu Y, Ma R, Kusuma A, Wataganara T, Choolani MA, Kaneko M, Luewan S, Chang TY, Chaiyasit N, Nanthakomon T, Jiang Y, Shaw SW, Leung WC, Mohamad AS, Aguilar A, Lau SL, Lee NMW, Liu J, Sahota DS, Chong MKC, Papastefanou I, Poon LC The Lancet Regional Health - Western Pacific, 2025 Jun;59:101582

6

New first trimester circulating angiogenic biomarkers in predicting early-onset and late-onset fetal growth restriction: a case-control study Bai X, Li W, Ding W, Chan OK, Leung MBW, Lau SL, Sahota DS, Wang CC, Leung TY BMC Pregnancy Childbirth, 2025 May 10;25(1):562

7

Prediction of pre-eclampsia using maternal hemodynamic parameters at 12 + 0 to 15 + 6 weeks Wang X, Sahota DS, Wong L, Nguyen-Hoang L, Chen Y, Tai AST, Liu F, Lau SL, Lee APW, Poon LC Ultrasound Obstet Gynecol. 2025 Feb;65(2):173-182

8

First trimester cervical angles for the prediction of spontaneous preterm birth Feng Q, Chen Y, Wong JSY, Sahota DS, Lin J, Leung HHY, Wang X, Lau SL, Lee NMW, Poon LC Eur J Obstet Gynecol Reprod Biol. 2025 Jan 22:307:21-28

9

Mate-pair Sequencing Enables Identification and Delineation of Balanced and Unbalanced Structural Variants in Prenatal Cytogenomic Diagnostics Qian J, Wang H, Liang H, Zheng Y, Yu M, Tse WT, Kwan AHW, Wong L, Wong NKL, Wah IYM, Lau SL, Hui ASY, Chau MHK, Chen X, Zhang R, Poon L C, Leung TY, Liu P, Choy KW, Dong Z Clin Chem. 2025 Jan 3;71(1):155-168

10

Gestational Age-specific Reference Intervals for Androgens in Pregnancy Lau SL, Yuen LY, Ho CS, Chan MHM, Ma RCW, Tam WH J Clin Endocrinol Metab. 2024 Dec 18;110(1):176-184

11

Intermanufacturer assessment of diagnostic performance of angiogenic ratio vs glycosylated fibronectin in women with suspected pre-eclampsia Wah IYM, Sahota DS, Wong NKL, Lee NMW, Liu CJ, Lau CSL, Leung HHY, Poon LC Ultrasound Obstet Gynecol. 2024 Nov;64(5):620-625

12

Implementation of First-trimester Screening and Prevention of Preeclampsia: a Stepped Wedge Cluster-randomized Trial in Asia Nguyen-Hoang L, Dinh LT, Tai AST, Nguyen DA, Pooh RK, Shiozaki A, Zheng M, Hu Y, Li B, Kusuma RA, Yapan P, Gosavi A, Kaneko M, Luewan S, Chang TY, Chaiyasit N, Nanthakomon T, Liu H, Shaw SW, Leung WC, Mahdy ZA, Aguilar A, Leung HHY, Lee NMW, Lau SL, Wah IYM, Lu X, Sahota DS, Chong MKC, Poon LC Circulation. 2024 Oct 15;150(16):1223-1235

13

Validation of the first-trimester machine learning model for predicting pre-eclampsia in an Asian population Nguyen-Hoang L, Sahota DS, Pooh RK, Duan H, Chaiyasit N, Sekizawa A, Shaw SW, Seshadri S, Choolani M, Yapan P, Sim WS, Ma R, Leung WC, Lau SL, Lee NMW, Leung HYH, Meshali T, Meiri H, Louzoun Y, Poon LC Int J Gynaecol Obstet. 2024 Oct;167(1):350-359

14

Microbiota-targeted interventions and clinical implications for maternal-offspring health: An umbrella review of systematic reviews and meta-analyses of randomized controlled trials Alemu BK, Wu L, Azeze GG, Lau SL, Wang Y, Wang CC J Glob Health. 2024 Sep 13:14:04177

15

A point‑of‑care urine test to predict adverse maternal and neonatal outcomes in Asian women with suspected preeclampsia Wong NKL, Wah IYM, Wong STK, Nguyen-Hoang L, Lau CSL, Ip PNP, Leung HHY, Sahota DS, Poon LC Arch Gynecol Obstet. 2024 Aug;310(2):981-990

16

Implementation of sonopartogram: multicenter feasibility study Lee NMW, Lau SL, Yeung YK, Chiu CPH, Liu F, Lau YY, Fidalgo AM, Cuerva MJ, Aquise A, Nguyen-Hoang L, Gil MM, Poon LC Ultrasound Obstet Gynecol. 2024 Aug;64(2):214-221

17

Universal Targeted Haplotyping by Droplet Digital PCR Sequencing and Its Applications in Noninvasive Prenatal Testing and Pharmacogenetics Analysis Gai W, Wang G, Lam WKJ, Yuen LYP, Jiang P, Yu SCY, Leung TY, Lau SL, Lo YMD, Chan KCA Clin Chem. 2024 Aug 1;70(8):1046-1055

18

Amniotic fluid gamma-glutamyl transferase for prediction of biliary atresia in cases of non-visualisation of the fetal gallbladder: a retrospective study using a validated analytical platform and local reference rang Cheung TYT, Wong NKL, Sahota DS, Subramaniam SR, Lau SL, Zhu X, Lui WT, Chan EKW, Kwok YKY, Choy KW, Leung TY, Chan MHM, Wong FCK, Ting YH Hong Kong Med J. 2024 Jun;30(3):218-226

19

Preventive effect of prenatal maternal oral probiotic supplementation on neonatal jaundice (POPS Study): A protocol for the randomized double-blind placebo-controlled clinical trial Alemu BK, Lee MY, Leung MBW, Lee WF, Wang Y, Wang CC, Lau SL BMJ Open. 2024 Jun 8;14(6):e083641

20

Reply to Time to rethink maneuvers to resolve shoulder dystocia? Leung TY, Lau SL Am J Obstet Gynecol. 2024 Apr;230(4):e60

21

A critical evaluation of the external and internal maneuvers for resolution of shoulder dystocia Lau SL, Sin WTA, Wong L, Lee NMW, Hui SYA, Leung TY Am J Obstet Gynecol. 2024 Mar;230(3S):S1027-S1043

22

Genomic origin, fragmentomics, and transcriptional properties of long cell-free DNA molecules in human plasma Che H, Jiang P, Choy LYL, Cheng SH, Peng W, Chan RWY, Liu J, Zhou Q, Lam WKJ, Yu SCY, Lau SL, Leung TY, Wong J, Wong VW, Wong GLH, Chan SL, Chan KCA, Lo YMD Genome Res. 2024 Mar 20;34(2):189-200

23

Long-term trends in the incidence and management of shoulder dystocia in a tertiary obstetric unit in Hong Kong Chan EHL, Lau SL, Leung TY Hong Kong Med J. 2023 Dec;29(6):524-531

24

Droplet digital PCR is a cost-effective method for analyzing long cell-free DNA in maternal plasma: Application in preeclampsia Gai W, Yu SCY, Chan WTC, Peng W, Lau SL, Leung TY, Jiang P, Chan KCA, Lo YMD Prenat Diagn. 2023 Oct;43(11):1385-1393

25

Glycosylated fibronectin improves first trimester prediction of pre-eclampsia Moungmaithong S, Wang X, Lau CSL, Tse AWT, Lee NMW, Leung HHY, Poon LC, Sahota DS Ultrasound Obstet Gynecol. 2023 Oct;62(4):512-521

26

Effects of maternal probiotic supplementation on breast milk microbiome and infant gut microbiome and health: a systematic review and meta-analysis of randomized controlled trials Alemu BK, Azeze GG, Wu L, Lau SL, Wang CC, Wang Y Am J Obstet Gynecol MFM. 2023 Sep 1;5(11):101148

27

The Psychological Impacts of COVID-19 Pandemics on Pregnant Women in Hong Kong-Results of a Web-Based Cross-Sectional Survey Wong STK, Lau SL, Chiu CPH, Ip PNP, Wong L, Sys D, Kajdy A, Poon LCY Clin. Exp. Obstet. Gynecol. 2023 Jul; 50(2): 35

28

A point-of care urine test to predict preeclampsia development in Asian women with suspected preeclampsia Wong STK, Sahota DS, Wong NKL, Wah IYM, Wang X, Lau SL, Chiu CPH, Ip PNP, Poon LC Pregnancy Hypertens. 2023 Mar 30;32:28-34

29

Comparison of Single Molecule, Real-Time Sequencing and Nanopore Sequencing for Analysis of the Size, End-Motif, and Tissue-of-Origin of Long Cell-Free DNA in Plasma Yu SCY, Deng J, Qiao R, Cheng SH, Peng W, Lau SL, Choy LYL, Leung TY, Wong J, Wong VW, Wong GLH, Jiang P, Chiu RWK, Chan KCA, Lo YMD Clin Chem 2023 Feb 1;69(2):168-179

30

Neonatal outcome of infants with umbilical cord arterial pH less than 7 Lau SL, Lok ZLZ, Hui SYA, Fung GPG, Lam HS, Leung TY Acta Obstet Gynecol Scand 2023 Feb;102(2):174-180

31

Neonatal mortality in singleton pregnancies: a 20-year retrospective study from a tertiary perinatal unit in Hong Kong Fung GPG, Lau SL, Hui ASY, Wong STK, Tse WT, Ng PC, Sahota DS, Lam HS, Leung TY Hong Kong Med J. 2022 Dec;28(6):430-437

32

Dynamic changes in maternal immune biomarkers during labor in nulliparous versus multiparous women Ding W, Lau SL, Wang CC, Zhang T, Getsko O, Lee NMW, Chim SSC, Wong CK, Leung TY Am J Obstet Gynecol. 2022 Oct;227(4):627.e1-627.e23

33

Perinatal mortality rate in multiple pregnancies: a 20-year retrospective study from a tertiary obstetric unit in Hong Kong Lau SL, Wong STK, Tse WT, Fung GPG, Lam HS, Sahota DS, Leung TY Hong Kong Med J 2022 Oct;28(5):347-355

34

Stillbirth rate in singleton pregnancies: a 20-year retrospective study from a public obstetric unit in Hong Kong Wong STK, Tse WT, Lau SL, Sahota DS, Leung TY Hong Kong Med J. 2022 Aug;28(4):285-293

35

The use of ultrasound, fibronectin and other parameters to predict the success of labour induction Lau SL, Kwan A, Tse WT, Poon LC Best Pract Res Clin Obstet Gynaecol. 2022 Mar;79:27-41

36

Umbilical cord prolapse: revisiting its definition and management Wong L, Kwan AHW, Lau SL, Sin WTA, Leung TY Am J Obstet Gynecol. 2021 Oct;225(4):357-366

37

Molecular mechanism and pathways of normal human parturition in different gestational tissues: a systematic review of transcriptome studies Ding W, Chim SSC, Wang CC, Lau CSL, Leung TY Front Oncol. 2021 Sep 10;12:730030

38

Characteristics of Fetal Extrachromosomal Circular DNA in Maternal Plasma: Methylation Status and Clearance Sin STK, Ji L, Deng J, Jiang P, Cheng SH, Heung MMS, Lau CSL, Leung TY, Chan KCA, Chiu RWK, Lo YMD Clin Chem. 2021 Apr 29;67(5):788-796

39

Allelic Imbalance at 13q31 is Associated with Reduced GPC6 in Chinese with Sporadic Retinoblastoma. Lau CSL, Yu CBO, Wong HK, Fan DSP, Mak HT, Wong KW, Lam DSC, Pang CCP, Choy KW Br J Ophthalmol 2010;94(3): 357 - 363

40

Epigenetic Regulation of Neonatal Cardiomyocytes Differentiation. Kou CYC, Lau SLC, Au KW, Leung PY, Chim SSC, Fung KP, Waye MMY, Tsui SKW Biochem Bioph Res Co 2010;400(2): 278 - 283

41

Prenatal Screening for Retinoblastoma in Hong Kong. Lau CSL, Choy KW, Fan DSP, Yu CBO, Wong CY, Lam DSC, Pang CCP Hong Kong Med J 2008;14(5): 391 - 394