The selected publications  in prenatal genetic diagnosis, preterm birth, fetal growth restriction, and fetal therapy. 

1

Genetic screening in patients with ovarian dysfunction

Zeng Y, Li L, Li Q, Hu J, Zhang N, Wu L, Yan Z, Qu R, Dong J, Liu R, Choy KW, Wang L, Sang Q, Guan Y, Chen B

Clin Genet. 2023 Mar;103(3):352-357

2

TEDD: a database of temporal gene expression patterns during multiple developmental periods in human and model organisms

Zhou Z, Tan C, Chau MHK, Jiang X, Ke Z, Chen X, Cao Y, Kwok YK, Bellgard M, Leung TY, Choy KW, Dong Z

Nucleic Acids Res. 2023 Jan 6;51(D1):D1168-D1178

3

The Sperm Small RNA Transcriptome: Implications beyond Reproductive Disorder

Chan SY, Wan CWT, Law TYS, Chan DYL, Fok EKL

Int J Mol Sci. 2022 Dec 11;23(24):15716

4

Implementation of public funded genome sequencing in evaluation of fetal structural anomalies

So PL, Hui ASY, Ma TWL, Shu W, Hui APW, Kong CW, Lo TK, Kan ANC, Kan EYL, Chong SC, Chung BHY, Luk HM, Choy KW, Kan ASY, Leung WC

Genes (Basel). 2022 Nov 10;13(11):2088

5

Genome-Wide Cell-Free DNA Test for Fetal Chromosomal Abnormalities and Variants: Unrestricted Versus Restricted Reporting

Kwan AHW, Zhu X, Mar Gil M, Kwok YKY, Wah IYM, Hui ASY, Ting YH, Law KM, Lau D, Xue S, Choy KW, Sahota D, Leung TY, Poon LC

Diagnostics (Basel). 2022 Oct 9;12(10):2439

6

Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes

Pervjakova N, Moen GH, Borges MC, Ferreira T, Cook JP, Allard C, Beaumont RN, Canouil M, Hatem G, Heiskala A, Joensuu A, Karhunen V, Kwak SH, Lin FTJ, Liu J, Rifas-Shiman S, Tam CH, Tam WH, Thorleifsson G, Andrew T, Auvinen J, Bhowmik B, Bonnefond A, Delahaye F, Demirkan A, Froguel P, Haller-Kikkatalo K, Hardardottir H, Hummel S, Hussain A, Kajantie E, Keikkala E, Khamis A, Lahti J, Lekva T, Mustaniemi S, Sommer C, Tagoma A, Tzala E, Uibo R, Vääräsmäki M, Villa PM, Birkeland KI, Bouchard L, Duijn CM, Finer S, Groop L, Hämäläinen E, Hayes GM, Hitman GA, Jang HC, Järvelin MR, Jenum AK, Laivuori H, Ma RC, Melander O, Oken E, Park KS, Perron P, Prasad RB, Qvigstad E, Sebert S, Stefansson K, Steinthorsdottir V, Tuomi T, Hivert MF, Franks PW, McCarthy MI, Lindgren CM, Freathy RM, Lawlor DA, Morris AP, Mägi R

Hum Mol Genet. 2022 Sep 29;31(19):3377-3391

7

Editorial: Chromosome structural variants: Epidemiology, identification and contribution to human diseases

Dong Z, David D, Gonzaga-Jauregui C, Morton CC, Zepeda-Mendoza CJ

Front Genet. 2022 Sep 9;13:1022918

8

Investigation of the genetic etiology in male infertility with apparently balanced chromosomal structural rearrangements by genome sequencing

Chau MHK, Li Y, Dai P, Shi M, Zhu X, Chung JPW, Kwok YK, Choy KW, Kong X, Dong Z

Asian J Androl. May-Jun 2022;24(3):248-254

9

The Burden and Benefits of Knowledge: Ethical Considerations Surrounding Population-Based Newborn Genome Screening for Hearing

Mitchell CO, Rivera-Cruz G, Chau MHK, Dong Z, Choy KW, Shen J, Amr S, Giersch ABS, Morton CC

Int J Neonatal Screen. 2022 May 27;8(2):36

10

Investigation of chromosomal structural abnormalities in patients with undiagnosed neurodevelopmental disorders

Cao Y, Luk HM, Zhang YY, Chau MHK, Xue S, Cheng SSW, Li AM, Chong JSC, Leung TY, Dong Z, Choy KW, Lo IFM

Front Genet. 2022 Apr 14;13:803088

11

Experience of Low-Pass Whole-Genome Sequencing-Based Copy Number Variant Analysis: A Survey of Chinese Tertiary Hospitals

Zheng Y, Zhu B, Tan J, Guan Y, The Chinese Genomic Structural Variants Consortium, Morton CC, Lu G

Diagnostics 2022 Apr, 12(5), 1098

12

Whole Genome Transcriptomic Analysis of Ovary Granulosa Cells Revealed an Anti-Apoptosis Regulatory Gene DLGAP5 in Polycystic Ovary Syndrome

Deng Y, Li H, Song Y, Cen J, Zhang Y, Sui Y, Cui D, Li TC, Xu Y, Wang CC, Chung PWJ, Tang T

Front Endocrinol (Lausanne). 2022 Mar 18;13:781149

13

Whole-genome sequencing of genetically undiagnosed euploid fetuses with increased nuchal translucency: abridged secondary publication

Choy RKW, Cao Y, Lo FM, Cheung SW, Yang Y, Leung TY

Hong Kong Med J. 2022 Feb;28 Suppl 1(1):8-10

14

Contributions of common genetic variants to specific languages and to when a language is learned

Wong PCM, Kang X, So HC, Choy KW

Sci Rep. 2022 Jan 12;12(1):580

15

Single-molecule sequencing reveals a large population of long cell-free DNA molecules in maternal plasma

Yu SCY, Jiang P, Peng W, Cheng SH, Cheung YTT, Tse OYO, Shang H, Poon LC, Leung TY, Chan KCA, Chiu RWK, Lo YMD

Proc Natl Acad Sci U S A. 2021 Dec 14;118(50):e2114937118

16

SVInterpreter: A Comprehensive Topologically Associated Domain-Based Clinical Outcome Prediction Tool for Balanced and Unbalanced Structural Variants

Fino J, Marques B, Dong Z, David D

Front Genet. 2021 Dec 1;12:757170

17

Chromosomal abnormalities and neurological outcomes in fetal cerebral ventriculomegaly: a retrospective cohort analysis

Lok WY, Kong CW, Hui SYA, Shi MM, Choy KW, To WK, Leung TY

Hong Kong Med J. 2021 Dec;27(6):428-436

18

Adaptive risk prediction system with incremental and transfer learning

Koivu A, Sairanen M, Airola A, Pahikkala T, Leung WC, Lo TK, Sahota DS

Comput Biol Med. 2021 Nov;138:104886

19

Trio-Based Low-Pass Genome Sequencing Reveals Characteristics and Significance of Rare Copy Number Variants in Prenatal Diagnosis

Chau MHK, Qian J, Chen Z, Li Y, Zheng Y, Tse WT, Kwok YK, Leung TY, Dong Z, Choy KW

Front Genet. 2021 Sep 20;12:742325

20

A Fetus with Congenital Microcephaly, Microphthalmia and Cataract Was Detected with Biallelic Variants in the OCLN Gene: A Case Report

Ng VKS, Lau TK, Kan ASY, Chung BHY, Luk HM, Ng WF, Shi M, Choy KW, Cao Y, Leung WC

Diagnostics 2021 Aug;11(9): 1576

21

Low-pass genome sequencing-based detection of absence of heterozygosity: validation in clinical cytogenetics

Dong Z, Chau MHK, Zhang Y, Yang Z, Shi M, Wah YMI, Kwok YK, Leung TY, Morton C, Choy KW

Genet Med. 2021 Jul;23(7):1225-1233

IF

N/A

M

6.897

Rank%

8.683

22

Characteristics of Fetal Extrachromosomal Circular DNA in Maternal Plasma: Methylation Status and Clearance

Sin STK, Ji L, Deng J, Jiang P, Cheng SH, Heung MMS, Lau CSL, Leung TY, Chan KCA, Chiu RWK, Lo YMD

Clin Chem. 2021 Apr 29;67(5):788-796

23

The role of chromosomal microarray and exome sequencing in prenatal diagnosis

Chau MHK, Choy KW

Curr Opin Obstet Gynecol. 2021 Apr 1;33(2):148-155

24

Applications of genetic-epigenetic tissue mapping for plasma DNA in prenatal testing, transplantation and oncology

Gai W, Zhou Z, Agbor-Enoh S, Fan X, Lian S, Jiang P, Cheng SH, Wong J, Chan SL, Jang MK, Yang Y, Liang RH, Chan WK, Ma ES, Leung TY, Chiu RW, Valantine H, Chan KA, Lo YD

Elife. 2021 Mar 23;10:e64356

25

Clinical utility of expanded non-invasive prenatal screening and chromosomal microarray analysis in high-risk pregnancy

Zhu X, Chen M, Wang H, Guo Y, Chau MHK, Yan H, Cao Y, Kwok YKY, Chen J, Hui ASY, Zhang R, Meng Z, Zhu Y, Leung TY, Xiong L, Kong X, Choy KW

Ultrasound Obstet Gynecol. 2021 Mar;57(3):459-465

26

First Case Report of Maternal Mosaic Tetrasomy 9p Incidentally Detected on Non-Invasive Prenatal Testing

Shu W, Cheng SSW, Xue S, Chan LW, Soong SI, Kan ASY, Cheung SWH, Choy KW

Genes 2021 Mar;12(3): 12030370

27

Performance of Cell-Free DNA Screening for Fetal Common Aneuploidies and Sex Chromosomal Abnormalities: A Prospective Study from a Less Developed Autonomous Region in Mainland China

Lai Y, Zhu X, He S, Dong Z, Tang Y, Xu F, Chen Y, Meng L, Tao Y, Yi S, Su J, Huang H, Luo J, Leung TY, Wei H

Genes 2021 Mar;12(4):12040478

28

Deciphering the complexity of simple chromosomal insertions by genome sequencing

Dong Z, Chau MHK, Zhang Y, Dai P, Zhu X, Leung TY, Kong X, Kwok YK, Stankiewicz P, Cheung SW, Choy KW

Hum Genet. 2021 Feb;140(2):361-380

29

The role of chromosomal microarray analysis among fetuses with normal karyotype and single system anomaly or nonspecific sonographic findings

Hui ASY, Chau MHK, Chan YM, Cao Y, Kwan AHW, Zhu X, Kwok YKY, Chen Z, Lao TTH, Choy KW, Leung TY

Acta Obstet Gynecol Scand. 2021 Feb;100(2):235-243

30

Detection and characterization of jagged ends of double-stranded DNA in plasma

Jiang P, Xie T, Ding SC, Zhou Z, Cheng SH, Chan RWY, Lee WS, Peng W, Wong J, Wong VWS, Chan HLY, Chan SL, Poon LCY, Leung TY, Chan KCA, Chiu RWK, Lo YMD

Genome Res. 2020 Aug;30(8):1144-1153

31

Clinical Significance of Non-Invasive Prenatal Screening for Trisomy 7: Cohort Study and Literature Review

Zhu X, Lam DYM, Chau MHK, Xue S, Dai P, Zhao G, Cao Y, Cheung SWH, Kwok YKY, Choy KW, Kong X, Leung TY

Genes (Basel). 2020 Dec 24;12(1):E11

32

Noninvasive prenatal sequencing for multiple Mendelian monogenic disorders among fetuses with skeletal dysplasia or increased nuchal translucency

Yan H, Zhu X, Chen J, Cao Y, Kwok YKY, Chen Z, Leung TY, Chen M, Choy KW

Prenat Diagn. 2020 Oct;40(11):1459-1465

33

The utility of genome-wide cell-free DNA screening in the prenatal diagnosis of Pallister-Killian syndrome

Chau MHK, Lam YKD, Zhu X, Kwok YKY, Ting YH, Chan WP, Shi M, Cheung WH, Lau TK, Ville Y, Leung TY, Choy KW

Prenat Diagn. 2020 Jul;40(8):1005-1012

IF

N/A

M

35.37

Rank%

2.425

34

Low-pass genome sequencing versus chromosomal microarray analysis: implementation in prenatal diagnosis

Wang H, Dong Z, Zhang R, Chau MHK, Yang Z, Tsang K, Wong HK, Gui B, Meng Z, Xiao K, Zhu X, Wang Y, Chen S, Leung TY, Cheung SW, Kwok YK, Morton CC, Zhu Y, Choy KW

Genet Med, 2020 Mar;22(3):500-510

35

Recent Advances in the Noninvasive Prenatal Testing for Chromosomal Abnormalities Using Maternal Plasma DNA

Lau TK, Zhu X, Kwok YKY, Leung TY, Choy KW

Journal of Fetal Medicine, 2020 Mar;7(1):17-23

36

Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin

Sun K, Jiang P, Cheng SH, Cheng THT, Wong J, Wong VWS, Ng SSM, Ma BBY, Leung TY, Chan SL, Mok TSK, Lai PBS, Chan HLY, Sun H, Chan KCA, Chiu RWK, Lo YMD

Genome Res. 2019 Mar;29(3):418-427

37

Clinical utility of noninvasive prenatal screening for pathogenic copy number variants REPLY

Chau MHK, Sahota DS, Choy KW

Am J Obstet Gynecol. 2019 Dec;221(6):661-662.

38

Prenatal Diagnosis of Fetuses with Increased Nuchal Translucency by Genome Sequencing Analysis

Choy KW, Wang H, Shi M, Chen J, Yang Z, Zhang R, Yan H, Wang Y, Chen S, Chau MHK, Cao Y, Chan OYM, Kwok YKY, Zhu Y, Chen M, Leung TY, Dong Z

Front Genet. 2019 Aug; volume 10:761 (14 pages)

39

Prenatal diagnosis of pathogenic genomic imbalance in fetuses with increased nuchal translucency but normal karyotyping using chromosomal microarray

Leung TY, Au Yeung KC, Leung WC, Leung KY, Lo TK, To WWK, Lau WL, Chan LW, Sahota DS, Choy KW

Hong Kong Med J. 2019 Aug;25 Suppl 5(4):30-32

40

Publisher Correction: Non-invasive prenatal sequencing for multiple Mendelian monogenic disorders using circulating cell-free fetal DNA

Zhang J, Li J, Saucier JB, Feng Y, Jiang Y, Sinson J, McCombs AK, Schmitt ES, Peacock S, Chen S, Dai H, Ge X, Wang G, Shaw CA, Mei H, Breman A, Xia F, Yang Y, Purgason A, Pourpak A, Chen Z, Wang X, Wang Y, Kulkarni S, Choy KW, Wapner RJ, Van den Veyver IB, Beaudet A, Parmar S, Wong LJ, Eng CM

Nat Med. 2019 Apr;25(4):701-702

41

Non-invasive prenatal sequencing for multiple Mendelian monogenic disorders using circulating cell-free fetal DNA

Zhang J, Li J, Saucier JB, Feng Y, Jiang Y, Sinson J, McCombs AK, Schmitt ES, Peacock S, Chen S, Dai H, Ge X, Wang G, Shaw CA, Mei H, Breman A, Xia F, Yang Y, Purgason A, Pourpak A, Chen Z, Wang X, Wang Y, Kulkarni S, Choy KW, Wapner RJ, Van den Veyver IB, Beaudet A, Parmar S, Wong LJ, Eng CM

Nat Med. 2019 Mar;25(3):439-447

42

Characteristics and mode of inheritance of pathogenic copy number variants in prenatal diagnosis

Chau MHK, Cao Y, Kwok YKY, Chan S, Chan YM, Wang H, Yang Z, Wong HK, Leung TY, Choy KW

American Journal of Obstetrics and Gynecology 2019;221(5):493e1-e11.

43

Size-tagged preferred ends in maternal plasma DNA shed light on the production mechanism and show utility in noninvasive prenatal testing

Sun K, Jiang P, Wong AIC, Cheng YKY, Cheng SH, Zhang H, Chan KCA, Leung TY, Chiu RWK, Lo YMD

Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5106-E5114

44

Noninvasive reconstruction of placental methylome from maternal plasma DNA: Potential for prenatal testing and monitoring

Sun K, Lun FMF, Leung TY, Chiu RWK, Lo YMD, Sun H

Prenat Diagn. 2018 Feb;38(3):196-203

45

Identification of balanced chromosomal rearrangements previously unknown among participants in the 1000 Genomes Project: implications for interpretation of structural variation in genomes and the future of clinical cytogenetics

Dong Z, Wang H, Chen H, Jiang H, Yuan J, Yang Z, Wang WJ, Xu F, Guo X, Cao Y, Zhu Z, Geng C, Cheung CWC, Kwok YKY, Yang H, Leung TY, Morton CC, Cheung SW, Choy KW

Genet Med. 2018 Jul;20(7):697-707

46

Women’s preference for non-invasive prenatal DNA testing versus chromosomal microarray after screening for Down syndrome: a prospective study

Cheng YKY, Leung WC, Leung TY, Choy KW, Chiu RWK, Lo TK, Kwok YKY, Sahota DS

BJOG. 2018 Mar;125(4):451-459

47

Balanced Chromosomal Rearrangement Detection by Low-Pass Whole-Genome Sequencing

Dong Z, Ye L, Yang Z, Chen H, Yuan J, Wang H, Guo X, Li Y, Wang J, Chen F, Cheung SW, Morton CC, Jiang H, Choy KW

Curr Protoc Hum Genet. 2018 Jan 24;96:8.18.1-8.18

48

Obstetric professionals' perceptions of non-invasive prenatal testing for Down syndrome: clinical usefulness compared with existing tests and ethical implications

Ngan OMY, Yi H, Wong SYS, Sahota DS, Ahmed S

BMC Pregnancy Childbirth. 2017 Sep 5;17(1):285

49

Gestational Age Assessment by Methylation and Size Profiling of Maternal Plasma DNA: A Feasibility Study

Jiang P, Tong YK, Sun K, Cheng SH, Leung TY, Allen Chan KC, Chiu RW, Ming Dennis Lo Y

Clin Chem. 2017 Feb;63(2):606-608

50

Universal Haplotype-Based Noninvasive Prenatal Testing for Single Gene Diseases

Hui WW, Jiang P, Tong YK, Lee WS, Cheng YKY, New MI, Kadir RA, Chan KC, Leung TY, Lo YM, Chiu RW

Clin Chem Feb 2017 ;63(2):513-524

51

Chromosome copy number variants in fetuses with syndromic malformations

Wang H, Chau MHK, Cao Y, Kwok KY, Choy KW

Birth Defects Res. Jun 2017 ;109(10):725-733

52

Identification of fragile X pre-mutation carriers in the Chinese obstetric population using a robust FMR1 polymerase chain reaction assay: implications for screening and prenatal diagnosis

Cheng Y KY , Lin CSW, Kwok YKY, Chan OYM , Lau TK , Leung TY , Choy KW

Hong Kong Med J. 2017 Apr;23(2):110-6

53

Combined Count- and Size-Based Analysis of Maternal Plasma DNA for Noninvasive Prenatal Detection of Fetal Subchromosomal Aberrations Facilitates Elucidation of the Fetal and/or Maternal Origin of the Aberrations

Yu SC, Jiang P, Allen Chan KC, Faas BH, Choy KW, Leung WC, Leung TY, Dennis Lo YM, Chiu RW

Clin Chem. 2017 Feb;63(2):495-502

54

Applicability of first-trimester combined screening for fetal trisomy 21 in a resource-limited setting in mainland China

Li B, Sahota DS, Lao TT, Xu J, Hu SQ, Zhang L, Liu QY, Sun Q, Tang D, Ma RM

BJOG: An International Journal of Obstetrics and Gynaecology Sep 2016 123( S3): 23-29

55

Prenatal detection of 10q22q23 duplications: dilemmas in phenotype prediction

Kong GWS, Cao Y, Huang J, Cheng KY, Pursley AN, Rosenfeld JA, Edwards J G, Chan YM, Cheung SW, Leung TY, Choy KW

Prenat Diagn. 2016 Dec;36(13):1211-1216

56

Second Generation Noninvasive Fetal Genome Analysis Reveals De Novo Mutations, Single-Base Parental Inheritance, and Preferred DNA Ends

Chan KC, Jiang P, Sun K, Cheng YKY, Tong YK, Cheng SH, Wong AI, Hudecova I, Leung TY, Chiu RW, Lo YM

Proc Natl Acad Sci U S A Dec 2016;113(50):E8159-E8168

57

Low-pass Whole-genome Sequencing in Clinical Cytogenetics: A Validated Approach

Dong Z, Zhang J, Hu P, Chen H, Xu J, Tian Q, Meng L, Ye Y, Wang J, Zhang M, Li Y, Wang HL, Yu S, Chen F, Xie J, Jiang H, Wang W, Choy KW, Xu Z

Genet Med Sep 2016;18(9): 940 - 948

58

A γA-Crystallin Mouse Mutant Secc with Small Eye, Cataract and Closed Eyelid.

Cheng MH, Tam CN, Choy KW, Tsang WH, Tsang SL, Pang CCP, Song YQ, Sham MH

PLos ONE Aug 2016;11(8): e0160691 (1 - 15)

59

Clinical implementation of routine screening for fetal trisomies by the cell-free DNA test contingent on results from first-trimester combined test.

Gil MM, Revello R, Poon LC, Akolekar R, Nicolaides KH.

Ultrasound Obstet Gynecol 2016; 47:45-52.

60

Clinical validation of the ION test for first-trimester detection of trisomy 21, 18 and 13.

Poon LC, Dumidrascu-Diris D, Francisco C, Fantasia I, Nicolaides KH.

Ultrasound Obstet Gynecol 2016; 47:184-187

61

Current controversies in prenatal diagnosis 3: Is there still a Value in a Nuchal Translucency Screening Ultrasound in conjunction with Maternal Plasma Non-Invasive cell free DNA testing

Wilson RD, Poon LC, and Ghidini A.

Prenatal Diagnosis 2015; doi: 10.1002/pd.4719. [Epub ahead of print_]

62

Rubella Seronegativity in Antenatal Screening - Is It Influenced by the Introduction of Universal Childhood Rubella Immunization?

Lao TTH, Sahota DS, Law LW, Leung TY

Vaccine 2015;33(38): 4776 - 4781

63

UK NHS pilot study on cell-free DNA testing in screening for fetal trisomies: Factors affecting uptake.

Gil MM, Giunta G, Macalli EA, Poon LC, Nicolaides KH.

Ultrasound Obstet Gynecol 2015; 45: 67-73.

64

Diagnostic accuracy of the BACs-on-Beads™ assay versus karyotyping for prenatal detection of chromosomal abnormalities: a retrospective consecutive case series.

Choy K, Kwok Y, Cheng Y, Wong K, Wong H, Leung K, Suen K, Adler K, Wang C, Lau T, Schermer M, Lao T, Leung TY.

BJOG 2014; 121:1245-52.

65

Genetic Diagnosis of Autism Spectrum Disorders: The Opportunity and Challenge in the Genomics Era.

Jiang YH, Wang Y, Xiu X, Choy KW, Pursley AN, Cheung SW

Crit Rev Clin Lab Sci 2014;51(5): 249 - 262

66

Is High Fetal Nuchal Translucency Associated with Submicroscopic Chromosomal Abnormalities by Array CGH?

Huang J, Poon LC, Akolekar R, Choy KW, Leung TY, Nicolaides KH.

Ultrasound Obstet Gynecol 2014; 43: 620-624.

67

Non-Invasive Prenatal Testing for Fetal Chromosomal Abnormalities by Low-Coverage Whole-Genome Sequencing of Maternal Plasma DNA: Review of 1982 Consecutive Cases in a Single Center.

Lau TK, Cheung SW, Lo PSS, Pursley AN, Chan MK, Jiang F, Zhang H, Wang W, Jong LFJ, Yuen OKC, Chan HYC, Chan WSK, Choy KW

Ultrasound Obst Gyn 2014;43(3): 254 - 264

68

First-trimester contingent screening for trisomies 21, 18 and 13 by biomarkers and maternal blood cell-free DNA testing.

Nicolaides KH, Syngelaki A, Poon LC, Gil M, Wright D.

Fetal Diagn Ther 2014; 35: 185-192.

69

Potential application of fetal epigenetic markers on the non-invasive prenatal detection of chromosomal abnormality.

Chim SSC

Clin Chem Lab Med 2014;52(5): 585 - 588

70

Meta-analysis of second-trimester markers for trisomy 21.

Agathokleous M, Chaveeva P, Poon LC, Kosinski P, Nicolaides KH.

Ultrasound Obstet Gynecol 2013; 41: 247-261.

71

Noninvasive Prenatal Determination of Twin Zygosity by Maternal Plasma DNA Analysis.

Qu JZZ, Leung TY (co-1st author), Jiang P, Liao GJW, Cheng YKY, Sun H, Chiu RWK, Chan KCA, Lo YM.

Clin Chem 2013; 59:427-35.

72

Noninvasive Twin Zygosity Assessment and Aneuploidy Detection by Maternal Plasma DNA Sequencing.

Leung TY, Qu JZZ, Liao GJW, Jiang PY, Cheng YKY, Chan AKC, Chiu RWK, Lo DYM

Prenatal Diag 2013;33(7): 675 - 681

73

Prospective Assessment of the Hong Kong Hospital Authority Universal Down Syndrome Screening Programme.

Sahota DS, Leung WC, Chan WP, To WWK, Lau ET, Leung TY

Hong Kong Med J 2013;19(2): 101 - 108

74

Second-trimester screening for trisomy 21 using prefrontal space ratio.

Chaveeva P, Agathokleous M, Poon LC, Markova D, Nicolaides KH.

Fetal Diagn Ther 2013; 34: 50-55.

75

Prenatal Detection of Aneuploidy and Imbalanced Chromosomal Arrangements by Massively Parallel Sequencing.

Dan S, Chen F, Choy KW, Jiang FM, Lin JR, Xuan ZL, Wang W, Chen SP, Li XC, Jiang H, Leung TY, Lau TK, Su Y, Zhang WY, Zhang XQ

PLos ONE 2012;7(2): e27835

76

Identification of Submicroscopic Chromosomal Aberrations in Fetuses with increased Nuchal Translucency and Apparently Normal Karyotype.

Leung TY, Vogel I, Lau TK, Chong WS, Hyett JA, Petersen OB, Choy KW

Ultrasound Obst Gyn 2011;38(3): 314 - 319

77

Non-Invasive Prenatal Assessment of Trisomy 21 by Multiplexed Maternal Plasma DNA Sequencing : Large Scale Validity Study.

Chiu RWK, Akolekar R, Zheng YWL, Leung TY, Sun H, Chan AKC, Lun FMF, Go ATJI, Lau ET, To WWK, Leung WC, Tang RYK, Au Yeung KC, Lam H, Kung YY, Zhang XQ, Van Vugt JMG, Minekawa R, Tang MHY, Wang J, Oudejans CBM, Lau TK, Nicolaides KH, Lo DYM

Brit Med J 2011;342: c7401

78

Noninvasive Prenatal Diagnosis of Fetal Trisomy 18 and Trisomy 13 by Maternal Plasma DNA Sequencing.

Chen EZ, Chiu RWK, Sun H, Akolekar R, Chan AKC, Leung TY, Jiang PY, Zheng YWL, Lun FMF, Chan LYS, Jin YJ, Go ATJI, Lau ET, To WWK, Leung WC, Tang RYK, Au Yeung KC, Lam H, Kung YY, Wang J, Van Vugt JMG, Minekawa R, Tang MHY, Wang J, Oudejans CBM, Lau TK, Nicolaides KH, Lo DYM

PLos ONE 2011;6(7): e21791

79

採用微陣列 - 比較基因組雜交進行產前診斷的局限性和困難

Chen Y, Choy KW

中華醫學遺傳學雜誌,2011(1):47-51

80

Comparison of First-Trimester Contingent Screening Strategies for Down Syndrome.

Sahota DS, Leung TY, Chan LW, Law LW, Fung TY, Chen M, Lau TK

Ultrasound Obst Gyn 2010;35(3): 286 - 291

81

Epigenetic-Genetic Chromosome Dosage Approach for Fetal Trisomy 21 Detection Using an Autosomal Genetic Reference Marker.

Tong YK, Chiu RWK, Akolekar R, Leung TY, Lau TK, Nicolaides KH, Lo DYM

PLos ONE 2010;5(12): e15244

82

Systematic Identification of Placental Epigenetic Signatures for the Noninvasive Prenatal Detection of Edwards Syndrome.

Tsui DWY, Lam DYM, Lee CWS, Leung TY, Lau TK, Lau ET, Tang MHY, Akolekar R, Nicolaides KH, Chiu RWK, Lo DYM, Chim SSC

PLos ONE 2010;5(11): e15069

83

The Impact of Human Copy Number Variation on a New Era of Genetic Testing.

Choy KW, Setlur SR, Lee C, Lau TK

BJOG 2010;117(4): 391 - 398

84

先天性心臟病患兒22q11微缺失的定量螢光聚合酶鏈反應檢測

Chen Y, Mao J, Kwok YKY, Kan HJ, Li HB, Liu MJ, Sun Y, Yan WH, Li H, Choy KW

中華醫學遺傳學雜誌, 2010(5):5

85

先天性心臟病患兒22q11微缺失的定量螢光聚合酶鏈反應檢測22q11 Microdeletion Test in Patients with Congenital Heart Defects by Quantitative Fluorescent PCR.

Chen Y, Mao J, Kwok YKY, Kan HJ, Li HB, Liu MJ, Sun Y, Yan WH, Li H, Choy KW

Chin J Med Genet 2010;27(5): 571 - 575

86

唐氏綜合征的產前篩查模式和臨床應用.

Lau TK, Leung TY, Chen M, Liao C

Chin J Obstet Gynecol 2010;45(6)

87

唐氏綜合症的產前診斷.

Lau TK, Leung TY, Chen M, Liao C

Chin J Obstet Gynecol 2010;45(10): 732 - 734

88

Antenatal taboos among Chinese women in Hong Kong.

Lee DTS, Ngai ISL, Ng MMT, Lok IH, Yip SK, Chung TKH

Midwifery 2009;25(2): 104 - 113

89

Chinese women's preferences for prenatal diagnostic procedure and their willingness to trade between procedures.

Chan OYM, Sahota DS, Leung TY, Choy KW, Chan OK, Lau TK

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90

De novo 16p13.11 microdeletion identified by high-resolution array CGH in a fetus with increased nuchal translucency.

Law LW, Lau TK, Fung TY, Leung TY, Wang CC, Choy KW

BJOG 2009;116(2): 339 - 343

91

Detection of cryptic pathogenic copy number variations and constitutional loss of heterozygosity using high resolution SNP microarray analysis in 117 patients referred for cytogenetic analysis and impact on clinical practice.

Bruno DL, Ganesamoorthy D, Schoumans J, Bankier A, Coman D, Delatycki M, Gardner RJM, Hunter M, James PA, Kannu P, McGillivray G, Pachter N, Peters H, Rieubland C, Savarirayan R, Scheffer IE, Sheffield L, Tan T, White SM, Yeung A, Bowman Z, Ngo C, Choy KW, Cacheux V, Wong L, Amor DJ, Slater HR

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92

First Trimester Combined Screening for Trisomy 21 in Hong Kong: Outcome of the First 10000 Cases.

Leung TY, Chan LW, Law LW, Sahota DS, Fung TY, Leung TN, Lau TK

J Matern Fetal Neonatal Med 2009;22(4): 300 - 304

93

Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: Associations with Neonatal Anthropometrics.

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Diabetes 2009;58(2): 453 - 459

94

Maternal serum ADAM12 (A Disintegrin And Metalloprotease) in chromosomally abnormal pregnancies at 11+0-13+6 weeks.

Poon LC, Chelemen T, Minekawa R, Frisova V, Nicolaides KH.

American Journal Obstetrics and Gynecology 2009; 200: 508.e1-6.

95

Monozygotic Dichorionic Twins Heterokaryotypic for Duplication Chromosome 2q13-q23.3.

Leung WC, Choi H, Lau WL, Ng LKI, Lau ET, Lo FM, Choy KW, Lau TK, Tang MHY, Chin RKH

Fetal Diagn Ther 2009;25(4): 397 - 399

96

Non-invasive Prenatal Detection of Fetal Trisomy 18 by RNA-SNP Allelic Ratio Analysis Using Maternal Plasma SERPINB2 mRNA: a Feasibility Study.

Tsui NBY, Wong CK, Leung TY, Lau TK, Chiu RWK, Lo DYM

Prenatal Diag 2009;29(11): 1031 - 1037

97

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Lau TK, Leung TY

JPOG 2009;35(3): 125 - 131

98

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Heung MS, Jin SN, Tsui NBY, Ding CM, Leung TY, Lau TK, Chiu Rossa WK, Lo DYM

PLos ONE 2009;4(6): e5858

99

Prenatal findings and delineation of de novo concurrent partial trisomy 7q(7q31.2 --> qter) and partial monosomy 6q(6q26 --> qter) by high-resolution array CGH.

Choy KW, Chan LW, Tang MHY, Ng LKI, Leung TY, Lau TK

J Matern Fetal Neonatal Med 2009;22(11): 1014 - 1020

100

Study on the applicability of frontomaxillary facial angle in the first-trimester trisomy 21 fetuses in Chinese population.

Chen M, Yang X, Leung TY, Sahota DS, Fung TY, Chan LW, Lao TTH, Lau TK

Prenatal Diag 2009;29(12): 1141 - 1144

101

First trimester maternal serum A Disintegrin And Metalloprotease 12 and adverse pregnancy outcome.

Poon LC, Chelemen T, Granvillano O, Pandeva I, Nicolaides KH.

Obstetric Gynecol 2008; 112: 1082-1090.

102

Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma.

Chiu Rossa WK, Chan AKC, Gao Y, Lau VYM, Zheng W, Leung TY, Foo CHF, Xie B, Tsui NBY, Lun FMF, Zee BCY, Lau TK, Cantor CR, Lo DYM

Proc Natl Acad Sci USA 2008;105(51): 20458 - 20463

103

Noninvasive prenatal diagnosis of monogenic diseases by digital size selection and relative mutation dosage on DNA in maternal plasma.

Lun FMF, Tsui NBY, Chan AKC, Leung TY, Lau TK, Charoenkwan P, Chow KCK, Lo WYW, Wanapirak C, Sanguansermsri T, Cantor CR, Chiu Rossa WK, Lo DYM

Proc Natl Acad Sci USA 2008;105(50): 19920 - 19925

104

Screening for Trisomy 21 by Maternal Age, Fetal Nuchal Translucency Thickness, Free Beta-Human Chorionic Gonadotropin and Pregnancy-Associated Plasma Protein-A.

Kagan KO, Wright D, Baker A, Sahota DS, Nicolaides KH

Ultrasound Obst Gyn 2008;31(6): 618 - 624

105

The Application of Microarray Based Comparative Genomic Hybridization in Prenatal Diagnosis.

Choy KW, Tsang PT, Leung TY, Wang CC, Lau TK

Fetal and Maternal Medicine Review 2008;19(2): 119 - 133

106

Digital PCR for the molecular detection of fetal chromosomal aneuploidy.

Lo DYM, Lun FMF, Chan AKC, Tsui NBY, Chong KC, Lau TK, Leung TY, Zee BCY, Cantor CR, Chiu Rossa WK

Proc Natl Acad Sci USA 2007;104(32): 13116 - 13121

107

Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection.

Lo DYM, Tsui NBY, Chiu Rossa WK, Lau TK, Leung TN, Heung MS, Gerovassili A, Jin Yongjie, Nicolaides KH, Cantor CR, Ding CM

Natl Med J China 2007;13(2): 218 - 223

108

Genome-wide gene expression profiling of cervical cancer in Hong Kong women by oligonucleotide microarray.

Wong YF, Cheung TH, Tsao GSW, Lo KWK, Yim SF, Wang VW, Heung MS, Chan CS, Chan LKY, Ho TWF, Wong KWY, Li C, Guo Y, Chung TKH, Smith DI

Int J Cancer 2006;118(10): 2461 - 2469

109

Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes.

Choy KW, Wang CC, Ogura A, Lau TK, Rogers MS, Ikeo K, Gojobori T, Lam DSC, Pang CCP

Physiol Genomics 2006;25(1): 9 - 15

110

Risk factors for procedure-related fetal losses after mid-trimester genetic amniocentesis.

Kong CW, Leung TN, Leung TY, Chan LW, Sahota DS, Fung TY, Lau TK

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111

A simple and rapid approach for screening of SARS-coronavirus genotypes: an evaluation study.

Chung GTY, Chiu Rossa WK, Cheung JLK, Jin Yongjie, Chim SSC, Chan PKS, Lo DYM

BMC Infect Dis 2005;5: 87

112

Detection of the placental epigenetic signature of the maspin gene in maternal plasma.

Chim SSC, Tong YK, Chiu Rossa WK, Lau TK, Leung TN, Chan LYS, Oudejans CBM, Ding CM, Lo DYM

Proc Natl Acad Sci USA 2005;102(41): 14753 - 14758

113

Detection of the placental epigenetic signature of the maspin gene in maternal plasma.

Chim SSC, Tong YK, Chiu RWK, Lau TK, Leung TN, Chan LYS, Oudejans CB, Ding C, Lo YMD.

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114

Expectation and knowledge of women undergoing first-trimester combined screening for Down syndrome in a Chinese population.

Chan LW, Chau MMC, Leung TY, Fung TY, Leung TN, Lau TK

Prenatal Diag 2005;25(13): 1248 - 1252

115

Genetic screening and diagnosis.

Lau TK, Leung TN

Curr Opin Obstet Gyn 2005;17(2): 163 - 169

116

Higher median levels of free beta-hCG and PAPP-A in the first trimester of pregnancy in a Chinese ethnic group. Implication for first trimester combined screening for Down's syndrome in the Chinese population.

Leung TY, Spencer K, Leung TN, Fung TY, Lau TK

Fetal Diagn Ther 2005;21(1): 140 - 143

117

Outcome of 1355 consecutive transabdominal chorionic villus samplings in 1351 patients.

Lau TK, Leung TY, Fung TY, Chan LW, Sahota DS, Leung TN

Chin Med J 2005;118(20): 1675 - 1681

118

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Leung TN, Lau TK, Chung TKH

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119

Application of expression genomics in drug development and genomic medicine.

Chin KV, Selvanayagam ZE, Vittal R, Kita T, Kudoh K, Yang CS, Wong YF, Cheung TH, Yeo W, Chung TKH, Lin Y, Liao J, Shih JW, Yap SF, Lin AW

Drug Develop Res 2004;62(2): 124 - 133

120

Molecular hierarchy in neurons differentiated from mouse ES cells containing a single human chromosome 21.

Wang CC, Kadota M, Nishigaki R, Kazuki Y, Shirayoshi Y, Rogers MS, Gojobori T, Ikeo K, Oshimura M

Biochem Bioph Res Co 2004;314(2): 335 - 350

121

MS analysis of single-nucleotide differences in circulating nucleic acids: Application to noninvasive prenatal diagnosis.

Ding CM, Chiu Rossa WK, Lau TK, Leung TN, Chan LC, Chan Amy YY, Charoenkwan P, Ng ISL, Law HY, Ma ESK, Xu X, Wanapirak C, Sanguansermsri T, Liao C, Tan Jin Ai MA, Chui DHK, Cantor CR, Lo DYM

Proc Natl Acad Sci USA 2004;101(29): 10762 - 10767

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Proteomic signatures and aberrations of mouse embryonic stem cells containing a single human chromosome 21 in neuronal differentiation: An in vitro model of down syndrome.

Kadota M, Nishigaki R, Wang CC, Toda T, Shirayoshi Y, Inoue T, Gojobori T, Ikeo K, Rogers MS, Oshimura M

Neuroscience 2004;129(2): 325 - 335

123

Systematic micro-array based identification of placental mRNA in maternal plasma: towards non-invasive prenatal gene expression profiling

Tsui NBY, Chim SSC, Chiu RWK, Lau TK, Ng EKO, Leung TN, Tong YK, Chan KCA, Lo YMD.

J Med Genet 2004;41:461-7. [Cited 80 times]

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Systematic micro-array based identification of placental mRNA in maternal plasma: towards non-invasive prenatal gene expression profiling.

Tsui NBY, Chim SSC, Chiu Rossa WK, Lau TK, Ng EKO, Leung TN, Tong YK, Chan AKC, Lo DYM

J Med Genet 2004;41(6): 461 - 467

125

Genetic alterations on chromosome 19, 20, 21, 22, and X detected by loss of heterozygosity analysis in retinoblastoma.

Huang Q, Choy KW, Cheung KF, Lam DSC, Fu WL, Pang CCP

Mol Vis 2003;9: 502 - 507

126

Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong.

Chim SSC, Tsui SKW, Chan KCA, Au TC, Hung EC, Tong YK, Chiu RWK, Ng EKO, Chan PK, Chu CM, Sung JJ, Tam JS, Fung KP, Waye MM, Lee CY, Yuen KY and Lo YMD.

Lancet 2003.362:1807-8. [Cited 37 times

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Human chorionic gonadotropin and 17-] estradiol regulation of human oviductin/oviduct specific glycoprotein mRNA expression in vitro.

Briton Jones C , Lok IH, Chiu TTY, Cheung LP, Haines CJ

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128

Management of infertility.

Lok IH, Cheung LP, Haines CJ

HK Pract 2003;25(6): 249 - 261

129

mRNA of placental origin is readily detectable in maternal plasma.

Ng EKO, Tsui NBY, Lau TK, Leung TN, Chiu Rossa WK, Panesar NS, Lit LCW, Chan KW, Lo DYM

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130

Loss of Heterozygosity at the short arm of chromosome 3 in microdissected cervical intraepithelial neoplasia.

Chung TKH, Cheung TH, Lo KWK, Yu MMY, Hampton GM, Wong HKT, Wong YF

Cancer Lett 2000;154(2): 189 - 194

131

Outcome of 555 Consecutive Transabdominal Chorionic Villus Samplings in a Teaching Hospital.

Lau TK, Chau MCM, Leung TY, Pang MW, Fung TY, Leung TN

HKJGOM 2000;1(1): 21 - 27

132

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Poon LLM, Leung TN, Lau TK, Lo DYM

Lancet 2000;356(924): 1819 - 1820

133

Maternal serum screening for Down syndrome in a teaching hospital in Hong Kong.(Chinese Article)

Law LK, Lau TK, Fung TY, Rogers MS, Hjelm NM

Chin Med J 1999;112(8): 754 - 757

134

Quantitative analysis of fetal DNA in maternal plasma and serum: implications for noninvasive prenatal diagnosis.

Lo DYM, Tein MSC, Lau TK, Haines CJ, Leung TN, Poon PMK, Wainscoat JS, Johnson PJ, Chang AMZ, Hjelm NM

Am J Hum Genet 1998;62: 768 - 775

135

Racial variation in incidence of Trisomy 21: A survey of 57,742 Chinese deliveries.

Lau TK, Fung HYM, Rogers MS, Cheung KL

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136

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Fung HYM, Wong YF, Haines CJ, Wong FWS

Acta Obstet Gyn Scan 1995;74(4): 248 - 250

1

Screening for spontaneous preterm birth by cervical length and shear-wave elastography in the first trimester of pregnancy

Feng Q, Chaemsaithong P, Duan H, Ju X, Appiah K, Shen L, Wang X, Tai Y, Leung TY, Poon LC

Am J Obstet Gynecol. 2022 Sep;227(3):500.e1-500.e14

2

Prediction of spontaneous preterm birth by cervical length in the first trimester of pregnancy: comparison of two measurement methods

Feng Q, Duan H, Ju X, Appiah K, Yip KM, Tai Y, Sun Q, Chaemsaithong P, Poon LC

Acta Obstet Gynecol Scand. 2021 Jul;100(7):1305-1312

3

(2021) Whole-transcriptome analysis of maternal blood for identification of RNA markers for predicting spontaneous preterm birth among preterm labour women: abridged secondary publication.

Chim SSC, Chan TF, Leung TY.

Hong Kong Med J 26 Suppl 6:20-23.

4

Impact of Maternal Gestational diabetes on neonatal outcome of late preterm infants

Fung GPG, Lao TTH

Clin Pediatr.2020 Nov 05; 3(1):1023

5

Cervical shear wave elastography as a predictor of preterm delivery during 18-24 weeks of pregnancy

Suthasmalee S, Moungmaithong S

Obstet. Gynaecol. Res. 2019; 45(11):2158-68

6

Prevention of Spontaneous Preterm Birth

Appiah K, Chaemsaithong P, Poon LC

MIMS JPOG 2019 ; 45 (4); 169-176

7

ASPRE trial: performance of screening for preterm pre-eclampsia

Rolnik DL, Wright D, Poon LC, Syngelaki A, O'Gorman N, de Paco Matallana C, Akolekar R, Cicero S, Janga D, Singh M, Molina FS, Persico N, Jani JC, Plasencia W, Papaioannou G, Tenenbaum-Gavish K, Nicolaides KH

Ultrasound Obstet Gynecol 2017 Oct;50(4):492-495

8

Aspirin for Evidence-Based Preeclampsia Prevention trial: effect of aspirin in prevention of preterm preeclampsia in subgroups of women according to their characteristics and medical and obstetrical history

Poon LC, Wright D, Rolnik DL, Syngelaki A, Delgado JL, Tsokaki T, Leipold G, Akolekar R, Shearing S, De Stefani L, Jani JC, Plasencia W, Evangelinakis N, Gonzalez-Vanegas O, Persico N, Nicolaides KH

Am J Obstet Gynecol. 2017 Nov;217(5):585.e1-585.e5

9

Aspirin for Evidence-Based Preeclampsia Prevention trial: influence of compliance on beneficial effect of aspirin in prevention of preterm preeclampsia

Wright D, Poon LC, Rolnik DL, Syngelaki A, Delgado JL, Vojtassakova D, de Alvarado M, Kapeti E, Rehal A, Pazos A, Carbone IF, Dutemeyer V, Plasencia W, Papantoniou N, Nicolaides KH

Am J Obstet Gynecol. 2017 Dec;217(6):685.e1-685.e5

10

Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia

Rolnik DL, Wright D, Poon LC, O'Gorman N, Syngelaki A, de Paco Matallana C, Akolekar R, Cicero S, Janga D, Singh M, Molina FS, Persico N, Jani JC, Plasencia W, Papaioannou G, Tenenbaum-Gavish K, Meiri H, Gizurarson S, Maclagan K, Nicolaides KH

N Engl J Med. 2017 Aug 17;377(7):613-622

11

Does Gestational Diabetes Mellitus Affect Respiratory Outcome in Late-Preterm Infants?

Fung GPG, Chan MLM, Ho Y, To WWK, Chan BHB, Lao TTH

Early Hum Dev 2014;90(9): 527 - 530

12

Cerclage Pessary for Preventing Preterm Birth in Women with a Singleton Pregnancy and a Short Cervix at 20 to 24 Weeks: A Randomized Controlled Trial.

Hui ASY, Chor MCM, Lau TK, Lao TTH, Leung TY

AM J Perinatol 2013;30(4): 283 - 288

13

C-reactive protein at 11 to 13 weeks™ gestation in spontaneous early preterm delivery.

Bakalis S, Poon LC, Vayna AM, Pafilis I, Nicolaides KH.

J Matern Fetal Neonatal Med 2012; 25: 2475-2478.

14

Systematic Identification of Spontaneous Preterm Birth-Associated RNA Transcripts in Maternal Plasma.

Chim SSC, Lee WS, Ting YH, Chan OK, Lee SWY, Leung TY

PLos ONE 2012;7(4): e34328

15

Genistein Upregulates Placental Corticotropin-Releasing Hormone Expression in Lipopolysaccharide-Sensitized Mice.

Huang H, Li L, Wang Y, Tang LY, Wang CC, Leung LK

Placenta 2011;32(10): 757 - 762

16

Preterm Birth Rates in Chinese Women in China, Hong Kong and Australia - The Price of Westernisation.

Newnham JP, Sahota DS, Zhang CY, Xu BY, Zheng MM, Doherty DA, Li SF, Chung TKH, Hu YL

Aust NZ J Obstet Gyn 2011;10(5): 426 - 431

17

Maternal height and length of gestation: does this impact on preterm labour in Asian women?

Chan BCP, Lao TTH

Aust NZ J Obstet Gyn 2009;49(4): 388 - 392

18

Supplementary oxygen for emergency Caesarean section under regional anaesthesia.

Khaw KS, Wang CC, Ngan Kee WD, Tam WH, Ng F, Critchley LAH, Rogers MS

Brit J Anaesth 2009;102(1): 90 - 96

19

Urgent Cesarean Delivery for Fetal Bradycardia.

Leung TY, Chung JPW, Rogers MS, Sahota DS, Lao TTH, Chung TKH

Obstet Gynecol 2009;114(5): 1023 - 1028

20

Fetal Medicine Foundation Prolonged Pregnancy Group. Cervical length and maternal factors in expectantly managed prolonged pregnancy: prediction of onset of labor and mode of delivery.

Rao A, Celik E, Poggi S, Poon L, Nicolaides KH;

Ultrasound Obstet Gynecol 2008; 32: 646-651.

21

Fetal nasal bone status in Chinese women undergoing first-trimester screening for trisomy 21.

Leung TY, Sahota DS, Chan LW, Law LW, Fung TY, Lau TK

Am J Obstet Gynecol 2008;199(5): 521.e1 - 521.e5

22

Maternal serum placental growth factor (plgf) at 11+0 to 13+6 weeks of gestation in small for gestational age pregnancy.

Poon LC, Zaragoza E, Akolekar R, Anagnostopoulos E, Nicolaides KH.

Prenatal Diagnosis 2008; 28: 1110-1115.

23

Mean arterial pressure at 11+0-13+6 weeks in the prediction of pre-eclampsia.

Poon LC, Kametas N, Pandeva IV, Valencia CM, Nicolaides KH.

Hypertension 2008; 51: 1027-1033.

24

Repeat Antenatal Corticosteroids: Should it be Prescribed and if so when and how?

Leung TY, Sahota DS

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25

Side-Effect and Vital Sign Profile of Nifedipine as a Tocolytic for Preterm Labour.

Chan LW, Sahota DS, Yeung SY, Leung TY, Fung TY, Lau TK, Leung TN

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Audit of the effectiveness of cervical preparation with Dilapan prior to late second trimester (20-24 weeks) surgical termination of pregnancy.

Poon LC, Parsons J.

BJOG 2007; 114: 485-488.

27

Cervical length at 18 - 22 weeks of gestation for prediction of spontaneous preterm delivery in Hong Kong Chinese women.

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28

The randomized nitric oxide tocolysis trial (RNOTT) for the treatment of preterm labor.

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Repeated courses of antenatal corticosteroids: Is it justified?

Leung TN, Lam PM, Ng PC, Lau TK

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Rare major maternal complications after second trimester amniocentesis: sequelae of avoiding a transplacental approach.

Lau TK, Leung TN, Leung TY, Pang MW, Tam WH

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Maternal plasma fetal DNA as a marker for preterm labour.

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1

Sonographic ‘barber-pole’ sign in fetal jejunoileal obstruction is suggestive of apple-peel atresia

Lu J, Law KM, Lyu GR, Chen BH, Yang GZ, Chen QH, Leung TY

Ultrasound Obstet Gynecol. 2022 Oct;60(4):580-581

2

Non-visualization of fetal gallbladder in a Chinese cohort

Ting YH, So PL, Cheung KW, Lo TK, Ma WLT, Leung TY

Hong Kong Med J. 2022 Apr;28(2):116-123

3

Clinical Opinion: The diagnosis and management of suspected fetal growth restriction: an evidence-based approach

Lees CC, Romero R, Stampalija T, Dall'Asta A, DeVore GA, Prefumo F, Frusca T, Visser GHA, Hobbins JC, Baschat AA, Bilardo CM, Galan HL, Campbell S, Maulik D, Figueras F, Lee W, Unterscheider J, Valensise H, Da Silva Costa F, Salomon LJ, Poon LC, Ferrazzi E, Mari G, Rizzo G, Kingdom JC, Kiserud T, Hecher K

Am J Obstet Gynecol. 2022 Mar;226(3):366-378

4

FIGO (international Federation of Gynecology and obstetrics) initiative on fetal growth: best practice advice for screening, diagnosis, and management of fetal growth restriction

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Int J Gynaecol Obstet. 2021 Mar;152 Suppl 1:3-57

5

Whole genome miRNA profiling revealed miR199a as potential placental pathogenesis of selective fetal growth restriction in monochorionic twin pregnancies

Meng M, Cheng YKK, Wu L, Chaemsaithong P, Leung MBW, Chim SSC, Sahota DS, Li W, Poon LCY, Wang CC, Leung TY

Placenta Volume 92, Mar 2020, Pages 44-53

6

ISUOG Practice Guidelines: diagnosis and management of small-for-gestational-age fetus and fetal growth restriction

Lees CC, Stampalija T, Baschat A, da Silva Costa F, Ferrazzi E, Figueras F, Hecher K, Kingdom J, Poon LC, Salomon LJ, Unterscheider J

Ultrasound Obstet Gynecol. 2020 Aug;56(2):298-312

7

Monochorionic twins with selective fetal growth restriction: insight from placental whole-transcriptome analysis

LI W, Chung CYL, Wang CC, Chan TF, Leung MBW, Chan OK, Wu L, APPIAH K, Chaemsaithong P, Cheng YKY, Poon LCY, Leung TY

Am J Obstet Gynecol. 2020 Nov;223(5):749.e1-749.e16

M

2.44

Rank%

6.502

8

Placental microRNA dataset of monochorionic twin pregnancies with and without selective fetal growth restriction

Meng M, Cheng YKK, Wu L, Chaemsaithong P, Leung MBW, Chim SSC, Sahota DS, Li W, Poon LCY, Wang CC, Leung TY

Data in Brief , Volume 30, Jun 2020, 105403, 5 pages

M

NA

Rank%

NA

9

(2020) Whole genome miRNA profiling revealed miR-199a as potential placental pathogenesis of selective fetal growth restriction in monochorionic twin pregnancies.

Meng M, Cheng YKY, Wu L, Chaemsaithong P, Leung MBW, Chim SSC, Sahota DS, Li W, Poon LCY, Wang CC, Leung TY.

Placenta 92:44-53.

10

Maternal hemodynamics, fetal biometry and Doppler indices in pregnancies followed up for suspected fetal growth restriction

Roberts LA, Ling HZ, Poon LC, Nicolaides KH, Kametas NA

Ultrasound Obstet Gynecol. 2018 Oct;52(4):507-514

11

Severe growth restriction undelivered at term and ultrasound examination: Some clarifications

Chung JPW, Li TC

Aust Nz J Obstet Gyn. Oct 2018; 58(5):E14, 1 page

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胎兒生長受限的診斷和處理.

Chen M, Hu ZY, Lau TK

Chinese Journals of Practical Medicine 2011;27(4): 105 - 108

13

Which Ultrasound or Biochemical Markers are Independent Predictors of Small-for-Gestational Age?

Law LW, Leung TY, Sahota DS, Chan LW, Fung TY, Lau TK

Ultrasound Obst Gyn 2009;34(3): 283 - 287

14

First-trimester fetal nasal bone length in an ethnic Chinese population.

Sahota DS, Leung TY, Chan LW, Law LW, Fung TY, Chan OK, Lau TK

Ultrasound Obst Gyn 2009;34(1): 33 - 37

15

Customized birth weight: coefficients and validation of models in a UK population.

Sahota DS, Kagan KO, Lau TK, Leung TY, Nicolaides KH

Ultrasound Obst Gyn 2008;32(7): 884 - 889

16

Fetal Biometry in Ethnic Chinese: Biparietal Diameter, Head Circumference, Abdominal Circumference and Femur Length.

Leung TN, Pang MW, Sahota DS, Leung TY, Poon CF, Wong SM, Lau TK

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17

Prediction of birth weight by fetal crown-rump length and maternal serum levels of pregnancy-associated plasma protein-A in the first trimester.

Leung TY, Sahota DS, Chan LW, Law LW, Fung TY, Leung TN, Lau TK

Ultrasound Obst Gyn 2008;31(1): 10 - 14

18

First-trimester maternal serum level of pregnancy-associated plasma protein-A is an independent predictor of fetal maxillary bone length.

Leung TY, Chan LW, Leung TN, Fung TY, Sahota DS, Lau TK

Ultrasound Obst Gyn 2006;27(1): 9 - 12

19

Impact of hypertensive disorders of pregnancy at term on infant birth weight.

Lau TK, Pang MW, Sahota DS, Leung TN

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20

Quantification of contact surface pressure exerted during external cephalic version.

Leung TY, Sahota DS, Fok AWY, Chan LW, Lau TK

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Relationship between umbilical cord morphology and nuchal cord entanglement.

Rogers MS, Ip Wan Yim, Qin Y, Rogers SM, Sahota DS

Acta Obstet Gyn Scan 2003;82(1): 32 - 37

22

Diclofenac-induced embryotoxicity is associated with increased embryonic 8-isoprostaglandin F2a level in rat whole embryo culture.

Chan Louis YS, Chiu PY, Siu NSS, Wang CC, Lau TK

Reprod Toxicol 2002;16(6): 841 - 844

23

Effect of twin-to-twin delivery interval on umbilical cord blood gas in the second twins.

Leung TY, Tam WH, Leung TN, Lok IH, Lau TK

BJOG 2002;109(1): 63 - 67

24

Oxidative stress in the fetal lamb brain following intermittent umbilical cord occlusion: a path analysis.

Rogers MS, Murray HGS, Wang CC, Pennell CE, Turner A, Ping Y, Pang CCP, Chang AMZ

BJOG 2001;108(12): 1283 - 1290

25

Response to letter to the editor by goldwurm and biondi - "Case of congenital hypotransferrinemia suggests that tissue hypoxia during fetal development may cause hypospadias.

Fung TY

Am J Med Genet 2000;95(3): 288

26

Intra-uterine growth retardation and transverse lie due to massive subchorionic thrombohematoma and overlying subchorionic cyst.

Tam WH, Fung HYM, Fung TY, Lau TK, To KF

Acta Obstet Gyn Scan 1997;76(4): 381 - 383

27

Is obstetric and neonatal outcome worse in fetuses who fail to reach their own growth potential?

Sanderson DA, Wilcox MA, Johnson IR

BJOG 1996;101: 87

1

The Use of Somatex Shunt for Fetal Pleural Effusion: A Cohort of 8 Procedures

Chung MY, Leung WC, Tse WT, Ting YH, Law KM, Hui ASY, Wah YMI, Lam HS, Poon LCY, Leung TY

Fetal Diagn Ther. 2021;48(6):440-447

2

Establishing Prenatal Surgery for Myelomeningocele in Asia: The Singapore Consensus

Wataganara T, Seshadri S, Leung TY, Matter C, Ngerncham M, Triyasunant N, Mali PV, Biswas A, Nawapun K, Phithakwatchara N, Flake AW, Johnson MP, Biswas A, Choolani M.

Fetal Diagn Ther. 2017 Apr;41(3):161-178

3

Ultrasound-Guided Percutaneous Embolisation of Placental Chorioangioma Using Cyanoacrylate

Cheng YKY, Yu SC, So PL, Leung TY

Fetal Diagn Ther. Feb 2017;41(1):76-79

4

Cardiomyogenesis of periodontal ligament-derived stem cells by dynamic tensile strain

Pelaez D, Acosta Torres Z, Ng TK, Choy KW, Pang CP, Cheung HS

Cell Tissue Res. 2017 Feb;367(2):229-241

5

Risk of preterm birth following treatment for cervical disease: Stakeholder meeting summary.

Sasieni P, Castanon A, Landy R, Kyrgiou M, Kitchener H, Quigley M, Poon LC, Shennan A, Paraskevaidis E, Hollingworth A, Soutter P, Freeman Wang T, Peebles D, Prendeville W, Patnick J.

British J Obstet Gynaecol 2015; doi: 10.1111/1471-0528.13839.

6

Rubella Seronegativity in Antenatal Screening - Is It Influenced by the Introduction of Universal Childhood Rubella Immunization?

Lao TTH, Sahota DS, Law LW, Leung TY

Vaccine 2015;33(38): 4776 - 4781

7

Radiofrequency Ablation for Selective Reduction in Complicated Monochorionic Multiple Pregnancies.

Lu J, Ting YH, Law KM, Lau TK, Leung TY

Fetal Diagn Ther 2013;34(4): 211 - 216

8

Intrapleural Injection of OK-432 as the Primary In-utero Treatment for Fetal Chylothorax.

Leung VKT, Suen SSH, Ting YH, Law LW, Lau TK, Leung TY

Hong Kong Med J 2012;18(2): 156 - 159

9

Successful Treatment of Severe Fetal Chylothorax Resistant to Repeated Pleuroamniotic Shunting by OK-432 Pleurodesis.

Lo TK, Lau WL, Lam YY, Tang MHY, Leung TY, Leung WC

Fetal Diagn Ther 2012;31(4): 260 - 263

10

Identification of Submicroscopic Chromosomal Aberrations in Fetuses with increased Nuchal Translucency and Apparently Normal Karyotype.

Leung TY, Vogel I, Lau TK, Chong WS, Hyett JA, Petersen OB, Choy KW

Ultrasound Obst Gyn 2011;38(3): 314 - 319

11

Fetoscopic Laser Photocoagulation in the Management of Twin-Twin Transfusion Syndrome: Local Experience from Hong Kong.

Yang X, Leung TY, Ngan Kee WD, Chen M, Chan LW, Lau TK

Hong Kong Med J 2010;16(4): 275 - 281

12

Fetal crown-rump length and estimation of gestational age in an ethnic Chinese population.

Sahota DS, Leung TY, Leung TN, Chan OK, Lau TK

Ultrasound Obst Gyn 2009;33(2): 157 - 160

13

First trimester measurements of nasal bone length using three-dimensional ultrasound.

Chen M, Wang HF, Leung TY, Fung TY, Chan LW, Sahota DS, Lao TTH, Lau TK

Prenatal Diag 2009;29(8): 766 - 770

14

Gastroschisis Associated with an Intra-abdominal Umbilical Vein Varix: A Report of 2 Cases.

Fung TY, Chan LW, Leung TY, Lau TK

Fetal Diagn Ther 2009;25(4): 404 - 406

15

Inflammatory cytokine tumor necrosis factor alpha confers precancerous phenotype in an organoid model of normal human ovarian surface epithelial cells.

Kwong J, Chan FL, Wong KK, Birrer MJ, Archibald KM, Balkwill FR, Berkowitz RS, Mok SC

Neoplasia 2009;11(6): 529 - 541

16

Real-time three-dimensional echocardiography using a matrix probe with live xPlane imaging of the interventricular septum.

Xiong Y, Wah YMI, Chen M, Leung TY, Lau TK

Ultrasound Obst Gyn 2009;34(5): 534 - 537

17

Sonographic features of anorectal atresia at 12 weeks.

Chen M, Meagher S, Simpson I, Lau TK

J Matern Fetal Neonatal Med 2009;22(10): 931 - 933

18

Ultrasound screening for fetal structural abnormalities performed by trained midwives in the second trimester in a low-risk population-an appraisal.

Chen M, Leung TY, Sahota DS, Fung TY, Chan LW, Law LW, Chau MMC, Lao TTH, Lau TK

Acta Obstet Gyn Scan 2009;88(6): 713 - 719

19

Volumetric (3D) imaging reduces inter- and intraobserver variation of fetal biometry measurements.

Chan LW, Fung TY, Leung TY, Sahota DS, Lau TK

Ultrasound Obst Gyn 2009;33(4): 447 - 452

20

First-trimester fetal nasal bone length in an ethnic Chinese population.

Sahota DS, Leung TY, Chan LW, Law LW, Fung TY, Chan OK, Lau TK

Ultrasound Obst Gyn 2009;34(1): 33 - 37

21

Comparison of Nuchal and Detailed Morphology Ultrasound Examinations in Early Pregnancy for Fetal Structural Abnormality Screening: A Randomized Controlled Trial.

Chen M, Lee CP, Lam YH, Tang RYK, Chan BCP, Wong SF, Tse LHY, Tang MHY

Ultrasound Obst Gyn 2008;31(2): 136 - 146

22

Customized birth weight: coefficients and validation of models in a UK population.

Sahota DS, Kagan KO, Lau TK, Leung TY, Nicolaides KH

Ultrasound Obst Gyn 2008;32(7): 884 - 889

23

Glucose intolerance and cardiometabolic risk in children exposed to maternal gestational diabetes mellitus in utero.

Tam WH, Ma RCW, Yang XL, Ko GTC, Tong PCY, Cockram CS, Sahota DS, Rogers MS, Chan JCN

Pediatrics 2008;122(6): 1229 - 1234

24

How true is a 'true' midsagittal section?

Wah YMI, Chan LW, Leung TY, Fung TY, Lau TK

Ultrasound Obst Gyn 2008;32(7): 855 - 859

25

Prenatal Screening for Retinoblastoma in Hong Kong.

Lau CSL, Choy KW, Fan DSP, Yu CBO, Wong CY, Lam DSC, Pang CCP

Hong Kong Med J 2008;14(5): 391 - 394

26

Fetal parvovirus B19 infection in a twin pregnancy with 1 twin presenting with hydrops fetalis and the other asymptomatic: a case report.

Leung TN, Leung TY, Chan PKS, Fung TY, Lau TK

J Reprod Med 2007;52(5): 419 - 421

27

Hypermethylation of RASSF1A in Human and Rhesus Placentas.

Chiu Rossa WK, Chim SSC, Wong IHN, Wong CSC, Lee CWS, To KF, Tong JHM, Yuen KC, Shum ASW, Chan JKC, Chan LYS, Yuen WF, Tong YK, Weier JF, Ferlatte C, Leung TN, Lau TK, Lo KW, Lo DYM

Am J Pathol 2007;170(3): 941 - 950

28

Tetralogy of Fallot in the fetus in the current era.

Poon LC, Huggon I, Zidere V and Allan LD.

Ultrasound Obstet Gynecol 2007; 29: 625-627.

29

Treatment of suspected fetal macrosomia: a cost-effectiveness analysis.

Sahota DS, Yuen PM, Rogers MS

Am J Obstet Gynecol 2007;196(3): e24 - e25

30

先天性膈疝的产前诊断及宫内治疗进展

乔宠, Lau TK, Jani J, Deprest J

Chin J Obstet Gynecol 2007;42(8): 563 - 566

31

双胎输血综合征的判断和临床处理

Wang HF, Lau TK

Chin J Prac Gynecol Obstet 2007;23(5): 347 - 351

32

Ex utero intrapartum treatment (EXIT) for congenital giant ranula.

Chan DFY, Lee CH, Fung TY, Chan LW, Abdullah V, Ng PC

Acta Paediatr 2006;95(10): 1303 - 1305

33

Fetal anaemia as a cause of fetal injury: diagnosis and management.

Wong YF, Cheung TH, Lo KWK, Yim SF, Chan LKY, Buhard O, Duval A, Chung TKH, Hamelin R

Carcinogenesis 2006;27(5): 951 - 955

34

Foetal magnetic resonance imaging.

Wong TYY, Lam WWM, Lau TK

Hong Kong Med J 2006;12(6): 486 - 487

35

Partial Neuroprotective Effect of Pretreatment with Tanshinone IIA on Neonatal Hypoxia-Ischemia Brain Damage.

Xia WJ, Yang M, Fok TF, Li KKH, Chan WY, Ng PC, Ng HK, Chik KW, Wang CC, Gu GJS, Woo KS, Fung KP

Pediatr Res 2005;58(4): 784 - 790

36

Prenatal embolisation of a large chorioangioma using enbucrilate.

Lau TK, Yu SCH, Leung TY, To KF, Fung TY, Leung TN

BJOG 2005;112(7): 1002 - 1004

37

Treatment of twin-twin transfusion syndrome by fetoscopic laser photocoagulation.

Lau TK, Leung TY, Fung TY, Leung TN

Chin Med J 2004;117(9): 1431 - 1434

38

A study of teratogenicity of hydrosalpinx fluid using a whole rat embryo culture model.

Chan Louis YS, Chiu PY, Cheung LP, Haines CJ, Tung HF, Lau TK

Hum Reprod 2003;18(5): 955 - 958

39

Accuracy of Clinical Diagnostic Methods of Threatened Abortion.

Yip SK, Sahota DS, Cheung LP, Lam PKW, Haines CJ, Chung TKH

Gynecol Obstet Inves 2003;56(1): 38 - 42

40

Prenatal Treatment of Chorioangioma by Microcoil Embolisation.

Lau TK, Leung TY, Yu SCH, To KF, Leung TN

BJOG 2003;110(1): 70 - 73

41

Fetal scalp cysts: challenge in diagnosis and counseling.

Lau TK, Leung TN, Leung TY, Pang MW, Tam WH

J Ultras Med 2001;20(2): 175 - 177

42

Multilevel modeling of fetal and placental growth using echo-planar magnetic resonance imaging.

Duncan KR, Sahota DS, Gowland PA, Moore R, Chang AMZ, Baker PN, Johnson IR

J Soc Gynecol Investig 2001;8(5): 285 - 290

43

In Utero Treatment of Hydrops Fetalis due to Parvovirus B19 Infection: a Case Report.

Ng PS, Leung TY, Leung TN, Lau TK

HKJGOM 2000;1(1): 67 - 70

44

Misoprostol's Effect on Uterine Arterial Blood Flow and Fetal Heart Rate in Early Pregnancy.

Yip SK, Tse AOK, Haines CJ, Chung TKH

Obstet Gynecol 2000;95(2): 232 - 235

45

In Utero Exchange Transfusion in Homozygous Alpha-Thalassaemia: A Case Report.

Fung TY, Lau TK, Tam WH, Li CK

Prenatal Diag 1998;18: 838 - 841

46

A review of laparoscopy and laparotomy in the management of tubal pregnancy.

Yuen PM, Rogers MS, Chang AMZ

Hong Kong Med J 1997;3(2): 153 - 157

47

Abdomino-amniotic shunting in isolated fetal ascites with polyhydramnios.

Fung TY, Fung HYM, Lau TK, Chang AMZ

Acta Obstet Gyn Scan 1997;76(7): 706 - 707

48

A randomized, double blind, controlled trial of tocolysis to assist external cephalic version in late pregnancy.

Chung TKH, Neale EJ, Lau TK, Rogers MS

Acta Obstet Gyn Scan 1996;75: 720 - 724

49

Improved intrapartum surveillance with PR interval analysis of the fetal electrocardiogram: a randomized trial showing a reduction in fetal blood sampling.

Wijngaarden WJVan, Sahota DS, James DK, Farrell T, Mires GJ, Wilcox MA, Chang AMZ

Am J Obstet Gynecol 1996;174: 1295 - 1299

50

Computerised fetal heart rate analysis in labour - effect of sampling rate.

Chang AMZ, Sahota DS, Reed NN, James DK, Mohajer MP

Eur J Obstet Gyn R B 1995;59(2): 125 - 129

51

Transient neonatal hyperthyrotropinaemia.

Lao TTH, Li CY, Panesar NS

Early Hum Dev 1992;28(1): 19 - 25

52

Improvement in umbilical doppler waveform following steroid administration.

Leung AKL, Neale EJ, Rogers MS

BJOG 1991;98(5): 492