Expansion of the clinical and molecular spectrum of WWOX-related epileptic encephalopathy

Chong SC, Cao Y, Fung ELW, Kleppe S, Gripp KW, Hertecant J, El-Hattab AW, Suleiman J, Clark G, von Allmen G, Rodziyevska O, Lewis RA, Rosenfeld JA, Dong J, Undiagnosed Diseases Network , Wang X, Miller MJ, Bi W, Liu P, Scaglia F

Am J Med Genet A 2023 Mar;191(3):776-785


Genetic screening in patients with ovarian dysfunction

Zeng Y, Li L, Li Q, Hu J, Zhang N, Wu L, Yan Z, Qu R, Dong J, Liu R, Choy KW, Wang L, Sang Q, Guan Y, Chen B

Clin Genet. 2023 Mar;103(3):352-357


Delayed interval delivery in twin pregnancy in Hong Kong: two case reports

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Hong Kong Med J 2023 Feb;29(1):73–5


Neonatal outcome of infants with umbilical cord arterial pH less than 7

Lau SL, Lok ZLZ, Hui SYA, Fung GPG, Lam HS, Leung TY

Acta Obstet Gynecol Scand 2023 Feb;102(2):174-180


TEDD: a database of temporal gene expression patterns during multiple developmental periods in human and model organisms

Zhou Z, Tan C, Chau MHK, Jiang X, Ke Z, Chen X, Cao Y, Kwok YK, Bellgard M, Leung TY, Choy KW, Dong Z

Nucleic Acids Res. 2023 Jan 6;51(D1):D1168-D1178


Early emergence of sexual dimorphism in ofspring leukocyte telomere length was associated with maternal and children’s glucose metabolism—a longitudinal study

Wong KK, Cheng FF, Lim CKP, Tam CHT, Tutino G, Lai YY, Wang CC, Hou Y, Chan MHM, Ho CS, Joglekar MV, Hardikar AA, Jenkins AJ, Metzger BE, Lowe WL, Tam WH, Ma RC

BMC Med. 2022 Dec 20;20(1):490


The Sperm Small RNA Transcriptome: Implications beyond Reproductive Disorder

Chan SY, Wan CWT, Law TYS, Chan DYL, Fok EKL

Int J Mol Sci. 2022 Dec 11;23(24):15716


Implementation of public funded genome sequencing in evaluation of fetal structural anomalies

So PL, Hui ASY, Ma TWL, Shu W, Hui APW, Kong CW, Lo TK, Kan ANC, Kan EYL, Chong SC, Chung BHY, Luk HM, Choy KW, Kan ASY, Leung WC

Genes (Basel). 2022 Nov 10;13(11):2088


Determining chorionicity and amnionicity in twin pregnancies: pitfalls

Lu J, Ting YH, Leung TY

Best Pract Res Clin Obstet Gynaecol. 2022 Nov;84:2-16


Genome-Wide Cell-Free DNA Test for Fetal Chromosomal Abnormalities and Variants: Unrestricted Versus Restricted Reporting

Kwan AHW, Zhu X, Mar Gil M, Kwok YKY, Wah IYM, Hui ASY, Ting YH, Law KM, Lau D, Xue S, Choy KW, Sahota D, Leung TY, Poon LC

Diagnostics (Basel). 2022 Oct 9;12(10):2439


Sonographic ‘barber-pole’ sign in fetal jejunoileal obstruction is suggestive of apple-peel atresia

Lu J, Law KM, Lyu GR, Chen BH, Yang GZ, Chen QH, Leung TY

Ultrasound Obstet Gynecol. 2022 Oct;60(4):580-581


Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes

Pervjakova N, Moen GH, Borges MC, Ferreira T, Cook JP, Allard C, Beaumont RN, Canouil M, Hatem G, Heiskala A, Joensuu A, Karhunen V, Kwak SH, Lin FTJ, Liu J, Rifas-Shiman S, Tam CH, Tam WH, Thorleifsson G, Andrew T, Auvinen J, Bhowmik B, Bonnefond A, Delahaye F, Demirkan A, Froguel P, Haller-Kikkatalo K, Hardardottir H, Hummel S, Hussain A, Kajantie E, Keikkala E, Khamis A, Lahti J, Lekva T, Mustaniemi S, Sommer C, Tagoma A, Tzala E, Uibo R, Vääräsmäki M, Villa PM, Birkeland KI, Bouchard L, Duijn CM, Finer S, Groop L, Hämäläinen E, Hayes GM, Hitman GA, Jang HC, Järvelin MR, Jenum AK, Laivuori H, Ma RC, Melander O, Oken E, Park KS, Perron P, Prasad RB, Qvigstad E, Sebert S, Stefansson K, Steinthorsdottir V, Tuomi T, Hivert MF, Franks PW, McCarthy MI, Lindgren CM, Freathy RM, Lawlor DA, Morris AP, Mägi R

Hum Mol Genet. 2022 Sep 29;31(19):3377-3391


Editorial: Chromosome structural variants: Epidemiology, identification and contribution to human diseases

Dong Z, David D, Gonzaga-Jauregui C, Morton CC, Zepeda-Mendoza CJ

Front Genet. 2022 Sep 9;13:1022918


Screening for spontaneous preterm birth by cervical length and shear-wave elastography in the first trimester of pregnancy

Feng Q, Chaemsaithong P, Duan H, Ju X, Appiah K, Shen L, Wang X, Tai Y, Leung TY, Poon LC

Am J Obstet Gynecol. 2022 Sep;227(3):500.e1-500.e14


Stillbirth rate in singleton pregnancies: a 20-year retrospective study from a public obstetric unit in Hong Kong

Wong STK, Tse WT, Lau SL, Sahota DS, Leung TY

Hong Kong Med J. 2022 Aug;28(4):285-293


Investigation of the genetic etiology in male infertility with apparently balanced chromosomal structural rearrangements by genome sequencing

Chau MHK, Li Y, Dai P, Shi M, Zhu X, Chung JPW, Kwok YK, Choy KW, Kong X, Dong Z

Asian J Androl. May-Jun 2022;24(3):248-254


Single Ce ll Proteomics Profiling Reveals That Embryo-Secreted TNF-alpha Plays a Critical Role During Embryo Implantation to the Endometrium

Lv J, Shan X, Yang H, Wen Y, Zhang X, Chen H, Li H, Tian D, Wang C C, Zhang R, Li TC, Zhang X, Zhao X, Lu Y, Qin L, Zhu M, Xu W XM, Lu Y, Qin L, Zhu MH, Xu WM

Reprod Sci. 2022 May;29(5):1608-1617


Single Cell Proteomics Profiling Reveals That Embryo-Secreted TNF-α Plays a Critical Role During Embryo Implantation to the Endometrium

Lv J, Shan X, Yang H, Wen Y, Zhang X, Chen H, Li H, Tian D, Wang CC, Zhang R, Li TC, Zhang X, Zhao X, Lu Y, Qin L, Zhu M, Xu W XM, Lu Y, Qin L, Zhu MH, Xu WM

Reprod Sci. 2022 May;29(5):1608-1617


The Burden and Benefits of Knowledge: Ethical Considerations Surrounding Population-Based Newborn Genome Screening for Hearing

Mitchell CO, Rivera-Cruz G, Chau MHK, Dong Z, Choy KW, Shen J, Amr S, Giersch ABS, Morton CC

Int J Neonatal Screen. 2022 May 27;8(2):36


Investigation of chromosomal structural abnormalities in patients with undiagnosed neurodevelopmental disorders

Cao Y, Luk HM, Zhang YY, Chau MHK, Xue S, Cheng SSW, Li AM, Chong JSC, Leung TY, Dong Z, Choy KW, Lo IFM

Front Genet. 2022 Apr 14;13:803088


Experience of Low-Pass Whole-Genome Sequencing-Based Copy Number Variant Analysis: A Survey of Chinese Tertiary Hospitals

Zheng Y, Zhu B, Tan J, Guan Y, The Chinese Genomic Structural Variants Consortium, Morton CC, Lu G

Diagnostics 2022 Apr, 12(5), 1098


Non-visualization of fetal gallbladder in a Chinese cohort

Ting YH, So PL, Cheung KW, Lo TK, Ma WLT, Leung TY

Hong Kong Med J. 2022 Apr;28(2):116-123


Whole Genome Transcriptomic Analysis of Ovary Granulosa Cells Revealed an Anti-Apoptosis Regulatory Gene DLGAP5 in Polycystic Ovary Syndrome

Deng Y, Li H, Song Y, Cen J, Zhang Y, Sui Y, Cui D, Li TC, Xu Y, Wang CC, Chung PWJ, Tang T

Front Endocrinol (Lausanne). 2022 Mar 18;13:781149


Clinical Opinion: The diagnosis and management of suspected fetal growth restriction: an evidence-based approach

Lees CC, Romero R, Stampalija T, Dall'Asta A, DeVore GA, Prefumo F, Frusca T, Visser GHA, Hobbins JC, Baschat AA, Bilardo CM, Galan HL, Campbell S, Maulik D, Figueras F, Lee W, Unterscheider J, Valensise H, Da Silva Costa F, Salomon LJ, Poon LC, Ferrazzi E, Mari G, Rizzo G, Kingdom JC, Kiserud T, Hecher K

Am J Obstet Gynecol. 2022 Mar;226(3):366-378


Prenatal Diagnosis of Ascending Aortic Aneurysm associated with Sternal Cleft (Letters to the Editor)

Lu J, Tse WT, Law KM, Leung TY

Ultrasound Obstet Gynecol. 2022 Feb;59(2):267-268


Whole-genome sequencing of genetically undiagnosed euploid fetuses with increased nuchal translucency: abridged secondary publication

Choy RKW, Cao Y, Lo FM, Cheung SW, Yang Y, Leung TY

Hong Kong Med J. 2022 Feb;28 Suppl 1(1):8-10


Contributions of common genetic variants to specific languages and to when a language is learned

Wong PCM, Kang X, So HC, Choy KW

Sci Rep. 2022 Jan 12;12(1):580


Associations of maternal weight status with the risk of offspring atopic dermatitis and wheezing by 1 year of age

Wei X, Huang P, Gao C, Shen S, Tu S, Guo Y, Zhang L, Lu MS, Lu J, Wang CC, He JR, Qiu X

Pediatr Allergy Immunol. 2022 Jan;33(1):e13703


Single-molecule sequencing reveals a large population of long cell-free DNA molecules in maternal plasma

Yu SCY, Jiang P, Peng W, Cheng SH, Cheung YTT, Tse OYO, Shang H, Poon LC, Leung TY, Chan KCA, Chiu RWK, Lo YMD

Proc Natl Acad Sci U S A. 2021 Dec 14;118(50):e2114937118


SVInterpreter: A Comprehensive Topologically Associated Domain-Based Clinical Outcome Prediction Tool for Balanced and Unbalanced Structural Variants

Fino J, Marques B, Dong Z, David D

Front Genet. 2021 Dec 1;12:757170


Chromosomal abnormalities and neurological outcomes in fetal cerebral ventriculomegaly: a retrospective cohort analysis

Lok WY, Kong CW, Hui SYA, Shi MM, Choy KW, To WK, Leung TY

Hong Kong Med J. 2021 Dec;27(6):428-436


Adaptive risk prediction system with incremental and transfer learning

Koivu A, Sairanen M, Airola A, Pahikkala T, Leung WC, Lo TK, Sahota DS

Comput Biol Med. 2021 Nov;138:104886


Intrauterine fetal death followed by shoulder dystocia and birth by modified posterior axillary sling method: a case report

Leung TY, Kwan AHW, Hui ASY, Lee JHS.

BMC Pregnancy Childbirth. 2021 Oct 3;21(1):672.  doi: 10.1186/s12884-021-04126-4.


Transperineal ultrasound assessment of fetal head elevation by maneuvers used for managing umbilical cord prolapse

Leung TY, Kwan AHW, Chaemsaithong P, Wong L, Tse WT, Hui ASY, Poon LC.

Ultrasound Obstet Gynecol. 2021 Oct;58(4):603-608. doi: 10.1002/uog.23544.


Umbilical cord prolapse: revisiting its definition and management

Wong L, Kwan AHW, Lau SL, Sin WTA, Leung TY

Am J Obstet Gynecol. 2021 Oct;225(4):357-366


Trio-Based Low-Pass Genome Sequencing Reveals Characteristics and Significance of Rare Copy Number Variants in Prenatal Diagnosis

Chau MHK, Qian J, Chen Z, Li Y, Zheng Y, Tse WT, Kwok YK, Leung TY, Dong Z, Choy KW

Front Genet. 2021 Sep 20;12:742325


A Fetus with Congenital Microcephaly, Microphthalmia and Cataract Was Detected with Biallelic Variants in the OCLN Gene: A Case Report

Ng VKS, Lau TK, Kan ASY, Chung BHY, Luk HM, Ng WF, Shi M, Choy KW, Cao Y, Leung WC

Diagnostics 2021 Aug;11(9): 1576


Outcome of radiofrequency ablation for selective fetal reduction before vs at or after 16 gestational weeks in complicated monochorionic pregnancy

Ting YH, Poon LCY, Tse WT, Chung MY, Wah YMI, Hui ASY, Law KM, Chaemsaithong P, Leung TY

Ultrasound Obstet Gynecol. 2021 Aug;58(2):214-220


Prediction of large-for-gestational age infants in relation to hyperglycemia in pregnancy - A comparison of statistical models

Gibbons KS, Chang AMZ, Ma RCW, Tam WH, Catalano PM, Sacks DA, Lowe J, McIntyre HD

Diabetes Res Clin Pract. 2021 Jul 22;178:108975


Low-pass genome sequencing-based detection of absence of heterozygosity: validation in clinical cytogenetics

Dong Z, Chau MHK, Zhang Y, Yang Z, Shi M, Wah YMI, Kwok YK, Leung TY, Morton C, Choy KW

Genet Med. 2021 Jul;23(7):1225-1233








Prediction of spontaneous preterm birth by cervical length in the first trimester of pregnancy: comparison of two measurement methods

Feng Q, Duan H, Ju X, Appiah K, Yip KM, Tai Y, Sun Q, Chaemsaithong P, Poon LC

Acta Obstet Gynecol Scand. 2021 Jul;100(7):1305-1312


Automated and precise recognition of human zygote cytoplasm: A robust image-segmentation system based on a convolutional neural network

Zhao M, Li H, Li R, Li Y, Luo X, Li TC, Lee TL, Wang WJ, Chan DYL

Biomedical Signal Processing and Control 2021 May;67:102551


Characteristics of Fetal Extrachromosomal Circular DNA in Maternal Plasma: Methylation Status and Clearance

Sin STK, Ji L, Deng J, Jiang P, Cheng SH, Heung MMS, Lau CSL, Leung TY, Chan KCA, Chiu RWK, Lo YMD

Clin Chem. 2021 Apr 29;67(5):788-796


The role of chromosomal microarray and exome sequencing in prenatal diagnosis

Chau MHK, Choy KW

Curr Opin Obstet Gynecol. 2021 Apr 1;33(2):148-155


Applications of genetic-epigenetic tissue mapping for plasma DNA in prenatal testing, transplantation and oncology

Gai W, Zhou Z, Agbor-Enoh S, Fan X, Lian S, Jiang P, Cheng SH, Wong J, Chan SL, Jang MK, Yang Y, Liang RH, Chan WK, Ma ES, Leung TY, Chiu RW, Valantine H, Chan KA, Lo YD

Elife. 2021 Mar 23;10:e64356


Clinical utility of expanded non-invasive prenatal screening and chromosomal microarray analysis in high-risk pregnancy

Zhu X, Chen M, Wang H, Guo Y, Chau MHK, Yan H, Cao Y, Kwok YKY, Chen J, Hui ASY, Zhang R, Meng Z, Zhu Y, Leung TY, Xiong L, Kong X, Choy KW

Ultrasound Obstet Gynecol. 2021 Mar;57(3):459-465


FIGO (international Federation of Gynecology and obstetrics) initiative on fetal growth: best practice advice for screening, diagnosis, and management of fetal growth restriction

Melamed N, Baschat A, Yinon Y, Athanasiadis A, Mecacci F, Figueras F, Berghella V, Nazareth A, Tahlak M, McIntyre HD, Costa FD, Kihara AB, Hadar E, McAuliffe F, Hanson M, Ma RC, Gooden R, Sheiner E, Kapur A, Divakar H, Ayres-de-Campos D, Hiersch L, Poon LC, Kingdom J, Romero R, Hod M

Int J Gynaecol Obstet. 2021 Mar;152 Suppl 1:3-57


First Case Report of Maternal Mosaic Tetrasomy 9p Incidentally Detected on Non-Invasive Prenatal Testing

Shu W, Cheng SSW, Xue S, Chan LW, Soong SI, Kan ASY, Cheung SWH, Choy KW

Genes 2021 Mar;12(3): 12030370


Performance of Cell-Free DNA Screening for Fetal Common Aneuploidies and Sex Chromosomal Abnormalities: A Prospective Study from a Less Developed Autonomous Region in Mainland China

Lai Y, Zhu X, He S, Dong Z, Tang Y, Xu F, Chen Y, Meng L, Tao Y, Yi S, Su J, Huang H, Luo J, Leung TY, Wei H

Genes 2021 Mar;12(4):12040478


Deciphering the complexity of simple chromosomal insertions by genome sequencing

Dong Z, Chau MHK, Zhang Y, Dai P, Zhu X, Leung TY, Kong X, Kwok YK, Stankiewicz P, Cheung SW, Choy KW

Hum Genet. 2021 Feb;140(2):361-380


The role of chromosomal microarray analysis among fetuses with normal karyotype and single system anomaly or nonspecific sonographic findings

Hui ASY, Chau MHK, Chan YM, Cao Y, Kwan AHW, Zhu X, Kwok YKY, Chen Z, Lao TTH, Choy KW, Leung TY

Acta Obstet Gynecol Scand. 2021 Feb;100(2):235-243


Bradycardia-to-delivery interval and fetal outcomes in umbilical cord prolapse

Wong L, Tse WT, Lai CY, Hui ASY, Chaemsaithong P, Sahota DS, Poon LC, Leung TY

Acta Obstet Gynecol Scand. 2021 Jan;100(1):170-177


(2021) Whole-transcriptome analysis of maternal blood for identification of RNA markers for predicting spontaneous preterm birth among preterm labour women: abridged secondary publication.

Chim SSC, Chan TF, Leung TY.

Hong Kong Med J 26 Suppl 6:20-23.


The Use of Somatex Shunt for Fetal Pleural Effusion: A Cohort of 8 Procedures

Chung MY, Leung WC, Tse WT, Ting YH, Law KM, Hui ASY, Wah YMI, Lam HS, Poon LCY, Leung TY

Fetal Diagn Ther. 2021;48(6):440-447


Whole genome miRNA profiling revealed miR199a as potential placental pathogenesis of selective fetal growth restriction in monochorionic twin pregnancies

Meng M, Cheng YKK, Wu L, Chaemsaithong P, Leung MBW, Chim SSC, Sahota DS, Li W, Poon LCY, Wang CC, Leung TY

Placenta Volume 92, Mar 2020, Pages 44-53


Detection and characterization of jagged ends of double-stranded DNA in plasma

Jiang P, Xie T, Ding SC, Zhou Z, Cheng SH, Chan RWY, Lee WS, Peng W, Wong J, Wong VWS, Chan HLY, Chan SL, Poon LCY, Leung TY, Chan KCA, Chiu RWK, Lo YMD

Genome Res. 2020 Aug;30(8):1144-1153


Early transient suppression of immune checkpoint proteins T-cell immunoglobulin mucin-3 and programmed cell death-1 in peripheral blood lymphocytes after blastocyst transfer is associated with successful implantation

Zhang T, Zhu W, Zhao Y, Cheung WC, Liu Y, Chen X, Du Y, Leung KT, Chan YL, Wang CC, Laird S, Li TC

Fertil Steril. 2020 Aug;114(2):426-435








ISUOG Practice Guidelines: diagnosis and management of small-for-gestational-age fetus and fetal growth restriction

Lees CC, Stampalija T, Baschat A, da Silva Costa F, Ferrazzi E, Figueras F, Hecher K, Kingdom J, Poon LC, Salomon LJ, Unterscheider J

Ultrasound Obstet Gynecol. 2020 Aug;56(2):298-312


Expected-value bias: is it time to remove features from ultrasound machines?

Sahota D

Ultrasound Obstet Gynecol. 2020 Mar;55(3):291-292


Clinical Significance of Non-Invasive Prenatal Screening for Trisomy 7: Cohort Study and Literature Review

Zhu X, Lam DYM, Chau MHK, Xue S, Dai P, Zhao G, Cao Y, Cheung SWH, Kwok YKY, Choy KW, Kong X, Leung TY

Genes (Basel). 2020 Dec 24;12(1):E11


Monochorionic twins with selective fetal growth restriction: insight from placental whole-transcriptome analysis

LI W, Chung CYL, Wang CC, Chan TF, Leung MBW, Chan OK, Wu L, APPIAH K, Chaemsaithong P, Cheng YKY, Poon LCY, Leung TY

Am J Obstet Gynecol. 2020 Nov;223(5):749.e1-749.e16








Impact of Maternal Gestational diabetes on neonatal outcome of late preterm infants

Fung GPG, Lao TTH

Clin Pediatr.2020 Nov 05; 3(1):1023


Noninvasive prenatal sequencing for multiple Mendelian monogenic disorders among fetuses with skeletal dysplasia or increased nuchal translucency

Yan H, Zhu X, Chen J, Cao Y, Kwok YKY, Chen Z, Leung TY, Chen M, Choy KW

Prenat Diagn. 2020 Oct;40(11):1459-1465


Development of the Birthweight Appropriateness Quotient: A New Measure of Infant's Size

Gibbons KS, McIntyre HD, Mamun A, Chang AMZ

Matern Child Health J. 2020 Oct;24(10):1202-1211


The utility of genome-wide cell-free DNA screening in the prenatal diagnosis of Pallister-Killian syndrome

Chau MHK, Lam YKD, Zhu X, Kwok YKY, Ting YH, Chan WP, Shi M, Cheung WH, Lau TK, Ville Y, Leung TY, Choy KW

Prenat Diagn. 2020 Jul;40(8):1005-1012








Placental microRNA dataset of monochorionic twin pregnancies with and without selective fetal growth restriction

Meng M, Cheng YKK, Wu L, Chaemsaithong P, Leung MBW, Chim SSC, Sahota DS, Li W, Poon LCY, Wang CC, Leung TY

Data in Brief , Volume 30, Jun 2020, 105403, 5 pages








Prevalence and heritability of handedness in a Hong Kong Chinese twin and singleton sample

Zheng M, McBride C, Ho CS, Chan JK, Choy KW, Paracchini S

BMC Psychol. 2020 Apr 22;8(1):37


Sequencing data of cell-free DNA fragments in living-related liver transplantation for inborn errors of metabolism

Zhu X, Ng HI, Xuan L, Long Y, Mao Y, Shi Y, Sun L, Liang B, Scaglia F, Zhu Z, Choy KW

Data Brief. 2020 Apr; 29: 105183, 6 pages








Low-pass genome sequencing versus chromosomal microarray analysis: implementation in prenatal diagnosis

Wang H, Dong Z, Zhang R, Chau MHK, Yang Z, Tsang K, Wong HK, Gui B, Meng Z, Xiao K, Zhu X, Wang Y, Chen S, Leung TY, Cheung SW, Kwok YK, Morton CC, Zhu Y, Choy KW

Genet Med, 2020 Mar;22(3):500-510


Recent Advances in the Noninvasive Prenatal Testing for Chromosomal Abnormalities Using Maternal Plasma DNA

Lau TK, Zhu X, Kwok YKY, Leung TY, Choy KW

Journal of Fetal Medicine, 2020 Mar;7(1):17-23


Bi-allelic Mutations in NADSYN1 Cause Multiple Organ Defects and Expand the Genotypic Spectrum of Congenital NAD Deficiency Disorders

Szot JO, Campagnolo C, Cao Y, Iyer KR, Cuny H, Drysdale T, Flores-Daboub JA, Bi W, Westerfield L, Liu P, Leung TN, Choy KW, Chapman G, Xiao R, Siu VM, Dunwoodie SL

Am J Hum Genet. 2020 Jan 2;106(1):129-136


(2020) Whole genome miRNA profiling revealed miR-199a as potential placental pathogenesis of selective fetal growth restriction in monochorionic twin pregnancies.

Meng M, Cheng YKY, Wu L, Chaemsaithong P, Leung MBW, Chim SSC, Sahota DS, Li W, Poon LCY, Wang CC, Leung TY.

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Additional benefits of three-dimensional ultrasound for prenatal assessment of twins

Wataganara T, Yapan P, Moungmaithong S, Sompagdee N, Phithakwatchara N, Limsiri P, Nawapun K, Rekhawasin T & Talungchit P

Journal of Perinatal Medicine, 48(2), 102-114


Increased Sylvian fissure angle as early sonographic sign of malformation of cortical development

Pooh RK, Machida M, Nakamura T, Uenishi K, Chiyo H, Itoh K, Yoshimatsu J, Ueda H, Ogo K, Chaemsaithong P, Poon LC

Ultrasound Obstet Gynecol. 2019 Aug;54(2):199-206


Transvaginal three-dimensional assessment of Sylvian fissures at 18-30 weeks’ gestation

Poon LC, Sahota DS, Chaemsaithong P, Nakamura T, Machida M, Naruse K, Wah YMI, Leung TY, Pooh RK

Ultrasound Obstet Gynecol. 2019 Aug;54(2):190-198


Do specific ultrasonography features identified at the time of early pregnancy loss predict fetal chromosomal abnormality? A systematic review and meta-analysis

Huang J, Zhu W, Tang J, Saravelos SH, Poon LC, Li TC

Genes Dis. 2019 Jun 6(2):129-137


Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin

Sun K, Jiang P, Cheng SH, Cheng THT, Wong J, Wong VWS, Ng SSM, Ma BBY, Leung TY, Chan SL, Mok TSK, Lai PBS, Chan HLY, Sun H, Chan KCA, Chiu RWK, Lo YMD

Genome Res. 2019 Mar;29(3):418-427


Prevalence of chromosomal abnormalities and 22q11.2 deletion in conotruncal and non-conotruncal antenatally diagnosed congenital heart diseases in a Chinese population

Kong CW, Cheng YKY, To WW, Leung TY

Hong Kong Med J. 2019 Feb;25(1):6-12


Clinical utility of noninvasive prenatal screening for pathogenic copy number variants REPLY

Chau MHK, Sahota DS, Choy KW

Am J Obstet Gynecol. 2019 Dec;221(6):661-662.


Prenatal visualization of paraumbilical veins in fetus with intra-abdominal umbilical vein stricture and intrauterine growth restriction

Chan YM, Law KM, Poon LC, Leung TY

Ultrasound Obstet Gynecol. 2019 Nov;54(5):697-698


Hypoechoic Liver in Fetuses with Trisomy 21

Omar PM, Lim WT, Ting YH, Lao TT, Law KM, Cheung AHK, Ng JKM, Leung TY

J Matern Fetal Neonatal Med. 2019 Oct;32(19):3315-3317


Enrichment of fetal and maternal long cell-free DNA fragments from maternal plasma following DNA repair

Vong JSL, Jiang P, Cheng SH, Lee WS, Tsang JCH, Leung TY, Chan KCA, Chiu RWK, Lo YMD

Prenat Diagn. 2019 Jan;39(2):88-99


Objective assessment of the fetal facial profile at second and third trimester of pregnancy

Lu J, Sahota DS, Poon LCY, Ting YH, Cheng YKY, Wang Y, Leung TY

Prenat Diagn. 2019 Jan;39(2):107-115


A Robust Polymerase Chain Reaction-based Assay for Quantifying Cytosine-guanine-guanine Trinucleotide Repeats in Fragile X Mental Retardation-1 Gene

Wang H, Zhu X, Gui B, Cheung WC, Shi M, Yang Z, Kwok YKY, Lim R, Pietilä S, Zhu Y, Choy KW

J Vis Exp. 2019 Sep 16;(151):e59963 (8 pages)


Prenatal Diagnosis of Fetuses with Increased Nuchal Translucency by Genome Sequencing Analysis

Choy KW, Wang H, Shi M, Chen J, Yang Z, Zhang R, Yan H, Wang Y, Chen S, Chau MHK, Cao Y, Chan OYM, Kwok YKY, Zhu Y, Chen M, Leung TY, Dong Z

Front Genet. 2019 Aug; volume 10:761 (14 pages)


Prenatal diagnosis of pathogenic genomic imbalance in fetuses with increased nuchal translucency but normal karyotyping using chromosomal microarray

Leung TY, Au Yeung KC, Leung WC, Leung KY, Lo TK, To WWK, Lau WL, Chan LW, Sahota DS, Choy KW

Hong Kong Med J. 2019 Aug;25 Suppl 5(4):30-32


Publisher Correction: Non-invasive prenatal sequencing for multiple Mendelian monogenic disorders using circulating cell-free fetal DNA

Zhang J, Li J, Saucier JB, Feng Y, Jiang Y, Sinson J, McCombs AK, Schmitt ES, Peacock S, Chen S, Dai H, Ge X, Wang G, Shaw CA, Mei H, Breman A, Xia F, Yang Y, Purgason A, Pourpak A, Chen Z, Wang X, Wang Y, Kulkarni S, Choy KW, Wapner RJ, Van den Veyver IB, Beaudet A, Parmar S, Wong LJ, Eng CM

Nat Med. 2019 Apr;25(4):701-702


Non-invasive prenatal sequencing for multiple Mendelian monogenic disorders using circulating cell-free fetal DNA

Zhang J, Li J, Saucier JB, Feng Y, Jiang Y, Sinson J, McCombs AK, Schmitt ES, Peacock S, Chen S, Dai H, Ge X, Wang G, Shaw CA, Mei H, Breman A, Xia F, Yang Y, Purgason A, Pourpak A, Chen Z, Wang X, Wang Y, Kulkarni S, Choy KW, Wapner RJ, Van den Veyver IB, Beaudet A, Parmar S, Wong LJ, Eng CM

Nat Med. 2019 Mar;25(3):439-447


Characteristics and mode of inheritance of pathogenic copy number variants in prenatal diagnosis

Chau MHK, Cao Y, Kwok YKY, Chan S, Chan YM, Wang H, Yang Z, Wong HK, Leung TY, Choy KW

American Journal of Obstetrics and Gynecology 2019;221(5):493e1-e11.


Cervical shear wave elastography as a predictor of preterm delivery during 18-24 weeks of pregnancy

Suthasmalee S, Moungmaithong S

Obstet. Gynaecol. Res. 2019; 45(11):2158-68


Clinical evaluation of a first trimester pregnancy algorithm predicting the risk of small for gestational age neonates

Graham K, Park F, McLennan A, Pelosi M, Williams P, Poon LC, Hyett J

Aust N Z J Obstet Gynaecol. 2019 Oct;59(5):670-676


Prevention of Spontaneous Preterm Birth

Appiah K, Chaemsaithong P, Poon LC

MIMS JPOG 2019 ; 45 (4); 169-176


Increasing influenza vaccine uptake in children: A randomized controlled trial

Yeung KHT, Tarrant M, Chan KCC, Tam WH, Nelson EAS

Vaccine. 2018 Sep 5;36(37):5524-5535


Prediction and prevention of small-for-gestational-age neonates: evidence from SPREE and ASPRE

Tan MY, Poon LC, Rolnik DL, Syngelaki A, de Paco Matallana C, Akolekar R, Cicero S, Janga D, Singh M, Molina FS, Persico N, Jani JC, Plasencia W, Greco E, Papaioannou G, Wright D, Nicolaides KH

Ultrasound Obstet Gynecol. 2018 Jul;52(1):52-59


Prospective assessment of INTERGROWTH-21st and World Health Organization estimated fetal weight reference curves

Cheng YKY, Lu J, Leung TY, Chan OYM, Sahota DS

Ultrasound Obstet Gynecol. 2018 Jun;51(6):792-798


Three decades of neonatal vaccination has greatly reduced antenatal prevalence of hepatitis B virus infection among gravidae covered by the program

Lao TT, Sahota DS, Chan PKS

J Infect. 2018 Jun;76(6):543-549


Vitamin D deficiency among healthy infants in Hong Kong: a pilot study

Chan KCC, Tam WH, Chan MHM, Chan RSM, Li AM

Hong Kong Med J. 2018 Jun;24 Suppl 3(3):32-35


Size-tagged preferred ends in maternal plasma DNA shed light on the production mechanism and show utility in noninvasive prenatal testing

Sun K, Jiang P, Wong AIC, Cheng YKY, Cheng SH, Zhang H, Chan KCA, Leung TY, Chiu RWK, Lo YMD

Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5106-E5114


Prevention of early onset group B streptococcal disease by universal antenatal culture-based screening in all public hospitals in Hong Kong

Ma TWL, Chan V, So CH, Hui ASY, Lee CN, Hui APW, So PL, Kong CW, Fung B, Leung KY ,Teresa W. L. Ma, Viola Chan, C. H. So, Hui ASY, C. N. Lee, Amelia P. W. Hui, P. L. So, C. W. Kong, Barbara Fung,

J Matern Fetal Neonatal Med. 2018 Apr;31(7):881-887


Noninvasive reconstruction of placental methylome from maternal plasma DNA: Potential for prenatal testing and monitoring

Sun K, Lun FMF, Leung TY, Chiu RWK, Lo YMD, Sun H

Prenat Diagn. 2018 Feb;38(3):196-203


Maternal hemodynamics, fetal biometry and Doppler indices in pregnancies followed up for suspected fetal growth restriction

Roberts LA, Ling HZ, Poon LC, Nicolaides KH, Kametas NA

Ultrasound Obstet Gynecol. 2018 Oct;52(4):507-514


Severe growth restriction undelivered at term and ultrasound examination: Some clarifications

Chung JPW, Li TC

Aust Nz J Obstet Gyn. Oct 2018; 58(5):E14, 1 page


Identification of balanced chromosomal rearrangements previously unknown among participants in the 1000 Genomes Project: implications for interpretation of structural variation in genomes and the future of clinical cytogenetics

Dong Z, Wang H, Chen H, Jiang H, Yuan J, Yang Z, Wang WJ, Xu F, Guo X, Cao Y, Zhu Z, Geng C, Cheung CWC, Kwok YKY, Yang H, Leung TY, Morton CC, Cheung SW, Choy KW

Genet Med. 2018 Jul;20(7):697-707


Target-enriched massively parallel sequencing for genetic diagnosis of hereditary hearing loss in patients with normal array CGH result

Choy KW, Cao Y, Lam STS, Lo FM, Morton CC, Leung TY

Hong Kong Med J. 2018 Jun;24 Suppl 3(3):11-14


Women’s preference for non-invasive prenatal DNA testing versus chromosomal microarray after screening for Down syndrome: a prospective study

Cheng YKY, Leung WC, Leung TY, Choy KW, Chiu RWK, Lo TK, Kwok YKY, Sahota DS

BJOG. 2018 Mar;125(4):451-459


Balanced Chromosomal Rearrangement Detection by Low-Pass Whole-Genome Sequencing

Dong Z, Ye L, Yang Z, Chen H, Yuan J, Wang H, Guo X, Li Y, Wang J, Chen F, Cheung SW, Morton CC, Jiang H, Choy KW

Curr Protoc Hum Genet. 2018 Jan 24;96:8.18.1-8.18


Molecular and clinical characterization of citrin deficiency in a cohort of Chinese patients in Hong Kong

Chong SC, Lo P, Chow CW, Yuen L, Chu WCW, Leung TY, Hui J, Scaglia F

Mol Genet Metab Rep. 2018 Sep 1;17:3-8


First Report of a Novel Deletion Due to εγδβ-Thalassemia in a Chinese Family

Hui ASY, Au PKC, Ting YH, Kan ASY, Cheng YKY, Leung AWK, Chan KYK, Li CK, Tang MHY, Leung TY

Hemoglobin. 2017 Sep;41(3):175-179


Obstetric professionals' perceptions of non-invasive prenatal testing for Down syndrome: clinical usefulness compared with existing tests and ethical implications

Ngan OMY, Yi H, Wong SYS, Sahota DS, Ahmed S

BMC Pregnancy Childbirth. 2017 Sep 5;17(1):285


Triplet pregnancy with fetal reduction: experience in Hong Kong

Tse WT, Law LW, Sahota DS, Leung TY, Cheng YK

Hong Kong Med J. 2017 Aug;23(4):326-32


Antenatal diagnosis and management of foetal intestinal volvulus

Yip KW, Cheng YKY, Leung TY

Med J Malaysia. 2017 Apr;72(2):126-127


Establishing Prenatal Surgery for Myelomeningocele in Asia: The Singapore Consensus

Wataganara T, Seshadri S, Leung TY, Matter C, Ngerncham M, Triyasunant N, Mali PV, Biswas A, Nawapun K, Phithakwatchara N, Flake AW, Johnson MP, Biswas A, Choolani M.

Fetal Diagn Ther. 2017 Apr;41(3):161-178


Perturbation of Retinoid Homeostasis Increases Malformation Risk in Embryos Exposed to Pregestational Diabetes

Lee LM, Leung MB, Kwok RC, Leung YC, Wang CC, McCaffery PJ, Copp AJ, Shum AS

Diabetes. 2017 Apr;66(4):1041-1051


Procedure-Related Fetal Loss following Chorionic Villus Sampling after First-Trimester Aneuploidy Screening

Wah YMI, Leung TY, Cheng YKY, Sahota DS

Fetal Diagn Ther. Apr 2017;41(3):184-190


Gestational Age Assessment by Methylation and Size Profiling of Maternal Plasma DNA: A Feasibility Study

Jiang P, Tong YK, Sun K, Cheng SH, Leung TY, Allen Chan KC, Chiu RW, Ming Dennis Lo Y

Clin Chem. 2017 Feb;63(2):606-608


Ultrasound-Guided Percutaneous Embolisation of Placental Chorioangioma Using Cyanoacrylate

Cheng YKY, Yu SC, So PL, Leung TY

Fetal Diagn Ther. Feb 2017;41(1):76-79


Universal Haplotype-Based Noninvasive Prenatal Testing for Single Gene Diseases

Hui WW, Jiang P, Tong YK, Lee WS, Cheng YKY, New MI, Kadir RA, Chan KC, Leung TY, Lo YM, Chiu RW

Clin Chem Feb 2017 ;63(2):513-524


ASPRE trial: performance of screening for preterm pre-eclampsia

Rolnik DL, Wright D, Poon LC, Syngelaki A, O'Gorman N, de Paco Matallana C, Akolekar R, Cicero S, Janga D, Singh M, Molina FS, Persico N, Jani JC, Plasencia W, Papaioannou G, Tenenbaum-Gavish K, Nicolaides KH

Ultrasound Obstet Gynecol 2017 Oct;50(4):492-495


Expanded newborn metabolic screening programme in Hong Kong: a three-year journey

Chong SC, Law LK, Hui J, Lai CY, Leung TY, Yuen YP

Hong Kong Med J. 2017 Oct;23(5):489-96


Validation of a high-throughput and robust technique: BACs-on-beads assay (KaryoLite BoBs) for pre-implantation aneuploidy screening

Kong GWS, Ma Y, Ou J, Kwok YKY, Wang W, Yeung QSY, Wong CKM, Li Q, Xu W, Lu W, Li H, Li TC, Choy KW

Taiwan J Obstet Gynecol. 2017 Aug;56(4):514-520


Chromosome copy number variants in fetuses with syndromic malformations

Wang H, Chau MHK, Cao Y, Kwok KY, Choy KW

Birth Defects Res. Jun 2017 ;109(10):725-733


Identification of fragile X pre-mutation carriers in the Chinese obstetric population using a robust FMR1 polymerase chain reaction assay: implications for screening and prenatal diagnosis

Cheng Y KY , Lin CSW, Kwok YKY, Chan OYM , Lau TK , Leung TY , Choy KW

Hong Kong Med J. 2017 Apr;23(2):110-6


Cardiomyogenesis of periodontal ligament-derived stem cells by dynamic tensile strain

Pelaez D, Acosta Torres Z, Ng TK, Choy KW, Pang CP, Cheung HS

Cell Tissue Res. 2017 Feb;367(2):229-241


Combined Count- and Size-Based Analysis of Maternal Plasma DNA for Noninvasive Prenatal Detection of Fetal Subchromosomal Aberrations Facilitates Elucidation of the Fetal and/or Maternal Origin of the Aberrations

Yu SC, Jiang P, Allen Chan KC, Faas BH, Choy KW, Leung WC, Leung TY, Dennis Lo YM, Chiu RW

Clin Chem. 2017 Feb;63(2):495-502


Aspirin for Evidence-Based Preeclampsia Prevention trial: effect of aspirin in prevention of preterm preeclampsia in subgroups of women according to their characteristics and medical and obstetrical history

Poon LC, Wright D, Rolnik DL, Syngelaki A, Delgado JL, Tsokaki T, Leipold G, Akolekar R, Shearing S, De Stefani L, Jani JC, Plasencia W, Evangelinakis N, Gonzalez-Vanegas O, Persico N, Nicolaides KH

Am J Obstet Gynecol. 2017 Nov;217(5):585.e1-585.e5


Aspirin for Evidence-Based Preeclampsia Prevention trial: influence of compliance on beneficial effect of aspirin in prevention of preterm preeclampsia

Wright D, Poon LC, Rolnik DL, Syngelaki A, Delgado JL, Vojtassakova D, de Alvarado M, Kapeti E, Rehal A, Pazos A, Carbone IF, Dutemeyer V, Plasencia W, Papantoniou N, Nicolaides KH

Am J Obstet Gynecol. 2017 Dec;217(6):685.e1-685.e5


Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia

Rolnik DL, Wright D, Poon LC, O'Gorman N, Syngelaki A, de Paco Matallana C, Akolekar R, Cicero S, Janga D, Singh M, Molina FS, Persico N, Jani JC, Plasencia W, Papaioannou G, Tenenbaum-Gavish K, Meiri H, Gizurarson S, Maclagan K, Nicolaides KH

N Engl J Med. 2017 Aug 17;377(7):613-622


Applicability of first-trimester combined screening for fetal trisomy 21 in a resource-limited setting in mainland China

Li B, Sahota DS, Lao TT, Xu J, Hu SQ, Zhang L, Liu QY, Sun Q, Tang D, Ma RM

BJOG: An International Journal of Obstetrics and Gynaecology Sep 2016 123( S3): 23-29


Impact of Replacing Chinese Ethnicity-specific Fetal Biometry Charts with the INTERGROWTH-21St Standard.

Cheng YKY, Leung TY, Lao TTH, Chan OYM, Sahota DS

BJOG Sep 2016;123(S3): 48 - 56


Pseudoamniotic Band Syndrome after In Utero Intervention for Twin-to-Twin Transfusion Syndrome: Case Reports and Literature Review.

Ting YH, Lao TTH, Law KM, Cheng YKY, Lau TK, Leung TY

Fetal Diagn Ther Jul 2016;40(1): 67 - 72


Immune Persistence after Hepatitis B Vaccination in Infancy - Fact or Fancy?


Hum Vacc Immunother May 2016;12(5): 1172 - 1176


Prenatal detection of 10q22q23 duplications: dilemmas in phenotype prediction

Kong GWS, Cao Y, Huang J, Cheng KY, Pursley AN, Rosenfeld JA, Edwards J G, Chan YM, Cheung SW, Leung TY, Choy KW

Prenat Diagn. 2016 Dec;36(13):1211-1216


Second Generation Noninvasive Fetal Genome Analysis Reveals De Novo Mutations, Single-Base Parental Inheritance, and Preferred DNA Ends

Chan KC, Jiang P, Sun K, Cheng YKY, Tong YK, Cheng SH, Wong AI, Hudecova I, Leung TY, Chiu RW, Lo YM

Proc Natl Acad Sci U S A Dec 2016;113(50):E8159-E8168


Birth weight in live births and stillbirths

Poon LC, Tan MY, Yerlikaya G, Syngelaki A, Nicolaides KH

Ultrasound Obstet Gynecol Nov 2016;48(5):602-606


Increased Bone Turnover, Osteoporosis, Progressive Tibial Bowing, Fractures, and Scoliosis in a Patient with a Final-Exon SATB2 Frameshift Mutation.

Boone PM, Chan OYM, Hunter JV, Pottkotter LE, Davino NA, Yang Y, Beuten J, Bacino CA

Am J Med Genet Part A Nov 2016;170(11): 3028 - 3032


Genome-wide associations for birth weight and correlations with adult disease

Horikoshi M, Beaumont RN, Day FR, Warrington NM, Kooijman MN, Fernandez-Tajes J, Feenstra B, van Zuydam NR, Gaulton KJ, Grarup N, Bradfield JP, Strachan DP, Li-Gao R, Ahluwalia TS, Kreiner E, Rueedi R, Lyytikäinen LP, Cousminer DL, Wu Y, Thiering E, Wang CA, Have CT, Hottenga JJ, Vilor-Tejedor N, Joshi PK, Boh ET, Ntalla I, Pitkänen N, Mahajan A, van Leeuwen EM, Joro R, Lagou V, Nodzenski M, Diver LA, Zondervan KT, Bustamante M, Marques-Vidal P, Mercader JM, Bennett AJ, Rahmioglu N, Nyholt DR, Ma RC, Tam CH, Tam WH; CHARGE Consortium Hematology Working Group, Ganesh SK, van Rooij FJ, Jones SE, Loh PR, Ruth KS, Tuke MA, Tyrrell J, Wood AR, Yaghootkar H, Scholtens DM, Paternoster L, Prokopenko I, Kovacs P, Atalay M, Willems SM, Panoutsopoulou K, Wang X, Carstensen L, Geller F, Schraut KE, Murcia M, van Beijsterveldt CE, Willemsen G, Appel EV, Fonvig CE, Trier C, Tiesler CM, Standl M, Kutalik Z, Bonàs-Guarch S, Hougaard DM, Sánchez F, Torrents D, Waage J, Hollegaard MV, de Haan HG, Rosendaal FR, Medina-Gomez C, Ring SM, Hemani G, McMahon G, Robertson NR, Groves CJ, Langenberg C, Luan J, Scott RA, Zhao JH, Mentch FD, MacKenzie SM, Reynolds RM; Early Growth Genetics (EGG) Consortium, Lowe WL, Tönjes A, Stumvoll M, Lindi V, Lakka TA, van Duijn CM, Kiess W, Körner A, Sørensen TI, Niinikoski H, Pahkala K, Raitakari OT, Zeggini E, Dedoussis GV, Teo YY, Saw SM, Melbye M, Campbell H, Wilson JF, Vrijheid M, de Geus EJ, Boomsma DI, Kadarmideen HN, Holm JC, Hansen T, Sebert S, Hattersley AT, Beilin LJ, Newnham JP, Pennell CE, Heinrich J, Adair LS, Borja JB, Mohlke KL, Eriksson JG, Widén E, Kähönen M, Viikari JS, Lehtimäki T, Vollenweider P, Bønnelykke K, Bisgaard H, Mook-Kanamori DO, Hofman A, Rivadeneira F, Uitterlinden AG, Pisinger C, Pedersen O, Power C, Hyppönen E, Wareham NJ, Hakonarson H, Davies E, Walker BR, Jaddoe VW, Järvelin MR, Grant SF, Vaag AA, Lawlor DA, Frayling TM, Smith GD, Morris AP, Ong KK, Felix JF, Timpson NJ, Perry JR, Evans DM, McCarthy MI, Freathy RM

Nature. 2016 Oct 13;538(7624):248-252


Low-pass Whole-genome Sequencing in Clinical Cytogenetics: A Validated Approach

Dong Z, Zhang J, Hu P, Chen H, Xu J, Tian Q, Meng L, Ye Y, Wang J, Zhang M, Li Y, Wang HL, Yu S, Chen F, Xie J, Jiang H, Wang W, Choy KW, Xu Z

Genet Med Sep 2016;18(9): 940 - 948


A γA-Crystallin Mouse Mutant Secc with Small Eye, Cataract and Closed Eyelid.

Cheng MH, Tam CN, Choy KW, Tsang WH, Tsang SL, Pang CCP, Song YQ, Sham MH

PLos ONE Aug 2016;11(8): e0160691 (1 - 15)


Validation of a Robust PCR-Based Assay for Quantifying Fragile X CGG Repeats.

Kwok YKY, Wong CKM, Lo FM, Kong GWS, Moore JK, Wu S, Lam STS, Schermer M, Leung TY, Choy KW

Clin Chim Acta Mar 2016;456(2016): 137 - 143


MiR-449a Affects Epithelial Proliferation during the Pseudoglandular and Canalicular Phases of Avian and Mammal Lung Development.

Sanford EL, Choy KW, Donahoe PK, Tracy AA, Hila R, Loscertales M, Longoni M

PLos ONE Feb 2016;11(2): 149425


Clinical implementation of routine screening for fetal trisomies by the cell-free DNA test contingent on results from first-trimester combined test.

Gil MM, Revello R, Poon LC, Akolekar R, Nicolaides KH.

Ultrasound Obstet Gynecol 2016; 47:45-52.


Clinical validation of the ION test for first-trimester detection of trisomy 21, 18 and 13.

Poon LC, Dumidrascu-Diris D, Francisco C, Fantasia I, Nicolaides KH.

Ultrasound Obstet Gynecol 2016; 47:184-187


Eczema Susceptibility and Composition of Faecal Microbiota at 4 Weeks of Age: A Pilot Study in Chinese Infants.

Tang MF, Sy HY, Kwok JSL, Tam WH, Hon EKL, Tung CKC, Wong GWK, Tsui SKW, Leung TF

Br J Dermatol Apr 2016;174(4): 898 - 900


SNaPshot Reveals High Mutation and Carrier Frequencies of 15 Common Hearing Loss Mutants in a Chinese Newborn Cohort.

Chen Y, Cao Ye, Li HB, Mao J, Liu MJ, Liu YH, Wang BJ, Jiang D, Zhu Q, Ding Y, Wang W, Li H, Choy KW

Clin Genet 2015;87(5): 467 - 472


Aflatoxin B1 Augments the Synthesis of Corticotropin Releasing Hormone in JEG-3 Placental Cells.

Wang YF, Tan WJ, Wang CC, Leung LK

Chem-Biol Interact 2015;237(2015): 73 - 79


Current controversies in prenatal diagnosis 3: Is there still a Value in a Nuchal Translucency Screening Ultrasound in conjunction with Maternal Plasma Non-Invasive cell free DNA testing

Wilson RD, Poon LC, and Ghidini A.

Prenatal Diagnosis 2015; doi: 10.1002/pd.4719. [Epub ahead of print_]


Hepatitis B Vaccine Response among Infants Born to Hepatitis B Surface Antigen-positive Women.

Lao TTH, Cheung KL, Wong VWS

Vaccine 2015;33(1): 15 - 16


Prediction of small for gestational age neonates: screening by fetal biometry at 19-24 weeks.

Lesmes C, Gallo D, Panaiotova J,ƒ Poonƒ LC*,ƒ Nicolaidesƒ KH.

Ultrasound Obstet Gynecol 2015; 46: 198-207.


Prediction of small for gestational age neonates: screening by fetal biometry at 30-34 weeks.

Bakalis S, Silva M, Akolekar R,ƒ Poonƒ LC*,ƒ Nicolaidesƒ KH.

Ultrasound Obstet Gynecol 2015; 45: 551-558.


Prediction of small for gestational age neonates: Screening by maternal serum biochemical markers at 19-24 weeks.

Lesmes C, Gallo DM, Gonzalez R,ƒ Poonƒ LC*,ƒ Nicolaidesƒ KH.

Ultrasound Obstet Gynecol. 2015 May 13. doi: 10.1002/uog.14899. [Epub ahead of print_]


Prediction of small for gestational age neonates: screening by uterine artery Doppler and mean arterial pressure at 19-24 weeks.

Lesmes C, Gallo DM, Saiid Y,ƒ Poonƒ LC*,ƒ Nicolaidesƒ KH.

Ultrasound Obstet Gynecol. 2015 Mar 24. doi: 10.1002/uog.14855. [Epub ahead of print_]


Prediction of small for gestational age neonates: Screening by uterine artery Doppler and mean arterial pressure at 30-34 weeks.

Bakalis S, Stoilov B, Akolekar R,ƒ Poonƒ LC*,ƒ Nicolaidesƒ KH.

Ultrasound Obstet Gynecol 2015; 45: 707-714.


Prediction of small-for-gestational-age neonates: maternal biochemical markers at 30-34 weeks.

Bakalis S, Gallo DM, Mendez O,ƒ Poonƒ LC*,ƒ Nicolaidesƒ KH.

Ultrasound Obstet Gynecol 2015; 46: 208-215.


Prediction of small-for-gestational-age neonates: screening by biophysical and biochemical markers at 30-34 weeks.

Bakalis S, Peeva G, Gonzalez R,ƒ Poonƒ LC*,ƒ Nicolaidesƒ KH.

Ultrasound Obstet Gynecol. 2015 Mar 31. doi: 10.1002/uog.14863. [Epub ahead of print_]


Prediction of small-for-gestational-age neonates: screening by fetal biometry at 35-37 weeks.

Fadigas C, Saiid Y, Gonzalez R,ƒ Poonƒ LC*,ƒ Nicolaidesƒ KH.

Ultrasound Obstet Gynecol 2015; 45: 559-565.


Prediction of small-for-gestational-age neonates: screening by placental growth factor and soluble fms-like tyrosine kinase-1 at 35-37 weeks.

Fadigas C, Peeva G, Mendez O,ƒ Poonƒ LC*,ƒ Nicolaidesƒ KH.

Ultrasound Obstet Gynecol 2015; 46: 191-197.


Prediction of small-for-gestational-age neonates: screening by uterine artery Doppler and mean arterial pressure at 35-37 weeks.

Fadigas C, Guerra L, Garcia-Tizon Larroca S,ƒ Poonƒ LC*,ƒ Nicolaidesƒ KH.

Ultrasound Obstet Gynecol 2015; 45: 715-721.


Risk of preterm birth following treatment for cervical disease: Stakeholder meeting summary.

Sasieni P, Castanon A, Landy R, Kyrgiou M, Kitchener H, Quigley M, Poon LC, Shennan A, Paraskevaidis E, Hollingworth A, Soutter P, Freeman Wang T, Peebles D, Prendeville W, Patnick J.

British J Obstet Gynaecol 2015; doi: 10.1111/1471-0528.13839.


Safety of Chinese Herbal Medicines during Pregnancy.

Liang Bo, Li L, Tang LY, Wu Q, Wu XK, Wang CC

J Appl Toxicol 2015;35(5): 447 - 458


Seasonality of Fetal Trisomy 21 - Have Ambient Air Pollutants Played A Role?

Chung MK, Lao TTH, Ting YH, Wong TW, Leung TY

J Matern Fetal Neonatal Med 2015;28(5): 552 - 557


The Effect of a High Progesterone Concentration before Oocyte Retrieval on the Peri-implantation Endometrium.

Liu L, Sailan S, Li TC, Mariee N, Laird S, Jiang Z, Zhang S

Reprod Biomed Online 2015;31(6): 739 - 746


UK NHS pilot study on cell-free DNA testing in screening for fetal trisomies: Factors affecting uptake.

Gil MM, Giunta G, Macalli EA, Poon LC, Nicolaides KH.

Ultrasound Obstet Gynecol 2015; 45: 67-73.


Genetic Diagnosis of Autism Spectrum Disorders: The Opportunity and Challenge in the Genomics Era.

Jiang YH, Wang Y, Xiu X, Choy KW, Pursley AN, Cheung SW

Crit Rev Clin Lab Sci 2014;51(5): 249 - 262


Non-Invasive Prenatal Testing for Fetal Chromosomal Abnormalities by Low-Coverage Whole-Genome Sequencing of Maternal Plasma DNA: Review of 1982 Consecutive Cases in a Single Center.

Lau TK, Cheung SW, Lo PSS, Pursley AN, Chan MK, Jiang F, Zhang H, Wang W, Jong LFJ, Yuen OKC, Chan HYC, Chan WSK, Choy KW

Ultrasound Obst Gyn 2014;43(3): 254 - 264


Recurrent Structural Malformations Identified among Mowat-Wilson Syndrome Fetuses.

Zhou Y, Huang J, Cheng YKY, Leung TY, Pooh RK, Lo FM, Choy KW

Prenatal Diag 2014;34(3): 296 - 298


A Study of the Immune Properties of Human Umbilical Cord Lining Epithelial Cells.

Cai YJ, Huang L, Leung TY, Burd A

Cytotherapy 2014;16(5): 631 - 639


Comparison of the Effect of Penicillins versus Erythromycin in Preventing Neonatal Group B Streptococcus Infection in Active Carriers Following Preterm Prelabor Rupture of Membranes.

Yeung SW, Sahota DS, Leung TY

Taiwan J Obstet Gynecol 2014;53(2): 210 - 214


Does Gestational Diabetes Mellitus Affect Respiratory Outcome in Late-Preterm Infants?

Fung GPG, Chan MLM, Ho Y, To WWK, Chan BHB, Lao TTH

Early Hum Dev 2014;90(9): 527 - 530


Expression Profile of Cord Blood Neutrophils and Dysregulation of HSPA1A and OLR1 upon Challenge by Bacterial Peptidoglycan.

Fong ON, Chan KYY, Leung KT, Lam HS, Cheung HM, Leung TY, Li KKH, Ng PC

J Leukoc Biol 2014;95(1): 169 - 178


Fetal and Maternal Complications in Macrosomic Pregnancies.

Cheng YKY, Lao TTH

Research and Reports in Neonatology 2014;2014(4): 65 - 70


First-trimester contingent screening for trisomies 21, 18 and 13 by biomarkers and maternal blood cell-free DNA testing.

Nicolaides KH, Syngelaki A, Poon LC, Gil M, Wright D.

Fetal Diagn Ther 2014; 35: 185-192.


Maternal Plasma Fetal DNA Fractions in Pregnancies with Low and High Risks for Fetal Chromosomal Aneuploidies.

Hudecova I, Sahota DS, Heung MS, Jin YJ, Lee WS, Leung TY, Lo DYM, Chiu RWK

PLos ONE 2014;9(2): e88484


Potential application of fetal epigenetic markers on the non-invasive prenatal detection of chromosomal abnormality.

Chim SSC

Clin Chem Lab Med 2014;52(5): 585 - 588


A Test of Agreement of Customised Birthweight Models.

Gibbons K, Chang AMZ, Flenady V, Mahomed K, Gray PH, Gardener G, Rossouw D

Paediatr Perinat Epidemiol 2013;27(2): 131 - 137


Bisphenol A Differentially Activates Protein Kinase C Isoforms in Murine Placental Tissue.

Tan WJ, Huang H, Wang YF, Wong TY, Wang CC, Leung LK

Toxicol App Pharm 2013;269(2): 163 - 168


Effect of Zeranol on Expression of Apoptotic and Cell Cycle Proteins in Murine Placentae.

Wang YF, Li L, Wang CC, Leung LK

Toxicology 2013;314(1): 148 - 154


Functional Role of Mst1/Mst2 in Embryonic Stem Cell Differentiation.

Li P, Chen Y, Mak KKL, Wong CK, Wang CC, Yuan P

PLos ONE 2013;8(11): e79867


IL-15 and Macrophage Secretory Factors Facilitate Immune Activation of Neonatal Natural Killer Cells by Lipoteichoic Acid.

Cheng SF, Ho JWY, Chan KYY, Leung TY, Lam HS, Fong ON, Li KKH, Ng PC

Cytokine 2013;61(2): 499 - 505


Melamine in Prenatal and Postnatal Organs in Rats.

Chu NCY, Chu KO, Ho CS, Kwok SS, Chan HMM, Fung KP, Wang CC

Reprod Toxicol 2013;35: 40 - 47


Meta-analysis of second-trimester markers for trisomy 21.

Agathokleous M, Chaveeva P, Poon LC, Kosinski P, Nicolaides KH.

Ultrasound Obstet Gynecol 2013; 41: 247-261.


Noninvasive Prenatal Determination of Twin Zygosity by Maternal Plasma DNA Analysis.

Qu JZZ, Leung TY (co-1st author), Jiang P, Liao GJW, Cheng YKY, Sun H, Chiu RWK, Chan KCA, Lo YM.

Clin Chem 2013; 59:427-35.


Prospective Assessment of the Hong Kong Hospital Authority Universal Down Syndrome Screening Programme.

Sahota DS, Leung WC, Chan WP, To WWK, Lau ET, Leung TY

Hong Kong Med J 2013;19(2): 101 - 108


Second-trimester screening for trisomy 21 using prefrontal space ratio.

Chaveeva P, Agathokleous M, Poon LC, Markova D, Nicolaides KH.

Fetal Diagn Ther 2013; 34: 50-55.


Toxicity of Melamine: The Public Health Concern.

Chu NCY, Wang CC

J Environ SCI Heal C 2013;31(4): 342 - 386


Trichorionic and dichorionic triplet pregnancies at 10-14 weeks: Outcome after embryo reduction compared to expectant management.

Chaveeva P, Kosinski P, Puglia D, Poon L, Nicolaides K.

Fetal Diagn Ther 2013; 1: 199-205.


Use of Birth Weight Threshold for Macrosomia to Identify Fetuses at Risk of Shoulder Dystocia among Chinese Populations.

Cheng YKY, Lao TTH, Sahota DS, Leung VKT, Leung TY

Int J Gynecol Obstet 2013;120(3): 249 - 253


C-reactive protein at 11 to 13 weeks™ gestation in spontaneous early preterm delivery.

Bakalis S, Poon LC, Vayna AM, Pafilis I, Nicolaides KH.

J Matern Fetal Neonatal Med 2012; 25: 2475-2478.


Comparison of Real-time Three-Dimensional Echocardiography and Spatiotemporal Image Correlation in Assessment of Fetal Interventricular Septum.

Xiong Y, Liu T, Wu Y, Xu JF, Ting YH, Leung TY, Lau TK

J Matern Fetal Neonatal Med 2012;25(11): 2333 - 2338


Intrapleural Injection of OK-432 as the Primary In-utero Treatment for Fetal Chylothorax.

Leung VKT, Suen SSH, Ting YH, Law LW, Lau TK, Leung TY

Hong Kong Med J 2012;18(2): 156 - 159


Maternal HBsAg Status and Infant Size - a Faustian Bargain?

Lao TTH, Sahota DS, Suen SSH, Law LW, Leung TY

J Viral Hepatitis 2012;19(7): 519 - 524


Molecular Genetics in Fetal Neurology.

Huang J, Wah YMI, Pooh RK, Choy KW

Semin Fetal Neona M 2012;17(6): 341 - 346


Newborn stem cells: Types, functions and basics for Obstetricians.

Jennifer SM Mak, Juan Bolanos, WC Leung, Richard Boyd, Robert Chin KH

Journal of Paediatrics, Obstetrics & Gynaecology 2012 ;Vol 38 No. 6:247-256


Prenatal Detection of Aneuploidy and Imbalanced Chromosomal Arrangements by Massively Parallel Sequencing.

Dan S, Chen F, Choy KW, Jiang FM, Lin JR, Xuan ZL, Wang W, Chen SP, Li XC, Jiang H, Leung TY, Lau TK, Su Y, Zhang WY, Zhang XQ

PLos ONE 2012;7(2): e27835


Successful Treatment of Severe Fetal Chylothorax Resistant to Repeated Pleuroamniotic Shunting by OK-432 Pleurodesis.

Lo TK, Lau WL, Lam YY, Tang MHY, Leung TY, Leung WC

Fetal Diagn Ther 2012;31(4): 260 - 263



Pan M, Choy KW, Liao C, Lau TK

Chin J Med Genet 2012;29(5): 562 - 565



Liu XX, Lau TK, Wang HF, Wong SM, Leung TY

Chin J Obstet Gynecol 2012;47(8): 587 - 591


Placental and fetal candidiasis associated with intrauterine contraceptive device in situ.

Lee HS, Lo AW.

Pathology. 2011 Apr;43(3):276-7.


Fetal Stromal Niches Enhance Human Embryonic Stem Cell¡VDerived Hematopoietic Differentiation and Globin Switch.

Lee KY, Fong BSP, Tsang KS, Lau TK, Ng PC, Lam AC, Chan KYY, Wang CC, Kung HF, Li CK, Li KKH

Stem Cells Dev 2011;20(1): 31 - 38


Gene Dosage Imbalance of Human Chromosome 21 in Mouse Embryonic Stem Cells Differentiating to Neurons.

Wang CC, Kazuki Y, Oshimura M, Ikeo K, Gojobori T

Gene 2011;481(2): 93 - 101


Interactive Expressions of HtrA1 and VEGF in Human Vitreous Humors and Fetal RPE Cells.

Ng TK, Yam HF, Chen WQ, Lee VYW, Chen H, Chen LJ, Choy KW, Yang Z, Pang CCP

Invest Ophthalmol Vis Sci 2011;52(6): 3706 - 3712


Preterm Birth Rates in Chinese Women in China, Hong Kong and Australia - The Price of Westernisation.

Newnham JP, Sahota DS, Zhang CY, Xu BY, Zheng MM, Doherty DA, Li SF, Chung TKH, Hu YL

Aust NZ J Obstet Gyn 2011;10(5): 426 - 431


Reference range of birth weight with gestation and first-trimester prediction of small for gestation neonates.

Poon LC, Karagiannis G, Staboulidou I, Shafiei A, Nicolaides KH.

Prenat Diagn 2011; 31: 58-65.


The Impact of Fetal Gender on Preterm Birth in a Southern Chinese Population.

Lao TTH, Sahota DS, Suen SSH, Law LW, Leung TY

J Matern Fetal Neonatal Med 2011;24(12): 1440 - 1443


The Use of Three-Dimensional Ultrasound Does Not Improve Training in Fetal Biometric Measurements.

Chan LW, Ting YH, Lao TTH, Chau MMC, Fung TY, Leung TY, Sahota DS, Lau TK

J Matern Fetal Neonatal Med 2011;24(9): 1173 - 1175


Use of Three-Dimensional (3D) Sonography to Assess the True Midsagittal Plane of Fetal Spine.

Yang XH, Chen M, Leung TY, Wong SM, Lau TK

J Matern Fetal Neonatal Med 2011;24(2): 297 - 300


X-Linked Congenital Hypertrichosis Syndrome Is Associated with Interchromosomal Insertions Mediated by a Human-Specific Palindrome near SOX3.

Zhu HW, Shang DD, Sun M, Choi SJ, Liu Q, Hao JJ, Figuera LE, Zhang F, Choy KW, Ao Y, Liu Y, Zhang XL, Yue FZ, Wang MR, Jin L, Patel PI, Jing T, Zhang X

Am J Hum Genet 2011;88(6): 819 - 826


A Novel Mutation of GATA4 in a Familial Atrial Septal Defect.

Chen Y, Mao J, Sun Y, Zhang Q, Cheng HB, Yan WH, Choy KW, Li H

Clin Chim Acta 2010;411(21): 1741 - 1745


Allelic Imbalance at 13q31 is Associated with Reduced GPC6 in Chinese with Sporadic Retinoblastoma.

Lau CSL, Yu CBO, Wong HK, Fan DSP, Mak HT, Wong KW, Lam DSC, Pang CCP, Choy KW

Br J Ophthalmol 2010;94(3): 357 - 363


Assessment of the Fetal Interventricular Septum Using Real-Time Three-Dimensional Echocardiography with Live 3D Imaging.

Xiong Y, Wah YMI, Chen M, Fung TY, Leung TY, Lau TK

Ultrasound Obst Gyn 2010;35(6): 754 - 755


Distribution of Melamine in Rat Foetuses and Neonates.

Chu NCY, Chu KO, Chan JYW, Liu XZ, Ho CS, Wong CK, Lau CM, Ting TL, Fok TF, Fung KP, Wang CC

Toxicol Lett 2010;199(3): 398 - 402


Epigenetic Regulation of Neonatal Cardiomyocytes Differentiation.

Kou CYC, Lau SLC, Au KW, Leung PY, Chim SSC, Fung KP, Waye MMY, Tsui SKW

Biochem Bioph Res Co 2010;400(2): 278 - 283


Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: Neonatal Glycemia.

Metzger BE, Persson B, Lowe LP, Dyer AR, Cruickshank JK, Deerochanawong C, Halliday HL, Hennis AJ, Liley H, Ng PC, Coustan DR, Hadden DR, Hod M, Oats JJN, Trimble ER, The HAPO Study Cooperative Research Group, Chan KY, Chan NY, Ip LW, Kong SL, Lee YL, Li CY, Ng KF, Ng PC, Rogers MS, Wong KW

Pediatrics 2010;126(6): e1545 - e1552


Learning Curve in Measurement of Fetal Frontomaxillary Facial Angle at 11-13 Weeks of Gestation.

Yang X, Chen M, Wang HF, Leung TY, Borenstein M, Nicolaides KH, Sahota DS, Lau TK

Ultrasound Obst Gyn 2010;35(5): 530 - 534


Re: Counseling in Isolated Mild Fetal Ventriculomegaly.

Chan LW, Lau TK

Ultrasound Obst Gyn 2010;35(5): 624 - 625


A strategy for identifying circulating placental RNA markers for fetal growth assessment.

Pang WWI, Tsui MHY, Sahota DS, Leung TY, Lau TK, Lo DYM, Chiu Rossa WK

Prenatal Diag 2009;29(5): 495 - 504


Assessing discrepant findings between QF-PCR on uncultured prenatal samples and karyotyping on long-term culture.

Lau ET, Tang L, Wong C, Lam YH, Ghosh A, Leung WC, Sin WK, Lau TK, Kung YY, Tang MHY

Prenatal Diag 2009;29(2): 151 - 155


Translational Regulation of Glutathione Peroxidase 4 Expression Through Guanine-Rich Sequence-Binding Factor 1 is Essential for Embryonic Brain Development.

Ufer C, Wang CC, Fahling M, Schiebel H, Thiele BJ, Billett EE, Kuhn H, Borchert A

Genes Dev 2008;22(13): 1838 - 1850


Umbilical cord ulceration causing foetal haemorrhage and stillbirth.

Chan SSC, Lau APK, To KF, Leung TY, Lau TK, Leung TN

Hong Kong Med J 2008;14(2): 148 - 151


Gene expression of human fetal retinal ganglion cell during early eye development.

Choy KW, Wong HK, Tang LY, Wang CC, Lau TK, Pang CCP

Asian J Ophthalmol 2007;9(1): 101


Modulation by simvastatin of iberiotoxin-sensitive, Ca2+-activated K+ channels of porcine coronary artery smooth muscle cells.

Seto SW, Au ALS, Lam TY, Chim SSC, Lee SMY, Wan S, Tjiu DCS, Shigemura N, Yim APC, Chan SW, Tsui SKW, Leung GPH, Kwan YW

Brit J Pharmacol 2007;151(7): 987 - 997


Safety Profiles of Chinese Herbal-Medicines in Early Embyro Development.

Wang CC, Lau TK

Clin Chem Lab Med 2007;45: S311


Tea epigallocatechin-3-gallate increases 8-isoprostane level and induces caudal regression in developing rat embryos.

Wang CC, Chu KO, Chong WS, Li WWY, Pang CCP, Shum ASW, Lau TK, Rogers MS

Free Radic Biol Med 2007;43(4): 519 - 527


Uptake and distribution of catechins in fetal organs following in utero exposure in rats.

Chu KO, Wang CC, Chu NCY, Choy KW, Pang CCP, Rogers MS

Hum Reprod 2007;22(1): 280 - 287


Aqueous Humor Levels of Vascular Endothelial Growth Factor and Pigment Epithelium-Derived Factor in Polypoidal Choroidal Vasculopathy and Choroidal Neovascularization.

Tong JP, Chan WM, Liu DTL, Lai TYY, Choy KW, Pang CCP, Lam DSC

Am J Ophthalmol 2006;141(3): 456 - 462


Biases in human papillomavirus genotype prevalence assessment associatedwith commonly used consensus primers.

Chan PKS, Cheung TH, Tam AOY, Lo KWK, Yim SF, Yu MMY, To KF, Wong YF, Cheung JLK, Chan DPC, Hui M, Ip M

Int J Cancer 2006;118(1): 243 - 245


Calcyclin binding protein promotes DNA synthesis and differentiation in rat neonatal cardiomyocytes.

Au KW, Kou CYC, Woo AYH, Chim SSC, Fung KP, Cheng CHK, Waye MMY, Tsui SKW

J Cell Biochem 2006;98(3): 555 - 566


Cord blood thyroid-stimulating hormone level and risk of acidosis at birth.

Chan Louis YS, Fok AWY, Sahota DS, Lau TK

Eur J Obstet Gyn R B 2006;124(2): 173 - 177


Effect of rosiglitazone on embryonic growth and morphology: a study using a whole rat embryo culture model.

Chan Louis YS, Lau TK

Fertil Steril 2006;86(2): 490 - 492


Effects of triamcinolone on the expression of VEGF and PEDF in human retinal pigment epithelial and human umbilical vein endothelial cells.

Tong JP, Lam DSC, Chan WM, Choy KW, Chan KP, Pang CCP

Mol Vis 2006;12: 1490 - 1495


Ex utero intrapartum treatment (EXIT) for congenital giant ranula.

Chan DFY, Lee CH, Fung TY, Chan LW, Abdullah V, Ng PC

Acta Paediatr 2006;95(10): 1303 - 1305


Expression of maspin in gestational trophoblastic disease.

Li HW, Leung SW, Cheung ANY, Yu MMY, Chan LKY, Wong YF

Gynecol Oncol 2006;101(1): 76 - 81


First-trimester maternal serum level of pregnancy-associated plasma protein-A is an independent predictor of fetal maxillary bone length.

Leung TY, Chan LW, Leung TN, Fung TY, Sahota DS, Lau TK

Ultrasound Obst Gyn 2006;27(1): 9 - 12


First-trimester maternal serum levels of placental hormones are independent predictors of second-trimester fetal growth parameters.

Leung TY, Chan LW, Leung TN, Fung TY, Sahota DS, Lau TK

Ultrasound Obst Gyn 2006;27(2): 156 - 161


Left ventricular diastolic function during normal pregnancy: assessment by spectral tissue Doppler imaging.

Fok AWY, Chan Louis YS, Wong JTH, Yu CM, Lau TK

Ultrasound Obst Gyn 2006;28(6): 789 - 793


Metabolomic and bioinformatic analyses in asphyxiated neonates.

Chu NCY, Xiao XM, Zhou XG, Lau TK, Rogers MS, Fok TF, Law LK, Pang CCP, Wang CC

Clin Biochem 2006;39(3): 203 - 209


Prediction of intrapartum Cesarean delivery for non-reassuring fetal status after a successful external cephalic version by a low pre-version pulsatility index of the fetal middle cerebral artery.

Leung TY, Fok AWY, Chan LW, Law LW, Lau TK

Ultrasound Obst Gyn 2006;27(4): 416 - 419


Pro-oxidative effects of tea and polyphenols, epigallocatechin-3-gallate and epigallocatechin, on G6PD-deficient erythrocytes in vitro.

Ko CH, Li KKH, Ng PC, Fung KP, Li CL, Wong RPO, Chui KM, Gu GJS, Yung ECM, Wang CC, Fok TF

Int J Mol Med 2006;18(5): 987 - 994


The utility assessment of Chinese pregnant women towards the birth of a baby with Down syndrome compared to a procedure-related miscarriage.

Chan YM, Leung TN, Leung TY, Fung TY, Chan LW, Lau TK

Prenatal Diag 2006;26(9): 819 - 824


Congenital systemic Langerhans cell histiocytosis presenting as hydrops fetalis.

Lee CH, Lau TK, To KF, Lam HS, Chan AWH, Ng PC

Acta Paediatr 2005;94(12): 1843 - 1847


Detection of the placental epigenetic signature of the maspin gene in maternal plasma.

Chim SSC, Tong YK, Chiu RWK, Lau TK, Leung TN, Chan LYS, Oudejans CB, Ding C, Lo YMD.

Proc Natl Acad Sci USA 2005;102:14753-8. [Cited 191 times]


Development of the Rhombencephalon: Molecular Evolution and Genetic Regulation.

Wang CC

Neuroembryol Aging 2005;3(2): 78 - 91


Effect of prostaglandin E2 for cervical priming on fetal hemodynamics.

Fok AWY, Leung TY, Tsui MHY, Leung TN, Lau TK

J Reprod Med 2005;50(9): 697 - 700


Effects of High-Inspired Oxygen Fraction During Elective Caesarean Section Under General Anaesthesia on Maternal and Fetal Oxygenation and Lipid Peroxidation.

Khaw KS, Ngan Kee WD, Wang CC, Tam WH, Rogers MS

Anaesth Intens Care 2005;33(1): 136


Fetal hemodynamic changes after amniotomy.

Fok AWY, Leung TY, Tsui MHY, Leung TN, Lau TK

Acta Obstet Gyn Scan 2005;84(2): 166 - 169


Impact of hypertensive disorders of pregnancy at term on infant birth weight.

Lau TK, Pang MW, Sahota DS, Leung TN

Acta Obstet Gyn Scan 2005;84(9): 875 - 877


Laparoscopy in a patient with XY gonadal dysgenesis.

Yuen PM, Chan SSC

J Minim Invasive Gynecol 2005;12(3): 194 - 195


Meconium-stained liquor during labor is associated with raised neonatal cord blood 8-iso-prostaglandin F2a concentration.

Liu BY, Wang CC, Lau TK, Chu NCY, Pang CCP, Rogers MS, Leung TN

Am J Obstet Gynecol 2005;192(1): 289 - 294


Pediatric Malignancies: CASE 1. Hypermethylation in Orbital Alveolar Rhabdomyosarcoma.

Chan WM, Liu DTL, Pang CCP, Lam DSC, To KF, Choi PCL, Choy KW, Wong CY, Chan DDN

J Clin Oncol 2005;23(21): 4790 - 4791


Prediction of Outcome of External Cephalic Version for Breech Presentation at Term.

Leung TY, Lau TK

Fetal and Maternal Medicine Review 2005;16(3): 245 - 262


Reference charts of gestation-specific tissue Doppler imaging indices of systolic and diastolic functions in the normal fetal heart.

Chan Louis YS, Fok AWY, Wong JTH, Yu CM, Leung TN, Lau TK

Am Heart J 2005;150(4): 750 - 755


Birth of a healthy baby after transfer of blastocysts derived from cryopreserved human oocytes fertilized with frozen spermatozoa.

Tjer GCC, Chiu TTY, Cheung LP, Lok IH, Haines CJ

Fertil Steril 2005;83(5): 1547 - 1549


A cross-sectional, single-centre study on the levels & sources of mercury, cadmium & lead in a HK mother-infant cohort. (Ref. 212917)

Fok TF, Lam CWK, Yip SK, Sin NC, Ng PC, Leung PHY

HCPF 2004;


A validation study of ultrasonic foetal weight estimation models for Hong Kong Chinese singleton pregnancies.

Pang MW, Leung TN, Lau TK

Hong Kong Med J 2004;10(6): 384 - 388


Cord blood acid-base status at delivery after successful external cephalic version.

Chan Louis YS, Leung TY, Fok AWY, Chan LW, Lau TK

Acta Obstet Gyn Scan 2004;83(5): 436 - 439


Deterioration in cord blood gas status during the second stage of labour is more rapid in the second twin than in the first twin.

Leung TY, Lok IH, Tam WH, Leung TN, Lau TK

BJOG 2004;111(6): 546 - 549


External cephalic version induced fetal cerebral and umbilical blood flow changes are related to the amount of pressure exerted.

Leung TY, Sahota DS, Fok AWY, Chan LW, Lau TK

BJOG 2004;111(5): 430 - 435


Helper T Lymphocyte Related Chemokines in Healthy Newborns.

Leung TF, Ng PC, Tam WH, Li BCY, Wong E, Ma TPY, Lam CWK, Fok TF

Pediatr Res 2004;55(2): 334 - 338


Microsatellite Instability and MLH1 Promoter Methylation in Human Retinoblastoma.

Choy KW, Pang CCP, Fan DSP, Lee TC, Wang JH, Abramson DH, Lo KW, To KF, Yu CBO, Beaverson KL, Cheung KF, Lam DSC

Invest Ophthalmol Vis Sci 2004;45(10): 3404 - 3409


Molecular hierarchy in neurons differentiated from mouse ES cells containing a single human chromosome 21.

Wang CC, Kadota M, Nishigaki R, Kazuki Y, Shirayoshi Y, Rogers MS, Gojobori T, Ikeo K, Oshimura M

Biochem Bioph Res Co 2004;314(2): 335 - 350


Proteomic signatures and aberrations of mouse embryonic stem cells containing a single human chromosome 21 in neuronal differentiation: An in vitro model of down syndrome.

Kadota M, Nishigaki R, Wang CC, Toda T, Shirayoshi Y, Inoue T, Gojobori T, Ikeo K, Rogers MS, Oshimura M

Neuroscience 2004;129(2): 325 - 335


Systematic micro-array based identification of placental mRNA in maternal plasma: towards non-invasive prenatal gene expression profiling

Tsui NBY, Chim SSC, Chiu RWK, Lau TK, Ng EKO, Leung TN, Tong YK, Chan KCA, Lo YMD.

J Med Genet 2004;41:461-7. [Cited 80 times]


Cord blood thyroid-stimulating hormone level in twin pregnancy.

Chan Louis YS, Chiu PY, Lau TK

Acta Obstet Gyn Scan 2003;82(1): 28 - 31


Craniofacial Anthropometry of Hong Kong Chinese Babies: the Eye.

Fok TF, Hon EKL, So HK, Wong E, Ng PC, Lee AKY, Chang AMZ

Orthod Craniofacial Res 2003;6(1): 48 - 53


Customizing fetal biometric charts.

Pang MW, Leung TN, Sahota DS, Lau TK, Chang AMZ

Ultrasound Obst Gyn 2003;22(3): 271 - 276


Development of a Postnatal 3-day-old Rat Model of Mild Hypoxic-Ischemic Brain Injury.

Stadlin A, James AE, Fiscus RR, Wong YF, Rogers MS, Haines CJ

Brain Res 2003;993(1-2): 101 - 110


Facial Anthropometry of Hong Kong Chinese Babies.

Fok TF, Hon EKL, So HK, Wong E, Ng PC, Lee AKY, Chang AMZ

Orthod Craniofacial Res 2003;6(3): 164 - 172


Fetus with Hydropic Change Secondary to Fetal Supraventricular Tachycardia.

Yam MC, Leung TY, Lau TK, Sung RYT

HK J Paediatr 2003;8(2): 130 - 132


First Trimester Human Trophoblast Production Of Placental Corticotrophin-Releasing Hormone (CRH) Is Unresponsive To Hypoxia In-Vitro.

Choy MY, Leung TN, Leung PS, Lau TK

Early Pregnancy: Biology and Medicine 2003;4(1): 235 - 247


Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong.

Chim SSC, Tsui SKW, Chan KCA, Au TC, Hung EC, Tong YK, Chiu RWK, Ng EKO, Chan PK, Chu CM, Sung JJ, Tam JS, Fung KP, Waye MM, Lee CY, Yuen KY and Lo YMD.

Lancet 2003.362:1807-8. [Cited 37 times


mRNA of placental origin is readily detectable in maternal plasma.

Ng EKO, Tsui NBY, Lau TK, Leung TN, Chiu Rossa WK, Panesar NS, Lit LCW, Chan KW, Lo DYM

Proc Natl Acad Sci USA 2003;100(8): 4748 - 4753


Quantifying F2-isoprostanes in umbilical cord blood of newborn by gas chromatography-mass spectrometry.

Chu KO, Wang CC, Rogers MS, Pang CCP

Anal Biochem 2003;316(1): 111 - 117


Updated gestational age specific birth weight, crown-heel length, and head circumference of Chinese newborns.

Fok TF, So HK, Wong E, Ng PC, Chang AMZ, Lau JTF, Chow CB, Lee WH

Arch Dis Child Fetal Neonatal Ed 2003;88(3): F229 - F236


Effects of high inspired oxygen fraction during elective Caesarean section under spinal anaesthesia on maternal and fetal oxygenation and lipid peroxidation.

Khaw KS, Wang CC, Ngan Kee WD, Pang CCP, Rogers MS

Brit J Anaesth 2002;88(1): 18 - 23


Effects of the intensity of downregulation on outcome of in vitro fertilization and embryo transfer.

Lam PM, Cheung LP, Choy CMY, Lau YP, Haines CJ

Gynecol Endocrinol 2002;16(2): 143 - 150


Prenatal exclusion of beta thalassaemia major by examination of maternal plasma.

Chiu Rossa WK, Lau TK, Leung TN, Chow KCK, Chui DHK, Lo DYM

Lancet 2002;360(9338): 998 - 1000


Second-trimester ultrasonographic assessment of the umbilical coiling index.

Qin Y, Lau TK, Rogers MS

Ultrasound Obst Gyn 2002;20(5): 458 - 463


A comparison of fetal behaviour in term fetuses exposed to anticonvulsant medication with unexposed controls.

Kean LH, , Gargari SS, Suwanrath C, Sahota DS, James DK

BJOG 2001;108(11): 1159 - 1163


Computerised analysis of the fetal heart rate and relation to acidaemia at delivery.

Strachan BK, Sahota DS, Wijngaarden WJVan, James DK, Chang AMZ

BJOG 2001;108(8): 848 - 852


Computerized analysis of acute and chronic changes in fetal heart rate variation and fetal activity in association with maternal smoking.

Coppens M, Vindla S, James DK, Sahota DS

Am J Obstet Gynecol 2001;185(2): 421 - 426


Dextran sedimentation in a semi-closed system for the clinical banking of umbilical cord blood.

Tsang KS, Li KKH, Huang DWS, Wong AP, Leung Y, Lau TT, Chang AMZ, Li CK, Fok TF, Yuen PMP

Transfusion 2001;41(3): 344 - 352


Misoprostol's Effect on Uterine Arterial Blood Flow and Fetal Heart Rate in Early Pregnancy.

Yip SK, Tse AOK, Haines CJ, Chung TKH

Obstet Gynecol 2000;95(2): 232 - 235


Comparison of unstimulated and stimulated behaviour in human fetuses with congenital abnormalities.

Vindla S, James DK, Sahota DS

Fetal Diagn Ther 1999;14: 156 - 165


Fetal and maternal level of lipid peroxides in term pregnancies.

Rogers MS, Mongelli JM, Tsang BKH, Wang CC

Acta Obstet Gyn Scan 1999;78(2): 120 - 124


Intapartum fetal hypoxia-reperfusion injury and oligohydramnios: a comparison of three ultrasound estimate of amniotic fluid volume.

Rogers MS, Wang CC

Ultrasound Obst Gyn 1999;12(1): 161


Spontaneous abortion: a randomized, controlled trial comparing surgical evacuation with conservative management using misoprostol.

Chung TKH, Lee DTS, Cheung LP, Haines CJ, Chang AMZ

Fertil Steril 1999;71(6): 1054 - 1059


Computerized Transformation of the Cardiotocographic Paper Record to Its Digital Equivalent for Computerised Analysis. (Chinese Article)

Sahota DS, Yuen PM, Wong YF, Chung TKH, Chang AMZ

Chin J Obstet Gynecol 1998;33(11): 649 - 651


Exposure to angiotensin-converting enzyme inhibitors during first trimester: is it safe to fetus?

Yip SK, Leung TN, Fung HYM

Acta Obstet Gyn Scan 1998;77: 570 - 571


Parvovirus B19-associated hydrops foetalis: the first confirmed case in Hong Kong.

Chan PKS, To KF, Yip SK, Tam JSL, Cheng AFB

Hong Kong Med J 1998;4(3): 321 - 323


Prenatal Diagnosis of cardiac osteoma: a case report.

Fung TY, Lau TK, Yam MC, To KF

Prenatal Diag 1998;18(11): 1209 - 1211


Computerised analysis of behaviour in fetuses with congenital abnormalities.

Vindla S, Sahota DS, Coppens M, James DK

Ultrasound Obst Gyn 1997;9: 302 - 309


Computerised analysis of behaviour in normal and growth-retarded fetuses.

Vindla S, James DK, Sahota DS, Coppens M

Eur J Obstet Gyn R B 1997;75(199): 169 - 175


Computerised Analysis of Fetal Behaviour.

Vindla S, Sahota DS, Coppens M, James DK

Fetal Diagn Ther 1997;12: 319 - 327


Crown-chin length in normal and anencephalic fetuses at 10 to 14 weeks' gestation.

Sepulveda W, Sebire NJ, Fung TY, Pipi E, Nicolaides KH

Am J Obstet Gynecol 1997;176(4): 852 - 855


Fetal bowel dilatation - Report of 3 cases with different perinatal outcomes.

Lau TK, Fung HYM, Fung TY

Aust NZ J Obstet Gyn 1997;37(3): 323 - 324


Fetal diagphragmatic hernia presented with transient unilateral pleural effusion.

Lau TK, Fung HYM, Fung TY

Ultrasound Obst Gyn 1997;9(2): 125 - 127


Pregnancy outcome beyond 41 weeks gestation.

Roach VJ, Rogers MS

Int J Gynecol Obstet 1997;59(1): 19 - 24


The development of a hybrid expert system for the interpretation of fetal acid-base status.

Mongelli JM, Chang AMZ, Sahota DS

Int J Med Infom 1997;44: 135 - 144


The effect of different sampling intervals on the measurement of intrapartum fetal heart rate variability.

Wilcox MA, Wang VW, Sahota DS, Dawkins RR, Chung TKH, Chang AMZ

Obstet Gynecol 1997;89(4): 577 - 580


Urinary D-Glucaric Acid Excretion in Idiopathic Neonatal Jaundice. (Chinese Article)

Sung RYT, Pang CP, Lyon A, Loong EPL, Davies DP

Chin Med J 1997;109: 201 - 205


Birth weight from pregnancies dated by ultrasonography in a multicultural British population.

Wilcox MA, Gardosi JO, Mongelli JM, Ray C, Johnson IR

Brit Med J 1996;307: 588 - 591


Changes in the PR interval -fetal heart rate relationship of the electrocardiogram during fetal compromise in chronically instrumented sheep.

Wijngaarden WJVan, de Haan H, Sahota DS, Haasart T, James DK

Am J Obstet Gynecol 1996;175(3): 548 - 554


Clinical birthweight standards for a total population in the 1980's.

Wilcox MA, Mongelli JM, Gardosi JO

BJOG 1996;101: 178


Gestation-adjusted projection of estimated fetal weight.

Mongelli JM, Gardosi JO

Acta Obstet Gyn Scan 1996;75(1): 28 - 31


Mini-Symposium: Fetal monitoring. Expert systems in perinatal medicine.

Mongelli JM, Rogers MS, Hin LY, Chang AMZ

Curr Opin Obstet Gyn 1996;6: 189 - 193


The effects of parity on birthweight using successive pregnancies.

Wilcox MA, Chang AMZ, Johnson IR

Acta Obstet Gyn Scan 1996;75(5): 453 - 459


A survey of pregnancies that ended in Haemoglobin Bart's hydrops foetalis and Cooley's anaemia.

Leung TN, Li CY, Chang AMZ

Hong Kong Med J 1995;1(3): 273


An adjustable fetal weight standard.

Gardosi JO, Mongelli JM, Wilcox MA, Chang AMZ

Ultrasound Obst Gyn 1995;6: 168 - 174


Localized ileal perforation associated with antenatal sulindac and dexamethasone treatment.

Ng PC, Fung HYM, Yeung CK

Pediatr Surg Int 1995; :


Longitudinal study of fetal growth in subgroups of a low-risk population.

Mongelli JM, Gardosi JO

Ultrasound Obst Gyn 1995;6(5): 340 - 344


Cumulative changes in the fetal electro cardiogram and biochemical indices of fetal hypoxia.

Mohajer MP, Sahota DS, Reed NN, Chang AMZ, Symonds EM, James DK

Eur J Obstet Gyn R B 1994;55: 63 - 70


Intrapartum haemorrhage due to idiopathic rupture of the fetal placental artery.

Tam WH, Haines CJ, Fung HYM

Aust NZ J Obstet Gyn 1994;34(4): 490 - 491


Prediction of caesarean section from ultrasound and clinical assessment of fetal size.

Stock AI, Rogers MS, Wong WM, Chang AMZ

Aust NZ J Obstet Gyn 1994;34(4): 393 - 398


Relative macrosomia' identified by the individualised birthweight ratio a better method of identifying the at risk fetus.

Sanderson DA, Wilcox MA, Johnson IR

Acta Obstet Gyn Scan 1994;73: 246 - 249


Use of the neural network for hypothesis generation in fetal surveillance.

Stock AI, Rogers MS, Chang AMZ, Haines CJ

Baillieres Clin Obstet Gynaecol 1994;8(3): 533 - 548


Insulin like growth factor binding protein-1, glucose tolerance and fetal growth in human pregnancy.

Baldwin SA, Chung TKH, Rogers MS, Chard T, Wang HS

J Endocrinol 1993;136(2): 319 - 325


Neural-tube defect and folic acid status in Hong Kong Chinese.

Wang VW, Chang AMZ

BJOG 1993;100: 1065


Placental bands : a variant of placenta praevia?

Stock AI, Haines CJ, Wong SP, Ghosh A

BJOG 1993;100(9): 863 - 865


Ultrasound estimation of fetal weight: precision or guess work.

Rogers MS, Chung TKH, Chang AMZ

Aust NZ J Obstet Gyn 1993;33: 142 - 144


Transvaginal sonography in the management of cervical incompetence.

Chung TKH, Haines CJ, Kong D, Woo WK, Rogers MS

Gynecol Obstet Inves 1993;36(1): 59 - 61


Customised antenatal growth charts.

Gardosi JO, Kalyan B, Chang AMZ, Sahota DS, Symonds EM

Lancet 1992;339: 283 - 288


Birth-weight of newborns to chinese women subsequent to a previous abortion.

Tan TC, Chang AMZ, Rogers MS

Aust NZ J Obstet Gyn 1990;30: 217 - 221


Coagulation and anticoagulation systems in newborns--correlation with their mothers at delivery. Lower levels of anticoagulants and fibrinolytic activity in the newborn.

Lao TTH, Yin JA, Yuen PMP

Gynecol Obstet Inves 1990;29(3): 181 - 184


Macrosomic babies.

Cheung TH, Leung AKL, Chang AMZ

Aust NZ J Obstet Gyn 1990;30(4): 319 - 322


Non-immune hydrops fetalis.

Li CY, Lao TTH

Asia Oceania J Obstet Gynaecol 1990;16(3): 191 - 199


Zinc and birth weight in uncomplicated pregnancies.

Lao TTH, Loong EPL, Chin RKH, Lam CWK, Lam YM

Acta Obstet Gyn Scan 1990;69: 609 - 611


Birth weight and thyroxine-binding globulin in pre-eclampsia.

Lao TTH, Chin RKH, Panesar NS, Lam YM

Gynecol Obstet Inves 1989;28(1): 8 - 10


Lower incidence of elevated umbilical cord serum IgE concentration in infants of hepatitis B carrier mothers.

Tseng RYM, Lam CWK, Loong EPL, Ho DWY, Davies DP

Acta Paediatr Scand 1989;78: 127 - 128


Renal function in the newborn. Newborn creatinine related to birth weight, maturity and maternal creatinine.

Lao TTH, Loong EPL, Chin RKH, Lam YM

Gynecol Obstet Inves 1989;28(2): 70 - 72


Low birth weight and hyperemesis gravidarum.

Chin RKH, Lao TTH

Eur J Obstet Gyn R B 1988;28(3): 179 - 183


Transient hyperthyroidism in a pregnancy with hydrops fetalis.

Lao TTH, Chin RKH, Chan AC

BJOG 1988;95(6): 624 - 625


Cretinism and lingual thyroid presenting in an adult.

Yeung VTF, Loong EPL, Cockram CS

Postgrad Med J 1987;63: 881 - 883


Determinants of birth-weight in the New Territories of Hong Kong.

Rogers MS, Wong FWS, Chang AMZ

Aust NZ J Obstet Gyn 1987;27(4): 314 - 319


Intestinal parasitism: A survey of patients attending an antenatal clinic in the New Territories of Hong Kong.

Rogers MS, French GL, Chang AMZ

Asia Oceania J Obstet Gynaecol 1987;13: 461 - 466


Perinatal asphyxia: The use of Path Analysis in its explanation.

Rogers MS, Chang AMZ

J Obstet Gynaecol 1987;8: 29 - 35


Plasma zinc concentration and thyroid function in hyperemetic pregnancies.

Lao TTH, Chin RKH, Mak YT, Panesar NS

Eur J Obstet Gyn R B 1987;30(2): 117 - 122


The outcome of hyperemetic pregnancies complicated by transient hyperthyroidism.

Lao TTH, Chin RKH, Chang AMZ

Aust NZ J Obstet Gyn 1987;27(2): 99 - 101


Umbilical cord serum IgE in infants of hepatitis B carrier mothers.

Loong EPL, Tseng RYM, Lam CWK, Ho DWY, Davies DP

Allergologia et Immunopathologia 1987;15: 239


Zinc concentration in umbilical cord tissue and cord plasma in appropriate for gestational age babies.

Wong FWS, Arumanayagam M, Chang AMZ, Swaminathan SR

Eur J Obstet Gyn R B 1986;23: 121 - 126


An evaluation of three ultrasound equations for fetal weight prediction.

Wong FWS, Rogers MS, Chang AMZ

Aust NZ J Obstet Gyn 1985;25: 271 - 272


Any place for antenatal diagnosis in the third trimester of pregnancy?

Lao TTH, Loong EPL, Yeung SSL

Clin Exp Obstet Gynecol 1985;12(3): 51 - 52


Evaluation of fundal height measurement inantenatal care.

Rogers MS, Needham PG

Aust NZ J Obstet Gyn 1985;25: 87 - 90


The limitations of ultrasonography in the antenatal diagnosis of congenital cerebral malformations.

Loong EPL, Lao TTH

Gynecol Obstet Inves 1985;19(3): 166 - 168


Antenatal diagnosis of intracranial arteriovenous fistula by ultrasonography.

Mao KR, Adams J

BJOG 1983;90(9): 872 - 873