Academic Publications in Perinatal Medicine


Accurate Description of DNA-based Noninvasive Prenatal Screening.

Cheung SW, Petal A, Leung TY

N Engl J Med 2015;372(17): 1675 - 1677


Effect of Assisted Reproductive Technology on Fetal Brain Development Assessed by Prenatal Ultrasonography.

Yin L, Xu Y, Li H, Ling C, Choy KW, Xia F, Deng X

J Perinat Med 2015;43(1): 103 - 109


Ethical Concerns in the Implementation of DNA Sequencing-based Noninvasive Prenatal Testing for Fetal Aneuploidy Among Obstetric Professionals in Hong Kong.

Yi H, NganOMY, Griffiths S, Sahota DS

Am. J Bioeth 2015;6(1): 81 - 93


Noninvasive Prenatal Testing by Nanopore Sequencing of Maternal Plasma DNA: Feasibility Assessment.

Cheng SH, Jiang PY, Sun K, Cheng YKY, Chan AKC, Leung TY, Chiu RWK, Lo DYM

Clin Chem 2015;61(10): 1305 - 1306


Noninvasive Testing for Fetal Aneuploidy: A Hong Kong Perspective.

Sahota DS

Am. J Bioeth 2015;6(1): 106 - 110


Plasma DNA Tissue Mapping by Genome-Wide Methylation Sequencing for Noninvasive Prenatal, Cancer, and Transplantation Assessments.

Sun K, Jiang PY, Chan AKC, Wong J, Cheng YKY, Liang RHS, Chan WK, Ma ESK, Chan SL, Cheng SH, Chan RWY, Tong YK, Ng SSM, Wong RSM, Hui DSC, Leung TN, Leung TY, Lai PBS, Chiu RWK, Lo DYM

Proc Natl Acad Sci USA 2015;112(40): e5503 - e5512


Prenatal Diagnosis of 24 Cases of Microduplication 22q11.2: An Investigation of Phenotype-genotype Correlations.

Dupont C, Grati F, Choy KW, Jaillard S, Toutain J, Maurin ML, Martinez-Conejero JA, Beneteau C, Coussement A, Molinagomes D, Horelli-Kuitunen N, Aboura A, Tabet AC, Besseau-Ayasse J, Bessieres GB, Simoni G, Ayala G, Benzacken B, Vialard F

Prenatal Diag 2015;35(1): 35 - 43


Prevalence of Recurrent Pathogenic Microdeletions and Microduplications in Over 9500 Pregnancies.

Grati F, Gomes DM, Ferreira JCPB, Dupont C, Alesi V, Gouas L, Horelli-Kuitunen N, Choy KW, Garcia-Herrero S, Gonzalez de la Vega A, Piotrowski K, Genesio R, Queipo G, Malvestiti B, Herve B, Benzacken B, Novelli A, Vago P, Piippo K, Leung TY, Maggi F, Quibel T, Tabet AC, Simoni G, Vialard F

Prenatal Diag 2015;35(8): 801 - 809


TBX6 Null Variants and a Common Hypomorphic Allele in Congenital Scoliosis.

Wu N, Ming X, Xiao J, Wu Z, Chen X, Shinawi M, Shen Y, Yu G, Liu J, Xie H, Gucev ZS, Liu S, Yang N, AI-Kateb H, Chen J, Zhang J, Hauser N, Zhang T, Tasic V, Liu P, Su X, Pan X, Liu C, Wang L, Shen J, Chen Y, Zhang T, Zhang J, Choy KW, Wang J, Wang Q, Liu S, Zhou W, Guo J, Wang Y, Zhang C

N Engl J Med 2015;372(4): 341 - 350


Women's Uptake of Non-Invasive DNA Testing Following a High-risk Screening Test for Trisomy 21 within a Publicly Funded Healthcare System Findings from a Retrospective Review.

Chan OYM, Leung WC, Chan WP, Leung TY, Cheng YKY, Sahota DS

Prenatal Diag 2015;35(4): 342 - 347


A Patient with Five Chromosomal Rearrangement and a 2q31.1 Microdeletion.

Wang T, Mao J, Liu MJ, Choy KW, Li HB, Cram DS, Li H, Chen Y

Clin Chim Acta 2014;2014(430C): 129 - 133


A Robust Approach for Blind Detection of Balanced Chromosomal Rearrangements with Whole-Genome Low-Coverage Sequencing.

Dong Z, Jiang LP, Yang CC, Hu H, Wang XH, Chen HX, Choy KW, Hu HM, Dong YL, Hu B, Xu JC, Long Y, Cao SJ, Chen H, Wang WJ, Jiang H, Xu FP, Yao H, Xu X, Liang ZQ

Hum Mutat 2014;35(5): 625 - 636


BACs-on-beads A New Robust and Rapid Detection Method For Prenatal Diagnosis.

Choy KW, Chen Y, Sun XF, Kwok YKY, Leung TY

Expert Rev Mol Diagn 2014;14(3): 273 - 280


Diagnostic accuracy of the BACs-on-Beads™ assay versus karyotyping for prenatal detection of chromosomal abnormalities: a retrospective consecutive case series.

Choy K, Kwok Y, Cheng Y, Wong K, Wong H, Leung K, Suen K, Adler K, Wang C, Lau T, Schermer M, Lao T, Leung TY.

BJOG 2014; 121:1245-52.


Is High Fetal Nuchal Translucency Associated with Submicroscopic Chromosomal Abnormalities by Array CGH?

Huang J, Poon LC, Akolekar R, Choy KW, Leung TY, Nicolaides KH.

Ultrasound Obstet Gynecol 2014; 43: 620-624.


Patient's Choice between a Non-invasive Prenatal Test and Invasive Prenatal Diagnosis Based on Test Accuracy.

Chan OYM, Leung TY, Chan OK, Cheng YKY, Sahota DS

Fetal Diagn Ther 2014;35(3): 193 - 198


Performance of Chromosomal Microarray for Patients with Intellectual Disabilities/Developmental Delay, Autism, and Multiple Congenital Anomalies in a Chinese Cohort.

Chong WS, Lo FM, Lam STS, Wang CC, Luk HM, Leung TY, Choy KW

Mol Cytogenet 2014;7(34): 1 - 6


Prenatal Diagnosis of Maternally Inherited X-linked Opitz G/BBB Syndrome by Chromosomal Microarray in a Fetus with Complex Congenital Heart Disease.

Cheng YKY, Huang J, Law KM, Chan OYM, Leung TY, Choy KW

Clin Chim Acta 2014;436C(2014): 140 - 142


PSCC: Sensitive and Reliable Population-Scale Copy Number Variation Detection Method Based on Low Coverage Sequencing.

Li XC, Chen SP, Xie WW, Vogel I, Choy KW, Chen F, Christensen R, Zhang CL, Ge HJ, Jiang HJ, Yu C, Huang F, Jiang H, Zhang XQ

PLos ONE 2014;9(1): e85096


Size-based Molecular Diagnostics Using Plasma DNA for Noninvasive Prenatal Testing.

Yu JCY, Chan AKC, Zheng YWL, Jiang PY, Liao GJW, Sun H, Akolekar R, Leung TY, Go ATJI, van Vugt JMG, Minekawa R, Oudejans CBM, Nicolaides KH, Chiu RWK, Lo DYM

Proc Natl Acad Sci USA 2014;111(23): 8583 - 8588


Trends in Preterm Birth in Singleton Deliveries in a Hong Kong Population.

Hui ASY, Lao TTH, Leung TY, Schaaf JM, Sahota DS

Int J Gynecol Obstet 2014;7292(14): 248 - 253


Can Live xPlane Imaging of the In-plane View of Interventricular Septum be Used to Detect Fetal Conotruncal Anomalies?

Xiong Y, Liu T, Gan HJ, Wu Y, Xu JF, Ting YH, Leung TY, Lau TK

J Matern Fetal Neonatal Med 2013;26(4): 373 - 377


Carbimazole Embryopathy in a Chinese Population: Case Series and Literature Review.

Ting YH, Zhou Y, Lao TTH

Birth Defects Res Part A-Clin Mol Teratol 2013;97(4): 225 - 229


Detection of the Fetal Conotruncal Anomalies Using Real-time Three-dimensional Echocardiography with Live Xplane Imaging of the Fetal Ductal Arch View.

Xiong Y, Liu T, Gan HJ, Wu Y, Xu JF, Ting YH, Leung TY, Lau TK

Prenatal Diag 2013;33(5): 462 - 466


First-trimester Cystic Hygroma: Relationship of Nuchal Translucency Thickness and Outcomes.

Huang J, Leung TY, Choy KW

Obstet Gynecol 2013;121(1): 192 - 193


Melamine Toxicity in Rat Foetuses and Infants.

Wang CC, Fung KP, Fok TF, Lau TK, Pang CP, Chu KO, Shum ASW, Lam CWK, Chan MHM, Ho CS, Lau CM, Ting TL, Mak TCW

Hong Kong Med J 2013;19(S8): S20 - S22


Motivations for Undertaking DNA Sequencing-based Non-invasive Prenatal Testing for Fetal Aneuploidy: A Qualitative Study with Early Adopter Patients in Hong Kong.

Yi H, Hallowell N, Griffiths S, Leung TY

PLos ONE 2013;8(11): e81794


Noninvasive Prenatal Molecular Karyotyping from Maternal Plasma.

Yu JCY, Jiang PY, Choy KW, Chan AKC, Won HS, Leung WC, Lau ET, Tang MHY, Leung TY, Lo DYM, Chiu RWK

PLos ONE 2013;8(4): e60968


Noninvasive Twin Zygosity Assessment and Aneuploidy Detection by Maternal Plasma DNA Sequencing.

Leung TY, Qu JZZ, Liao GJW, Jiang PY, Cheng YKY, Chan AKC, Chiu RWK, Lo DYM

Prenatal Diag 2013;33(7): 675 - 681


Radiofrequency Ablation for Selective Reduction in Complicated Monochorionic Multiple Pregnancies.

Lu J, Ting YH, Law KM, Lau TK, Leung TY

Fetal Diagn Ther 2013;34(4): 211 - 216


Role of B Lymphoma Mo-MLV Insertion Region 1 in the Oncogenic Behavior of Retinoblastomas.

Ren RJ, Liu WW, Huang L, Liu DTL, Choy KW, Shi JT, Zhao JY, Zhao BW, Guan M, Shields CL, Pang CP, Li B, Yam GHF

Mol Vis 2013;19: 561 - 574


Secondary Findings from Non-invasive Prenatal Testing for Common Fetal Aneuploidies by Whole Genome Sequencing as A Clinical Service.

Lau TK, Jiang FM, Stevenson RJ, Lo TK, Chan LW, Chan MK, Lo SPS, Wang W, Zhang H, Chen F, Choy KW

Prenatal Diag 2013;33(6): 602 - 608


Single Fetal Cells for Non-Invasive Prenatal Genetic Diagnosis: Old Myths New Prospective.

Chan WK, Kwok YKY, Choy KW, Leung TY, Wang CC

Medical Journal of Obstetrics and Gynecology 2013;1(1): 1004


The Detection of Mosaicism by Prenatal BoBs TM.

Cheng YKY, Wong CKM, Wong HK, Leung Kwok On, Kwok YKY, Suen AKW, Wang CC, Leung TY, Choy KW

Prenatal Diag 2013;33(1): 42 - 49


The Influence of Image Setting on Intracranial Translucency Measurement by Manual and Semi-automated System.

Zhen L, Yang X, Ting YH, Chen M, Leung TY

Prenatal Diag 2013;33(9): 889 - 893


A Fetus with a Huge Neck Mass and a Large Abdominal Circumference - A Rare Case of Sialoblastoma and Hepatoblastoma.

Cheng YKY, Chu WCW, Law LW, Ting YH, Leung TY

Prenatal Diag 2012;32(9): 915 - 917


A Novel Way of Visualizing the Ductal and Aortic Arches by Real-time Three-dimensional Ultrasound with Live xPlane Imaging.

Xiong Y, Chen M, Chan LW, Ting YH, Fung TY, Leung TY, Lau TK

Ultrasound Obst Gyn 2012;39(3): 316 - 321


Can We Use the Frontomaxillary Facial Angle in the First Trimester to Predict Facial Cleft?

Pan M, Chen M, Sahota DS, Lao TTH, Lau TK, Leung TY

Prenatal Diag 2012;32(5): 491 - 493


Effect of Image Settings on Nuchal Translucency Thickness Measurement by a Semi-automated System.

Chen PW, Chen M, Leung TY, Lau TK

Ultrasound Obst Gyn 2012;39(2): 169 - 174


First Trimester Serum Markers Stability during Sample Transportation from the Obstetrical Site to the Screening Laboratory.

Sahota DS, Pooh RK, Choy KW, Leung TY, Lau TK

J Matern Fetal Neonatal Med 2012;25(7): 966 - 969


Has Improved Health Care Provision Impacted on the Obstetric Outcome in Teenage Women?

Lao TTH, Suen SSH, Sahota DS, Law LW, Leung TY

J Matern Fetal Neonatal Med 2012;25(8): 1358 - 1362


High Resolution Size Analysis of Fetal DNA in the Urine of Pregnant Women by Paired-end Massively Parallel Sequencing.

Tsui NBY, Jiang PY, Chow KCK, Su XX, Leung TY, Sun H, Chan AKC, Chiu RWK, Lo DYM

PLos ONE 2012;7(10): e48319


Normal Range of Intractranial Translucency (IT) Assessed by Three-dimensional Ultrasound at 11+0 to 13+6 Weeks in a Chinese Population.

Chen M, Chen H, Yang X, Wang HF, Leung TY, Sahota DS, Lao TTH, Lau TK

J Matern Fetal Neonatal Med 2012;25(5): 489 - 492


Quality Assurance of Nuchal Translucency for Prenatal Fetal Down Syndrome Screening.

Sahota DS, Leung WC, To WWK, Chan WP, Lau TK, Leung TY

J Matern Fetal Neonatal Med 2012;25(7): 1039 - 1043


Scan the Fetal Heart by Real-time Three-dimensional Echocardiography with Live xPlane Imaging.

Xiong Y, Chen M, Chan LW, Ting YH, Fung TY, Leung TY, Lau TK

J Matern Fetal Neonatal Med 2012;25(4): 324 - 328


Systematic Identification of Spontaneous Preterm Birth-Associated RNA Transcripts in Maternal Plasma.

Chim SSC, Lee WS, Ting YH, Chan OK, Lee SWY, Leung TY

PLos ONE 2012;7(4): e34328


Technical Concerns about Immunoprecipitation of Methylated Fetal DNA for Noninvasive Trisomy 21 Diagnosis.

Tong YK, Chiu RWK, Chan AKC, Leung TY, Lo DYM

Nat Med 2012;18(9): 1327 - 1328


2010 Report from the ISPD Special Interest Groups.

Odibo AO, Faas BHW, Oepkes D, Leung TY, Lee SM

Prenatal Diag 2011;31: 246 - 248


Assessment of Sonographer Nuchal Translucency Measurement Performance - Central Tendency and Dispersion.

Sahota DS, Chen M, Leung TY, Chan LW, Fung TY, Ting YH, Lau TK

J Matern Fetal Neonatal Med 2011;24(6): 812 - 816


First Trimester Screening - New Directions for Antenatal Care?

Chitty LS, Lau TK

Prenatal Diag 2011;31(1): 1 - 2


Frontomaxillary Facial Angle at 11+0 to 13+6 Weeks in Chinese Population.

Chen M, Wang HF, Leung TY, Sahota DS, Borenstein M, Nicolaides KH, Lao TTH, Lau TK

J Matern Fetal Neonatal Med 2011;24(3): 498 - 501


Isolated Absent or Hypoplastic Nasal Bone in the Second Trimester Fetus: is Amniocentesis Necessary?

Ting YH, Lao TTH, Lau TK, Chung MK, Leung TY

J Matern Fetal Neonatal Med 2011;24(4): 555 - 558


Molecular Basis of Von Hippel-Lindau Syndrome in Chinese Patients.

Siu WK, Ma RCW, Lam CW, Mak CM, Yuen YP, Lo FMI, Chan KW, Lam SF, Ling SC, Tong SF, So WY, Chow CC, Tang MHY, Tam WH, Chan AYW

Chin Med J 2011;124(2): 237 - 241


Non-Invasive Prenatal Assessment of Trisomy 21 by Multiplexed Maternal Plasma DNA Sequencing : Large Scale Validity Study.

Chiu RWK, Akolekar R, Zheng YWL, Leung TY, Sun H, Chan AKC, Lun FMF, Go ATJI, Lau ET, To WWK, Leung WC, Tang RYK, Au Yeung KC, Lam H, Kung YY, Zhang XQ, Van Vugt JMG, Minekawa R, Tang MHY, Wang J, Oudejans CBM, Lau TK, Nicolaides KH, Lo DYM

Brit Med J 2011;342: c7401


Noninvasive Prenatal Diagnosis of Hemophilia by Microfluidics Digital PCR Analysis of Maternal Plasma DNA.

Tsui NBY, Kadir RA, Chan AKC, Chi C, Mellars G, Tuddenham EG, Leung TY, Lau TK, Chiu RWK, Lo DYM

Blood 2011;117(13): 3684 - 3691


Placental Site in The Second Trimester of Pregnancy and Its Association with Subsequent Obstetric Outcome.

Fung TY, Sahota DS, Lau TK, Leung TY, Chan LW, Chung TKH

Prenatal Diag 2011;31(6): 548 - 554


Prenatal Diagnosis of Morbidly Adherent Placenta.

Lau TK, Leung TY

Int J Obstet Anesth 2011;20(2): 107 - 109


The Use of Three-Dimensional Ultrasound Does Not Improve Training in Fetal Biometric Measurements.

Chan LW, Ting YH, Lao TTH, Chau MMC, Fung TY, Leung TY, Sahota DS, Lau TK

J Matern Fetal Neonatal Med 2011;24(9): 1173 - 1175


Use of Three-Dimensional (3D) Sonography to Assess the True Midsagittal Plane of Fetal Spine.

Yang XH, Chen M, Leung TY, Wong SM, Lau TK

J Matern Fetal Neonatal Med 2011;24(2): 297 - 300


採用微陣列 - 比較基因組雜交進行產前診斷的局限性和困難

Chen Y, Choy KW




Chen M, Hu ZY, Lau TK

Chinese Journals of Practical Medicine 2011;27(4): 105 - 108


Assessment of the Fetal Interventricular Septum Using Real-Time Three-Dimensional Echocardiography with Live 3D Imaging.

Xiong Y, Wah YMI, Chen M, Fung TY, Leung TY, Lau TK

Ultrasound Obst Gyn 2010;35(6): 754 - 755


Comparison of First-Trimester Contingent Screening Strategies for Down Syndrome.

Sahota DS, Leung TY, Chan LW, Law LW, Fung TY, Chen M, Lau TK

Ultrasound Obst Gyn 2010;35(3): 286 - 291


Comparison of Likehood Ratios of First-Trimester Nuchal Translucency Measurements: Multiples of Median, Delta or Mixture.

Sahota DS, Leung TY, Chen M, Chan LW, Fung TY, Lau TK

Ultrasound Obst Gyn 2010;36(1): 15 - 19


Learning Curve in Measurement of Fetal Frontomaxillary Facial Angle at 11-13 Weeks of Gestation.

Yang X, Chen M, Wang HF, Leung TY, Borenstein M, Nicolaides KH, Sahota DS, Lau TK

Ultrasound Obst Gyn 2010;35(5): 530 - 534


Re: Counseling in Isolated Mild Fetal Ventriculomegaly.

Chan LW, Lau TK

Ultrasound Obst Gyn 2010;35(5): 624 - 625


Real-Time Three-Dimensional Ultrasound with Live xPlane Imaging Assists First-Trimester Acquisition of a True Midsagittal Section.

Xiong Y, Wah YMI, Chan LW, Leung TY, Fung TY, Lau TK

Ultrasound Obst Gyn 2010;36(2): 136 - 140


Systematic Identification of Placental Epigenetic Signatures for the Noninvasive Prenatal Detection of Edwards Syndrome.

Tsui DWY, Lam DYM, Lee CWS, Leung TY, Lau TK, Lau ET, Tang MHY, Akolekar R, Nicolaides KH, Chiu RWK, Lo DYM, Chim SSC

PLos ONE 2010;5(11): e15069


The Impact of Human Copy Number Variation on a New Era of Genetic Testing.

Choy KW, Setlur SR, Lee C, Lau TK

BJOG 2010;117(4): 391 - 398



Lau TK, Leung TY, Chen M, Liao C

Chin J Obstet Gynecol 2010;45(6)



Lau TK, Leung TY, Chen M, Liao C

Chin J Obstet Gynecol 2010;45(10): 732 - 734


A survey of prenatal first-trimester aneuploidy screening among Hong Kong specialist obstetricians.

Chan OYM, Sahota DS, Chan OK, Leung TY, Lau TK

Hong Kong Med J 2009;15(6): 447 - 451


Assessing discrepant findings between QF-PCR on uncultured prenatal samples and karyotyping on long-term culture.

Lau ET, Tang L, Wong C, Lam YH, Ghosh A, Leung WC, Sin WK, Lau TK, Kung YY, Tang MHY

Prenatal Diag 2009;29(2): 151 - 155


Chinese women's preferences for prenatal diagnostic procedure and their willingness to trade between procedures.

Chan OYM, Sahota DS, Leung TY, Choy KW, Chan OK, Lau TK

Prenatal Diag 2009;29(13): 1270 - 1276


De novo 16p13.11 microdeletion identified by high-resolution array CGH in a fetus with increased nuchal translucency.

Law LW, Lau TK, Fung TY, Leung TY, Wang CC, Choy KW

BJOG 2009;116(2): 339 - 343


Development of extraction protocols to improve the yield for fetal RNA in maternal plasma.

Heung MS, Tsui NBY, Leung TY, Lau TK, Lo DYM, Chiu Rossa WK

Prenatal Diag 2009;29(3): 277 - 279


First trimester measurements of nasal bone length using three-dimensional ultrasound.

Chen M, Wang HF, Leung TY, Fung TY, Chan LW, Sahota DS, Lao TTH, Lau TK

Prenatal Diag 2009;29(8): 766 - 770


Gastroschisis Associated with an Intra-abdominal Umbilical Vein Varix: A Report of 2 Cases.

Fung TY, Chan LW, Leung TY, Lau TK

Fetal Diagn Ther 2009;25(4): 404 - 406


Medians and correction factors for biochemical and ultrasound markers in Chinese women undergoing first-trimester screening for trisomy 21.

Sahota DS, Leung TY, Fung TY, Chan LW, Law LW, Lau TK

Ultrasound Obst Gyn 2009;33(4): 387 - 393


Miscarriage after invasive prenatal diagnostic procedures: how much risk our pregnant women are willing to take?

Chan OYM, Sahota DS, Chan OK, Leung TY, Lau TK

Prenatal Diag 2009;29(9): 870 - 874


Monozygotic Dichorionic Twins Heterokaryotypic for Duplication Chromosome 2q13-q23.3.

Leung WC, Choi H, Lau WL, Ng LKI, Lau ET, Lo FM, Choy KW, Lau TK, Tang MHY, Chin RKH

Fetal Diagn Ther 2009;25(4): 397 - 399


Non-invasive Prenatal Diagnosis: From Dream to Reality.

Lau TK, Leung TY

JPOG 2009;35(3): 125 - 131


Prenatal findings and delineation of de novo concurrent partial trisomy 7q(7q31.2 --> qter) and partial monosomy 6q(6q26 --> qter) by high-resolution array CGH.

Choy KW, Chan LW, Tang MHY, Ng LKI, Leung TY, Lau TK

J Matern Fetal Neonatal Med 2009;22(11): 1014 - 1020


Real-time three-dimensional echocardiography using a matrix probe with live xPlane imaging of the interventricular septum.

Xiong Y, Wah YMI, Chen M, Leung TY, Lau TK

Ultrasound Obst Gyn 2009;34(5): 534 - 537


Sonographic features of anorectal atresia at 12 weeks.

Chen M, Meagher S, Simpson I, Lau TK

J Matern Fetal Neonatal Med 2009;22(10): 931 - 933


Study on the applicability of frontomaxillary facial angle in the first-trimester trisomy 21 fetuses in Chinese population.

Chen M, Yang X, Leung TY, Sahota DS, Fung TY, Chan LW, Lao TTH, Lau TK

Prenatal Diag 2009;29(12): 1141 - 1144


The Effect of Volume of Chorionic Villi on Long-Term Cell Culture.

Chen M, Ng LKI, Lau ET, Lee CP, Tang MHY, Lam YH

Fetal Diagn Ther 2009;24(4): 409 - 412


Ultrasound screening for fetal structural abnormalities performed by trained midwives in the second trimester in a low-risk population-an appraisal.

Chen M, Leung TY, Sahota DS, Fung TY, Chan LW, Law LW, Chau MMC, Lao TTH, Lau TK

Acta Obstet Gyn Scan 2009;88(6): 713 - 719


Volumetric (3D) imaging reduces inter- and intraobserver variation of fetal biometry measurements.

Chan LW, Fung TY, Leung TY, Sahota DS, Lau TK

Ultrasound Obst Gyn 2009;33(4): 447 - 452


A prospective study on the effect of rapid aneuploidy testing (amnio-PCR) on anxiety levels and quality of life measures in women and their partners with positive Down screening result.

Leung WC, Lau ET, Ngai C, Lam H, Leung KY, Lee CP, Lao TTH, Tang MHY

Fetal Diagn Ther 2008;24(3): 165 - 169


Expectation and Knowledge of Pregnant Women Undergoing First and Second Trimester Ultrasound Examination in a Chinese Population.

Chan LW, Chan OK, Chau MMC, Sahota DS, Leung TY, Fung TY, Lau TK

Prenatal Diag 2008;28(8): 739 - 744


Fetal Biometry in Ethnic Chinese: Biparietal Diameter, Head Circumference, Abdominal Circumference and Femur Length.

Leung TN, Pang MW, Sahota DS, Leung TY, Poon CF, Wong SM, Lau TK

Ultrasound Obst Gyn 2008;31(3): 321 - 327


Fetal nasal bone status in Chinese women undergoing first-trimester screening for trisomy 21.

Leung TY, Sahota DS, Chan LW, Law LW, Fung TY, Lau TK

Am J Obstet Gynecol 2008;199(5): 521.e1 - 521.e5


How true is a 'true' midsagittal section?

Wah YMI, Chan LW, Leung TY, Fung TY, Lau TK

Ultrasound Obst Gyn 2008;32(7): 855 - 859


Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma.

Chiu Rossa WK, Chan AKC, Gao Y, Lau VYM, Zheng W, Leung TY, Foo CHF, Xie B, Tsui NBY, Lun FMF, Zee BCY, Lau TK, Cantor CR, Lo DYM

Proc Natl Acad Sci USA 2008;105(51): 20458 - 20463


Noninvasive prenatal diagnosis of monogenic diseases by digital size selection and relative mutation dosage on DNA in maternal plasma.

Lun FMF, Tsui NBY, Chan AKC, Leung TY, Lau TK, Charoenkwan P, Chow KCK, Lo WYW, Wanapirak C, Sanguansermsri T, Cantor CR, Chiu Rossa WK, Lo DYM

Proc Natl Acad Sci USA 2008;105(50): 19920 - 19925


Prediction of birth weight by fetal crown-rump length and maternal serum levels of pregnancy-associated plasma protein-A in the first trimester.

Leung TY, Sahota DS, Chan LW, Law LW, Fung TY, Leung TN, Lau TK

Ultrasound Obst Gyn 2008;31(1): 10 - 14


Prenatal Screening for Retinoblastoma in Hong Kong.

Lau CSL, Choy KW, Fan DSP, Yu CBO, Wong CY, Lam DSC, Pang CCP

Hong Kong Med J 2008;14(5): 391 - 394


Screening for Trisomy 21 by Maternal Age, Fetal Nuchal Translucency Thickness, Free Beta-Human Chorionic Gonadotropin and Pregnancy-Associated Plasma Protein-A.

Kagan KO, Wright D, Baker A, Sahota DS, Nicolaides KH

Ultrasound Obst Gyn 2008;31(6): 618 - 624


Second-Trimester Sonographic Soft Markers: What Can We Learn From the Experience of First-Trimester Nuchal Translucency Screening?

Lau TK, Evans MI

Ultrasound Obst Gyn 2008;32(2): 123 - 125


Umbilical cord ulceration causing foetal haemorrhage and stillbirth.

Chan SSC, Lau APK, To KF, Leung TY, Lau TK, Leung TN

Hong Kong Med J 2008;14(2): 148 - 151


First-trimester combined screening for trisomy 21 in a predominantly Chinese population.

Leung TY, Chan LW, Leung TN, Fung TY, Sahota DS, Spencer K, Lau TK

Ultrasound Obst Gyn 2007;29(1): 14 - 17


Microphthalmos Associated with Dartmouth Combination Chemotherapy in Pregnancy.

Li HW, Tam WH, Ng PC, Mok TSK, Tam BSM, Lau TK

J Reprod Med 2007;52(6): 575 - 576


Quantitative aberrations of hypermethylated RASSF1A gene sequences in maternal plasma in pre-eclampsia.

Tsui DWY, Chan AKC, Chim SSC, Chan LW, Leung TY, Lau TK, Lo DYM, Chiu Rossa WK

Prenatal Diag 2007;27(13): 1212 - 1218


Ex utero intrapartum treatment (EXIT) for congenital giant ranula.

Chan DFY, Lee CH, Fung TY, Chan LW, Abdullah V, Ng PC

Acta Paediatr 2006;95(10): 1303 - 1305


Left ventricular diastolic function during normal pregnancy: assessment by spectral tissue Doppler imaging.

Fok AWY, Chan Louis YS, Wong JTH, Yu CM, Lau TK

Ultrasound Obst Gyn 2006;28(6): 789 - 793


Risk factors for procedure-related fetal losses after mid-trimester genetic amniocentesis.

Kong CW, Leung TN, Leung TY, Chan LW, Sahota DS, Fung TY, Lau TK

Prenatal Diag 2006;26(10): 925 - 930


Ruptured Pulmonary Arteriovenous Malformation During Pregnancy.

Wong ASW, Cheung GWY, Manlulu AV, Wan IYP, Chu MC, Yu SCH, Tam WH, Yim APC

Acta Obstet Gyn Scan 2006;85(10): 1273 - 1275


Congenital systemic Langerhans cell histiocytosis presenting as hydrops fetalis.

Lee CH, Lau TK, To KF, Lam HS, Chan AWH, Ng PC

Acta Paediatr 2005;94(12): 1843 - 1847


Detection of the placental epigenetic signature of the maspin gene in maternal plasma.

Chim SSC, Tong YK, Chiu Rossa WK, Lau TK, Leung TN, Chan LYS, Oudejans CBM, Ding CM, Lo DYM

Proc Natl Acad Sci USA 2005;102(41): 14753 - 14758


Expectation and knowledge of women undergoing first-trimester combined screening for Down syndrome in a Chinese population.

Chan LW, Chau MMC, Leung TY, Fung TY, Leung TN, Lau TK

Prenatal Diag 2005;25(13): 1248 - 1252


Fetal intra-abdominal umbilical vein varix: what is the clinical significance?

Fung TY, Leung TN, Leung TY, Lau TK

Ultrasound Obst Gyn 2005;25(2): 149 - 154


Genetic screening and diagnosis.

Lau TK, Leung TN

Curr Opin Obstet Gyn 2005;17(2): 163 - 169


Outcome of 1355 consecutive transabdominal chorionic villus samplings in 1351 patients.

Lau TK, Leung TY, Fung TY, Chan LW, Sahota DS, Leung TN

Chin Med J 2005;118(20): 1675 - 1681


Prenatal embolisation of a large chorioangioma using enbucrilate.

Lau TK, Yu SCH, Leung TY, To KF, Fung TY, Leung TN

BJOG 2005;112(7): 1002 - 1004


Reference charts of gestation-specific tissue Doppler imaging indices of systolic and diastolic functions in the normal fetal heart.

Chan Louis YS, Fok AWY, Wong JTH, Yu CM, Leung TN, Lau TK

Am Heart J 2005;150(4): 750 - 755


A validation study of ultrasonic foetal weight estimation models for Hong Kong Chinese singleton pregnancies.

Pang MW, Leung TN, Lau TK

Hong Kong Med J 2004;10(6): 384 - 388


Attitudes towards termination of pregnancy among Hong Kong Chinese women attending prenatal diagnosis counselling clinic.

Leung TN, Chau MMC, Chang JJHT, Leung TY, Fung TY, Lau TK

Prenatal Diag 2004;24(7): 546 - 551


Congenital Cervical Fibrosarcoma with Hydrops Fetalis.

Lam PM, Leung TN, Ng PC, Vlantis AC, Wong W, Lau TK

Acta Obstet Gyn Scan 2004;83(8): 773 - 776


MS analysis of single-nucleotide differences in circulating nucleic acids: Application to noninvasive prenatal diagnosis.

Ding CM, Chiu Rossa WK, Lau TK, Leung TN, Chan LC, Chan Amy YY, Charoenkwan P, Ng ISL, Law HY, Ma ESK, Xu X, Wanapirak C, Sanguansermsri T, Liao C, Tan Jin Ai MA, Chui DHK, Cantor CR, Lo DYM

Proc Natl Acad Sci USA 2004;101(29): 10762 - 10767


Treatment of twin-twin transfusion syndrome by fetoscopic laser photocoagulation.

Lau TK, Leung TY, Fung TY, Leung TN

Chin Med J 2004;117(9): 1431 - 1434


Fetus with Hydropic Change Secondary to Fetal Supraventricular Tachycardia.

Yam MC, Leung TY, Lau TK, Sung RYT

HK J Paediatr 2003;8(2): 130 - 132


Genetic alterations on chromosome 19, 20, 21, 22, and X detected by loss of heterozygosity analysis in retinoblastoma.

Huang Q, Choy KW, Cheung KF, Lam DSC, Fu WL, Pang CCP

Mol Vis 2003;9: 502 - 507


Prenatal Treatment of Chorioangioma by Microcoil Embolisation.

Lau TK, Leung TY, Yu SCH, To KF, Leung TN

BJOG 2003;110(1): 70 - 73


Prenatal exclusion of beta thalassaemia major by examination of maternal plasma.

Chiu Rossa WK, Lau TK, Leung TN, Chow KCK, Chui DHK, Lo DYM

Lancet 2002;360(9338): 998 - 1000


Second-trimester ultrasonographic assessment of the umbilical coiling index.

Qin Y, Lau TK, Rogers MS

Ultrasound Obst Gyn 2002;20(5): 458 - 463


Fetal scalp cysts: challenge in diagnosis and counseling.

Lau TK, Leung TN, Leung TY, Pang MW, Tam WH

J Ultras Med 2001;20(2): 175 - 177


Prenatal Diagnosis of Intra-abdominal Mature Testicular Teratoma.

Siu NSS, Leung TN, Leung TY, Ng SW, Yeung CK, Lau TK

J Ultras Med 2001;20(11): 1257 - 1260


Rare major maternal complications after second trimester amniocentesis: sequelae of avoiding a transplacental approach.

Lau TK, Leung TN, Leung TY, Pang MW, Tam WH

Aust NZ J Obstet Gyn 2001;41(4): 472 - 473


In Utero Treatment of Hydrops Fetalis due to Parvovirus B19 Infection: a Case Report.

Ng PS, Leung TY, Leung TN, Lau TK

HKJGOM 2000;1(1): 67 - 70


Outcome of 555 Consecutive Transabdominal Chorionic Villus Samplings in a Teaching Hospital.

Lau TK, Chau MCM, Leung TY, Pang MW, Fung TY, Leung TN

HKJGOM 2000;1(1): 21 - 27


Prenatal detection of fetal Down's syndrome from maternal plasma.

Poon LLM, Leung TN, Lau TK, Lo DYM

Lancet 2000;356(924): 1819 - 1820


Response to letter to the editor by goldwurm and biondi - "Case of congenital hypotransferrinemia suggests that tissue hypoxia during fetal development may cause hypospadias.

Fung TY

Am J Med Genet 2000;95(3): 288


Homozygous alpha-thalassemia associated with hypospadias in three survivors.

Fung TY, Lau TK, Li CK, Li CK

Am J Med Genet 1999;82(3): 225 - 227


Maternal serum screening for Down syndrome in a teaching hospital in Hong Kong.(Chinese Article)

Law LK, Lau TK, Fung TY, Rogers MS, Hjelm NM

Chin Med J 1999;112(8): 754 - 757


Rapid Clearance of Fetal DNA from Maternal Plasma.

Lo DYM, Zhang J, Leung TN, Lau TK, Chang AMZ, Hjelm NM

Am J Hum Genet 1999;64(1): 218 - 224


A study of fetal sex determination in coelomic flulid.

Lau TK, Fung TY, Wong YF, Fung HYM

Gynecol Obstet Inves 1998;45( 1): 16 - 18


In Utero Exchange Transfusion in Homozygous Alpha-Thalassaemia: A Case Report.

Fung TY, Lau TK, Tam WH, Li CK

Prenatal Diag 1998;18: 838 - 841


Maternal plasma fetal DNA as a marker for preterm labour.

Leung TN, Zhang J, Lau TK, Hjelm NM, Lo DYM

Lancet 1998;352(914): 1904 - 1905


Parvovirus B19-associated hydrops foetalis: the first confirmed case in Hong Kong.

Chan PKS, To KF, Yip SK, Tam JSL, Cheng AFB

Hong Kong Med J 1998;4(3): 321 - 323


Prenatal Diagnosis of cardiac osteoma: a case report.

Fung TY, Lau TK, Yam MC, To KF

Prenatal Diag 1998;18(11): 1209 - 1211


Quantitative analysis of fetal DNA in maternal plasma and serum: implications for noninvasive prenatal diagnosis.

Lo DYM, Tein MSC, Lau TK, Haines CJ, Leung TN, Poon PMK, Wainscoat JS, Johnson PJ, Chang AMZ, Hjelm NM

Am J Hum Genet 1998;62: 768 - 775


Racial variation in incidence of Trisomy 21: A survey of 57,742 Chinese deliveries.

Lau TK, Fung HYM, Rogers MS, Cheung KL

Am J Med Genet 1998;75(4): 386 - 388


Abdomino-amniotic shunting in isolated fetal ascites with polyhydramnios.

Fung TY, Fung HYM, Lau TK, Chang AMZ

Acta Obstet Gyn Scan 1997;76(7): 706 - 707


Crown-chin length in normal and anencephalic fetuses at 10 to 14 weeks' gestation.

Sepulveda W, Sebire NJ, Fung TY, Pipi E, Nicolaides KH

Am J Obstet Gynecol 1997;176(4): 852 - 855


Fetal bowel dilatation - Report of 3 cases with different perinatal outcomes.

Lau TK, Fung HYM, Fung TY

Aust NZ J Obstet Gyn 1997;37(3): 323 - 324


Prenatal gangrene in association with twin-twin transfusion syndrome.

Dawkins RR, Rogers MS

Am J Obstet Gynecol 1995;172(3): 1055 - 1057


Congenital listeriosis: Case reports and review of literature.

Leung TN, Cheung KL, Wong FWS

Asia Oceania J Obstet Gynaecol 1994;20(2): 173 - 177


Neural-tube defect and folic acid status in Hong Kong Chinese.

Wang VW, Chang AMZ

BJOG 1993;100: 1065


Placental bands : a variant of placenta praevia?

Stock AI, Haines CJ, Wong SP, Ghosh A

BJOG 1993;100(9): 863 - 865


Non-immune hydrops fetalis.

Li CY, Lao TTH

Asia Oceania J Obstet Gynaecol 1990;16(3): 191 - 199


The importance of early prenatal diagnosis of thanatophoric dysplasia with respect to obstetric management.

Loong EPL

Eur J Obstet Gyn R B 1987;25: 145 - 152


Racial variations in the incidence of trisomy 21.

Rogers MS

BJOG 1986;93: 597 - 599


The need for chromosome diagnosis in the third trimester of pregnancy.

Loong EPL

J Obstet Gynaecol 1986;6: 215


The use of a microcomputer in the antenatal interview - a feasibility study.

Wong FWS

HK Pract 1986;8: 1650 - 1656


Ultrasound diagnosis of recurrence of Majewski Dwarfism.

Rogers MS, Cruickshank J

J.HK.Med.Assn. 1985;37: 95 - 97