Dr. Zhang Tao, Judy Research Assistant Professor
(852) 3505 1289 taozhang@cuhk.edu.hk

Biography

Dr. Zhang is an expert in the field of reproductive immunology, with research focused on bridging the gap between basic laboratory findings and clinical applications. She has recently concentrated her efforts on understanding and evaluating endometrial receptivity from an immunological perspective, particularly in women wtih repeated implantation failure, recurrent miscarriage, adenomyosis, and endometriosis. Her innovative research aims to identify novel diagnostic markers and therapeutic targets for precision treatments designed to improve endometrial receptivity and enhance pregnancy outcomes for women affected by these conditions. Through her work, Dr. Zhang is making significant contributions to advancing fertility treatments and improving women's reproductive health.

Dr. Zhang has authored 80 publications in international peer-reviewed journals and contributed to 14 books. Her outstanding work has been featured in prestigious journals, including Science Advances, Advanced Science, Autophagy, Immunological Reviews, Theranostics, BMC Biology, Journal of Autoimmunity, The EMBO Journal, and Fertility and Sterility, among others, garnering over 1,900 citations and an H-index of 24. Her research projects have received support from competitive external grants, including those from the National Natural Science Foundation of China, Health and Medicine Research Funding, Shenzhen Science Project Funding, and the Hong Kong Obstetrics and Gynaecology Trust Fund.

In addition to her research, Dr. Zhang has served as an editorial member for the American Journal of Reproductive Immunology for over six years and is an active member of academic societies such as the American Society of Reproductive Immunology, Asia Pacific Initiative on Reproduction Society, and the International Society of Reproductive Immunology, playing a key role in advancing scholarly discourse in her field.

Education

PhD in Genetics, Department of Obstetrics and Gynacology, The Chinese University of Hong Kong

Research Interest(s)

  • Development of novel immune tests to assess endometrial receptivity. One of my research projects focuses on developing laboratory tests to evaluate the endometrial immunomicroenvironment, which will assist clinicians in managing patients undergoing IVF-ET treatments.
  • Development of peripheral markers to predict early miscarriage: investigating the longitudinal changes of peripheral immune markers during early pregnancy to develop predictive screening methods for early miscarriage.
  • Development of precision treatments targeting endometrial and peripheral immune markers: exploring the causal effects of these markers and developing targeted therapies that enhance successful implantation and maintain pregnancy.

Specialisations

  • Recurrent miscarriage and infertility
  • Endometriosis and adenomyosis
  • Immunology

Qualifications

MB.BS., M.Med. (O&G), Ph.D. (O&G)

Awards and Honours

  • Third Price, Science and Technology Award for Maternal and Child Health, Chinese Association of Maternal and Child Health, China, 2025
  • Silicon Valley International Invention Festival, Gold Medal, 2024
  • Geneva Inventions, Silver Medal, 2024
  • International Invention Fair in the Middle East, Silver Medal, 2024
  • Hong Kong Jockey Club Fellowship, ACU Fellowship, 2024
  • ACU Early Career Conference Grants, 2023
  • Travel Award, The American Society of Reproductive Immunology, 2023
  • International Invention Fair in the Middle East, Silver Medal, 2023
  • Geneva Inventions, Silver Medal, 2022
  • American Journal of Reproductive Immunology Top Reviewer, 2018
  • First prize, Shenzhen Science and Technology program, 2016

Others

2024-present core member, CUHK - Sichuan University Joint Laboratory in Reproductive Medicine, CUHK

2021-present 副研究员, 香港中文大学深圳研究院, 深圳

Business Leadership

2024 -present, Chief Technology Officer, GynaeSolution Ltd, Hong Kong.

Researcher ID

1
Impact of Day-3 embryo cell number on pregnancy, obstetric and perinatal outcomes in frozen-thawed single blastocyst transfer cycles Xiong F, Wan C, Peng X, Sun Q, Xu S, Diao L, Chen P, Zhong H, Mo M*, Zhang T* Frontiers in Endocrinology, 2026 Jun;17:1777070
2
Recent Advances in Multimodal Approaches for Investigating Placental Development and Related Diseases Wang H, Zhang T, Ruan J, Zheng X, Zheng S, Liu Q, He F, Sun B, Zhang Q, Zhu Y, Chen X Placenta, 2026 Jun;180:19-25
3
PFAS exposure and reproductive dysfunction: implications for outcomes in assisted reproductive technologies Shu X, Zhou WJ, Zhang T, Ye JF, Zhao YJ, Gu CJ, Yu YY, Li MQ Frontiers in Endocrinology, May 2026;17 - 2026:1808266
4
Multi-target modulation of the homologous recombination pathway by resveratrol promotes DNA damage repair in POI: integrated network pharmacology, molecular dynamics simulation, and experimental validation Yu Z, Peng W, Li M, Li F, Zhang T, Nong Y, Liu C, Liu W, Ding H, Lv X, Wang J, Zhang X, Liu F, Wu H International Journal of Surgery, 2026 Apr;112(4):9404-9426
5
Characterization of endometrial immune cells during the window of implantation in infertile women with adenomyosis Yu S, Geng Q, Liu Z, Wu Y, You G, Li Y, Zhang T* Journal of Reproductive Immunology, 2026 Mar;174:104854
6
ICG-001 Provides Cardioprotection Against Doxorubicin-Induced Cardiotoxicity and Enhances Cancer Cytotoxicity Wu B, Chen JCH, Ma CHY, Kwok M, Chan VT, Sung CC, Song Y, Zhang T, Lam H S, Meng F, Liang Y, Tsoi C, Deng R, Tsui SKW, Leung KT, Wang CC, Chan GCF, Boheler KR, Chung KKK, Poon EN JACC: Basic to Translational Science, 2026 Feb;11(2):101459
7
Oxidative Stress Mediated by Macrophages Promotes Angiogenesis and Early Development of Endometriosis Gene Chi Wai Man, Astrid Borchert, Tao Zhang, Sze Wan Hung, Hartmut Kühn, Chi Chiu Wang Antioxidants, 2026 Jan;15(2):159
8
Integrated omics and machine learning uncover the molecular basis of environmental toxicant 6PPD-Qinduced non-obstructive azoospermia Jiang X, Lu H, Ou G, Zhang T, Xie L, Zhou J, Hou W, Xu Q, Hu W, Zou W, Cao Y Ecotoxicology and Environmental Safety, 2026 Jan;310:119794
9
Polystyrene nanoplastics induce ovarian granulosa cell senescence via autophagy suppression Hu H, Ouyang H, Ma L, Xu Q, Peng Y, Meng M, Zhang T* NanoImpact, 2026 Jan;41:100607
10
Lnc-HZ14 promotes LLPS-mediated SPHK1 aggrephagy degradation to suppress trophoblast cell proliferation in unexplained recurrent miscarriage Wang R, Sun Y, Zhao J, Xu Z, Wei Q, Zhang T, Lin Y, Guo G, Li X, Huang W, Qian J, Xing S, Wang M, Qi M, Zhang H Autophagy, 2025 Dec;21(12):3195-3215
11
ASRI Guidelines on Recurrent Pregnancy Loss: Addressing Concerns and Reinforcing Evidence-Based, Specialized Care Cavalcante, MB, Harrity C, Luu, T, Fatunbi J, Nakagawa K, Zhang Y, Zhang T, Alanazi H, Wu L, Lee S, Barini R, Kwak-Kim J American Journal of Reproductive Immunology, 2025 Oct;94(4):e70173
12
Distinct Suppression of Prednisone on Endometrial Immune Cells in Women with Reproductive Failure Chen L, Chen X, Xu Q, Li JXJ, Yang WJ, Wu H, Wang CC, Fan X, Ji J, Chung PWJ, Li M, Li TC, Zhang T American Journal of Reproductive Immunology, 2025 Oct;94(4):e70151
13
Lnc-HZ05 Suppresses Trophoblast Cell Migrasome Formation by Disrupting TGFβ2 Pathway in Unexplained Recurrent Miscarriage Chen W, Zhang Y, Zhao Z, Yang Y, Guo G, Sun Y, Zhang T, Zhang Z, Zeng L, Huang W, Shen Q, Han R, He Z, Zhao D, Zhang H Advanced Science, Oct 2025 13(2) e17558
14
Single-cell RNA sequencing of endometrium uncovers dynamic characteristics and dysregulation of perivascular CD9+SUSD2+ cells in thin endometrium Liang B, Qi L, Chen M, Mai C, Diao L, Ding L, Zhang T, Chen X Stem Cell Research and Therapy, 2025 Sep;16(1):515
15
Melatonin Protects against LPS-Induced Mitochondrial Dyshomeostasis and Ovarian Damage through JNK Signaling Pathway in Mouse Ovary Shi LG, Ding SM, Guo TK, Chen P, Cui SS, Yang ZN, Wang M, Wang R, Ji D, Zhang T, Liang D, Wang L, Cao Y, Liu Y Reproductive Sciences, 2025 Aug 12 ;32(9):3154–3165
16
PGK1 Regulates Oxidative Stress in Gestational Diabetes Mellitus through the Estradiol-Keap1-Nrf2 Pathway Peng Y, Zhao H, Chen, J, Wang CC, Zhang T, Yeung TC, Ouyang H, Zhu J, Chen X, Li M, Hu H, Zhong M International Journal of Biological Sciences, 2025 Aug;21(12):5496-5513
17
PGK1 Regulates Oxidative Stress in Gestational Diabetes Mellitus through the Estradiol-Keap1-Nrf2 Pathway Peng Y, Zhao H, Chen, J, Wang CC, Zhang T, Yeung TC, Ouyang H, Zhu J, Chen X, Li M, Hu H, Zhong M International Journal of Biological Sciences, 2025 Aug;21(12):5496-5513
18
Book Title: International Review of Cell and Molecular Biology, Volume: γδ ⊤ Cells in Health and Disease - Part A
Chapter Title: Chapter Five - Gamma delta T cells: Multifaceted mediators in pregnancy and the pathogenesis of miscarriage
Xu Q, Chen L, DAI J, Chung JPW, Wang CC, Liao A, Zhang T Elsevier Inc 2025;397:105-152
19
Book title: Cancer Treatment Modalities: An Interdisciplinary Approach
Chapter Title: The Interplay of ferroptosis and cuproptosis in cancer: Mechanisms and therapeutic implications
Wang J, Chan KYL, Zhang T, Li J, Liu J, Lau TS, Wang CC Rezaei, N (ed) 1 ed Springer , 2025 Vol 24 p 295-332 38 p (Interdisciplinary Cancer Research)
20
2025 American Society for Reproductive Immunology Guidelines for the Treatment of Recurrent Pregnancy Losses: Practice Recommendations From the ASRI Clinical Reproductive Immunology Fellowship Cavalcante MB, Harrity C, Luu T, Fatunbi J, Nakagawa, K, Zhang Y, Zhang T, Alanazi H, Wu L, Lee S, Barini R, Kwak-Kim J American Journal of Reproductive Immunology, 2025 Jun;93(6):e70099
21
Measurement of four novel endometrial NK cell subsets by multiplex staining in women with reproductive failure: A comparison with fertile controls Chen L, Yang WJ, Chen X, Li JJX, Xu Q, Chen J, Wang CC, Chung PWJ, Li M, Li TC, Zhang T Journal of Reproductive Immunology, 2025 Jun:169:104525
22
Pregnancy characteristics of patients with systemic lupus erythematosus with different onset times and their risk of adverse pregnancy outcomes: A retrospective cohort study Xu Y, Deng X, Zhang T, Zhang M, Huo J, Peng Y, Yin Q, Liu S, Ouyang H, Ma L, Liu R, Chen J, Xie R, Hu G, Hu H, Zhong M Lupus Science and Medicine, 2025 Jun;12(1):e001529
23
Gut microbiota-driven pathogenic Th17 cells mediated autoimmune epididymo-orchitis in a mouse model of colitis Zeng Q, Liu JC, Yang C, Lyu M, Li D, Yeung W S B, Chiu PCN, Zhang T, Duan YG iScience, May 2025;28(5):112508
24
Intrauterine infusion of autologous platelet-rich plasma modulates endometrial immune status and improves pregnancy outcomes in patients with persistent chronic endometritis Chen X, Chen M, Liu M, Qi L, Liu Z, Chen C, Liang B, Yang X, Zhang T, Li Y, Lian R Frontiers in Immunology, 2025 May 15;16:1528522
25
Neutrophil extracellular traps induce trophoblasts pyroptosis via enhancing NLRP3 lactylation in SLE pregnancies Hu H, Peng Y, Wang CC, Chen J, Yu X, Chen X, Ouyang H, Huang Q, Ma J, Yin Q, Ma L, Ding Z, Zhang M, Ren H, Zheng J, Chen W, Tao Z, Liu R, Chen L, Wang X, Zhang T, Zhong M Journal of Autoimmunity. 2025 May;153(2025):103411
26
Association Between Exposure to Multiple Toxic Metals in Follicular Fluid and the Risk of PCOS Among Infertile Women: The Mediating Effect of Metabolic Markers Wang X, Zhang Y, Peng J, Zhang H, Jiang T, Zhang Z, Yin T, Su X, Zhang T, Shen L, He S, Wang X, Li D, Yue X, Ji D, Zhang D, Dong R, Zou W, Liang D, Liu Y, Du Y, Zhang Z, Cao Y, Liang C, Ji D Biol Trace Elem Res. 2025 Feb;203(2):775-789
27
Perturbations of the endometrial immune microenvironment in endometriosis and adenomyosis: their impact on reproduction and pregnancy Shi J, Xu Q, Yu S, Zhang Tao Seminars in Immunopathology 2025 Feb;47(16):16
28
人工智慧在胚胎形態學評估中的應用現狀、局限性與技術瓶頸 Zhao M, Liu J, Zhang T Chinese Journal of Reproduction and Contraception. 2025 Feb;45(2):135-141
29
Melatonin Inhibits Endometriosis Growth via Specific Binding and Inhibition of EGFR Phosphorylation Li YR, Hung SW, Zheng X, Ding Y, Zhang T, Tan Z, Zhang R, Lin YZ, Song Y, Wang Y, Wang CC J Pineal Res. 2024 Nov;76(8):e70022
30
TNFSF14+ natural killer cells prevent spontaneousabortion by restricting leucine-mediated decidual stromal cell senescence Shi Jia-Wei, Lai Zhen-Zhen, Zhou Wen-Jie, Yang Hui-Li, Zhang Tao, Sun Jian-Song, Zhao Jian-Yuan, Li Ming-Qing EMBO J. 2024 Nov;43(21):5018-5036
31
Measurement of Four Uterine NK Cell Subtypes Using Multiplexed Fluorescent Immunohistochemical Staining in Women with Repeated Implantation Failure Chen L, Chan LKY, Wong SCY, Li JJX, Chung JPW, Wang CC, Li M, Zhang T J Vis Exp. 2024 Oct 25:(212) e67284
32
Unique anti-angiogenic effects, pharmacological targets and therapeutic mechanisms of Chinese herbal medicines for endometriosis Liang B, Dong R, Hung SW, Li YR, Lin YZ, Wu L, Zhang T, Man GCW, Xu H, Chung JPW, Wang CC Genes & Diseases. 2024 Sep;11(5):101166.
33
Proteomics approach to discovering non-invasive diagnostic biomarkers and understanding the pathogenesis of endometriosis: a systematic review and meta-analysis Azeze GG, Wu L, Alemu BK, Lee WF, Fung LWY, Cheung ECW, Zhang T, Wang CC J Transl Med. 2024 Jul 26;22(1):685
34
Thrombospondin-1 regulates trophoblast necroptosis via NEDD4-mediated ubiquitination of TAK1 in preeclampsia Hu HY, Ma J, Peng Y, Feng RX, Luo CL, Zhang MY, Tao ZX, Chen L, Zhang T, Chen WQ, Yin Q, Zhai JG, Chen J, Yin AL, Wang CC, Zhong M Adv Sci (Weinh). 2024 Jun;11(21):e2309002
35
Changes in the number and activity of Natural killer cells and its clinical association with endometriosis: systematic review and meta-analysis Azeze GG, Wu L, Alemu BK, Wang CC, Zhang T F & S Review. 2024 Apr;5(2):100072
36
Isolation of myeloid-derived suppressor cells (MDSC) from endometriotic mice model and their immunomodulatory functions Song Y, Liu Y, Xu Q, Leung KT, Chan LKY, Chung JPW, Wang CC, Chen X, Zhang T, Man GCW Methods Cell Biol. 2024:184:33-57
37
Antiviral Effects and Mechanisms of Green Tea Catechins on Influenza: A Perception on Combating Symptoms from COVID-19 Man GCW, Zheng X, Hung SW, Chan LKY, Zhang T, Chen X, Chu KO, Huen ICY, Lui DWY, Wong AD, Wang CC Curr Top Med Chem. 2024;24(1):60-73
38
Distinct molecular targets of ProEGCG from EGCG and superior inhibition of angiogenesis signaling pathways for treatment of endometriosis Hung SW, Gaetani M, Li Y, Tan Z, Zheng X, Zhang R, Ding Y, Man GCW, Zhang T, Song Y, Wang Y, Chung JPW, Chan TH, Zubarev RA, Wang CC Journal of Pharmaceutical Analysis 2024 Jan;14(1):100-114
39
Decreased serum soluble programmed cell death ligand-1 level as a potential biomarker for missed miscarriage Li Q, Chen C, Wu J, Poon LC, Wang CC, Li TC, Zhang T, Guo X, Song L, Wang X, Zhang Q, Ye Z, Yang Y, Lu J, Yao J, Ye D, Wang Y Hum Reprod. 2023 Nov 2;38(11):2128-2136  
40
Recent Advances in Folates and Autoantibodies against Folate Receptors in Early Pregnancy and Miscarriage  Qin XY, Ha SY, Chen L, Zhang T, Li MQ Nutrients. 2023 Nov;15(23):4882 
41
Association of angiotensin II and receptors in peri-implantation endometrium with microvessel density and pregnancy outcomes of women with recurrent implantation failure after embryo transfer Qi R, Zhang T, Zhang YY, Chung JPW, Yang W, Wang CC Front Endocrinol (Lausanne). 2023 Aug 29:14:1206326
42
Identification of potential biomarkers and immune infiltration characteristics in recurrent implantation failure using bioinformatics analysis Lai ZZ, Zhang J, Zhou WJ, Shi JW, Yang HL, Yang SL, Wu JN, Xie F, Zhang T, Li MQ Front Immunol. 2023 Jan 26;14:992765
43
Diminished Ovarian Reserve in Endometriosis: Insights from In Vitro, In Vivo, and Human Studies—A Systematic Review Tan Z, Gong X, Wang CC, Zhang T, Huang J Int. J. Mol. Sci. 2023, 24(21), 15967
44
Myeloid-derived suppressor cells: A new emerging player in endometriosis Zhang T, He Y, Man GCW, Ding Y, Wang CC, Chung JPW Int Rev Cell Mol Biol. 2023;375:191-220
45
An IGF1-expressing endometrial stromal cell population is associated with human decidualization Shi JW, Lai ZZ, Yang HL, Zhou WJ, Zhao XY, Xie F, Liu SP, Chen WD, Zhang T, Ye JF, Zhou XY, Li MQ BMC Biol. 2022 Dec 8;20(1):276
46
A prospective study comparing the inflammation-related cytokine and chemokine profile from the day of blastocyst transfer to 7 weeks of gestation between pregnancies that did or did not result in a miscarriage Zhao Y, Man GCW, Zhang R, Wong CK, Chen X, Chung JP, Wang CC, Laird S, Zhang T, Li TC J Reprod Immunol. 2022 Dec;154:103755
47
Pharmacogenomic Profiling of Pediatric Acute Myeloid Leukemia to Identify Therapeutic Vulnerabilities and Inform Functional Precision Medicine Wang H, Chan KYY, Cheng CK, Ng MHL, Lee PY, Cheng FWT, Lam GKS, Chow TW, Ha SY, Chiang AKS, Leung WH, Leung AYH, Wang CC, Zhang T, Zhang XB, So CC, Yuen YP, Sun Q, Zhang C, Xu Y, Cheung JTK, Ng WH, Tang PM, Kang W, To KF, Lee WYW, Wong RSM, Poon ENY, Zhao Q, Huang J, Chen C, Yuen PMP, Li CK, Leung AWK, Leung KT Blood Cancer Discov. 2022 Nov 2;3(6):516-535
48
Pharmacogenomic profiling of pediatric acute myeloid leukemia to identify therapeutic vulnerabilities and inform functional precision medicine. Wang H, Chan KYY, Cheng CK, Ng MHL, Lee PY, Cheng FWT, Lam GKS, Chow TW, Ha SY, Chiang AKS, Leung WH, Leung AYH, Wang CC, Zhang T, Zhang XB, So CC, Yuen YP, Sun QW, Zhang C, Xu YQ, Cheng JTK, Ng WH, Tang PMK, Kang W, To KF, Lee WYW, Wong RS, Poon ENY, Zhao Q, Huang JB, Chen C, Yuen PMP, Li CK, Leung AWK, Leung KT. Blood Cancer Discov. 2022 Nov 2;3(6):516-535.
49
Pathogenic mitochondrial DNA 3243A>G mutation: From genetics to phenotype. Li DY, Liang CM, Zhang T, Marley JL, Zou WW, Lian MQ, Ji DM. Front Genet. 2022 Oct 6;13:951185
50
A defective lysophosphatidic acid-autophagy axis increases miscarriage risk by restricting decidual macrophage residence Yang HL, Lai ZZ, Shi JW, Zhou WJ, Mei J, Ye JF, Zhang T, Wang J, Zhao JY, Li DJ, Li MQ Autophagy. 2022 Oct;18(10):2459-2480
51
Dynamic changes in maternal immune biomarkers during labor in nulliparous versus multiparous women Ding W, Lau SL, Wang CC, Zhang T, Getsko O, Lee NMW, Chim SSC, Wong CK, Leung TY Am J Obstet Gynecol. 2022 Oct;227(4):627.e1-627.e23
52
Melatonin in Endometriosis: Mechanistic Understanding and Clinical Insight Li Y, Hung SW, Zhang R, Man GCW, Zhang T, Chung JPW, Fang L, Wang CC Nutrients. 2022 Oct; 14(19):4087
53
What we have learned from animal models to understand the etiology and pathology of endometrioma-related infertility. Tan ZYR, Hung SW, Zheng X, Wang CC, Chung JPW, Zhang T Biomedicines. 2022, 10(7), 1483
54
Single-cell transcriptome profiling of the human endometrium of patients with recurrent implantation failure Lai ZZ, Wang Y, Zhou WJ, Liang Z, Shi JW, Yang HL, Xie F, Chen WD, Zhu R, Zhang C, Mei J, Zhao JY, Ye JF, Zhang T, Li MQ Theranostics Sep 2022; 12(15): 6527-6547
55
Systematic review update and meta-analysis of randomized and non-randomized controlled trials of ovarian stimulation versus artifcial cycle for endometrial preparation prior to frozen embryo transfer in women with polycystic ovary syndrome Zhang YY, Wu L, Li TC, Wang CC, Zhang T, Chung PWJ Reprod Biol Endocrinol. 2022 Apr 2;20(1):62
56
Immunologic Memory in Pregnancy: Focusing on Memory Regulatory T Cells Zhang YJ, She L, Zhang T, Muyayalo KP., Luo J, Mor G, Liao AH Int. J. Biol. Sci. 2022 Mar; 18(6): 2406-2418
57
A defective lysophosphatidic acid-autophagy axis increases miscarriage risk by restricing decidual macrophage residence. Yang HL, Lai ZZ, Shi JW, Zhou WJ, Mei J, Ye JF, Zhang T, Wang J, Zhao JY, Li DJ, Li MQ. Autophagy 2022 Feb 27;1-22
58
Fructose-1,6-bisphosphate prevents pregnancy loss by inducing decidual COX-2+ macrophage differentiation Zhou WJ, Yang HL, Mei J, Chang KK, Lu H, Lai ZZ, Shi JW, Wang XH, Wu K, Zhang T, Wang J, Sun JS, Ye JF, Li DJ, Zhao JY, Jin LP, Li MQ Sci Adv. 2022 Feb 25;8(8):eabj2488.
59
Serial changes in two immune checkpoint receptors and ligands, Tim-3/Gal-9 and PD-1/PD-L1 in peripheral blood prior to miscarriage: Comparison with pregnancies resulting in a live birth Zhang T, Zhao YW, Cheung WC, Gan YH, Huang L, Li MQ, Leung KT, Chung PW, Wang CC, Laird S, Chen XY, Li TC Am J Reprod Immunol. 2022 Feb 7;e13524
60
Insight of autophagy in spontaneous miscarriage. Qin XY, Shen HH, Zhou WJ, Mei J, Lu H, Tan XF, Zhu R, Zhou WH, Li DJ, Zhang T, Ye JF, Li MQ. Int J Biol Sci. 2022 Jan 1; 18(3): 1150-1170
61
Auto-immunity and endometriosis: evidence, mechanism and therapeutic potential Zhang T, Li TC, Wang CC In: Immunology of Endometriosis: Pathogenesis and Management
62
Biol Reprod. Metabolic markers of biological fluid in women with reproductive failure: a systematic review of current literature. Zhang YY, Zhang T, Wu L, Li TC, Wang CC, Chung JPW. Biol Reprod 2022, 106(6): 1049-1058
63
Efficacy and safety of Chinese herbal medicine for endometriosis associated pain. Lin YZ, Hou RJ, Zhang T, Chung JPW, Wang CC, RH Zhao. The American Journal of Chinese Medicine 2022, 50(4): 1095-1111
64
The metabolic characteristic of decidual immune cells and its unique properties in pregnancy loss. Zhang T, Shen HH, Qin XY, Li MQ. Immunological Reviews. 2022. 308 (1):168-186
65
The identification of endometrial immune cell densities and clustering analysis in the mid-luteal phase as predictor for pregnancy outcomes after IVF-ET treatment Zhao Y, Man GCW, Wang J, Liu Y, Kwong J, Zhang T, Chung JPW, Wang CC, Chen X, Li TC J Reprod Immunol. 2021 Oct 5;148:103431
66
Therapeutic effects of green tea on endometriosis. Chen X, Man GCW, Hung SW, Zhang T, Fung LWY, Cheung CW, Chung JPW, Li TC, Wang CC. Crit Rev Food Sci Nutr. 2021 Oct 7:1-14
67
Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage Zhao Y, Man GCW, Chan LKY, Guo X, Liu Y, Zhang T, Kwong J, Wang CC, Chen X, Li TC J Vis Exp. 2021 Aug 4;(174): e62931
68
Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review Hung SW, Zhang RZ, Tan ZYR, Chung JPW, Zhang T, Wang CC Med Res Rev. 2021 Jul;41(4):2489-2564
69
Receptor tyrosine kinase inhibitor Sunitinib as novel immunotherapy to inhibit myeloid-derived suppressor cells for treatment of endometriosis He Y, Hung SW, Liang B, Zhang RZ, Gao YT, Chu CY, Xu H, Zhang T, Chung JPW, Wang CC Front. Immunol. 2021 July;12:641206
70
Protopanaxadiol improves endometriosis associated infertility and miscarriage in sex hormones receptors-dependent and independent manners Lai ZZ, Yang HL, Shi JW, Shen HH, Wang Y, Chang KK, Zhang T, Ye JF, Sun JS, Qiu XM, Li MQ Int J Biol Sci. 2021 May 5;17(8):1878-1894
71
Protopanaxadiol improves endometriosis associated infertility and miscarriage in sex hormones receptors-dependent and independent manners. Lai ZZ, Yang HL, Shi JW, Shen HH, Wang Y, Chang KK, Zhang T, Ye JF, Sun JS, Qiu XM, Li MQ. Int J Biol Sci. 2021 May 5;17(8):1878-1894
72
Successful implantation is associated with a transient increase in serum pro-inflammatory cytokine profile, following by a switch to anti-inflammatory cytokine profile prior to confirmation of pregnancy Zhao Y, Zhang T, Guo X, Wong CK, Chen X, Chan YL, Wang CC, Laird S, Li TC Fertil Steril. 2021 Apr;115(4):1044-1053
73
Successful implantation is associated with a transient increase in serum pro-inflammatory cytokine profile, following by a switch to anti-inflammatory cytokine profile prior to confirmation of pregnancy. Zhao Y, Zhang T, Guo X, Wong CK, Chen X, Chan YL, Wang CC, Laird S, Li TC. Fertil Steril. 2021 Apr; 115(4):1044-1053
74
Uterine CD56+ cell density and euploid miscarriage in women with a history of recurrent miscarriage: A clinical descriptive study Chen X, Zhang T, Liu Y, Cheung WC, Zhao Y, Wang CC, Laird S, Li TC Eur J Immunol. 2021 Feb;51(2):487-489
75
Auto-immunity and endometriosis: evidence, mechanism and therapeutic potential. In: Immunology of Endometriosis: Pathogenesis and Management (2021) Zhang T, Li TC, Wang CC. Volume 2 Chapter 6:85-104
76
Ovarian hormones-autophagy-immunity axis in menstruation and endometriosis. Shen HH, Zhang T, Yang HL, Lai ZZ, Zhou WJ, Mei J, Shi JW, Zhu R, Xu FY, Li DJ, Ye JF, Li MQ. Theranostics. 2021; 11(7): 3512-3526.
77
Autoimmunity and infertility. Translational Immunology (2021) Zhang T, Chen XY, Li TC, Wang CC, Chung JPW. Volume 3 Autoimmune Disease Associated with Different Clinical Features Chapter 9:185-206
78
Early transient suppression of immune checkpoint proteins T-cell immunoglobulin mucin-3 and programmed cell death-1 in peripheral blood lymphocytes after blastocyst transfer is associated with successful implantation Zhang T, Zhu W, Zhao Y, Cheung WC, Liu Y, Chen X, Du Y, Leung KT, Chan YL, Wang CC, Laird S, Li TC Fertil Steril. 2020 Aug;114(2):426-435
79
Effects of high progesterone in in-vitro fertilization cycle on DNA methylation and gene expression of adhesion molecules on endometrium during implantation window Xiong Y, Hu L, Zhang T, Wang M, Xu H, Li TC, Sun Y, Wang CC J Assist Reprod Genet. 2020 Jan;37(1):33-43
80
Early transient suppression of immune checkpoint proteins Tim-3 and PD-1 in peripheral blood lymphocytes after blastocyst transfer is associated with successful implantation. Zhang T, Zhu WY, Zhao YW, Cheung WC, Liu YY, Chen XY, Du Y, Leung KT, Chan YL, Wang CC, Laird S, Li TC. Fertility and Sterility. 2020 Aug;114(2):426-435.
81
The use of multiplex staining to measure the density and clustering of four endometrial immune cells around the implantation period in women with recurrent miscarriage: comparison with fertile controls Zhao Y, Chen X, Zhang T, Chan LKY, Liu Y, Chung JP, Kwong J, Li TC Journal of Molecular Histology. 2020, Aug; 51: 593-603.
82
Association between chronic endometritis and uterine natural killer cell density in women with recurrent miscarriage: clinical implications. Chen XY, Liu YY, Zhao YW, Cheung WC, Zhang T, Qi RF, Chung JPW, Wang CC, Li TC. Journal of Obstetrics and Gynaecology Research. 2020 Jun; 46(6): 858-863.
83
Effects of high progesterone in in-vitro fertilization cycle on DNA methylation and gene expression of adhesion molecules on endometrium during implantation window. Xiong Y, Hu L, Zhang T, Wang M, Xu H, Li TC, Sun Y, Wang CC. Journal of Assisted Reproduction and Genetics. 2020 Jan;37(1):33-43.
84
Intrauterine infusion of human chorionic gonadotropin before embryo transfer in IVF/ET cycle: the critical review. Zhang T, Chen XY, Wang CC, Li TC, Kwak-Kim J. American Journal of Reproductive Immunology. 2019 Feb; 81(2): e13077.
85
Tradition al and molecular chromosomal abnormality analysis of products of conception in spontaneous and recurrent miscarriage Zhang T, Sun Y, Chen Z, Li TC BJOG. 2018 Mar;125(4):414-420
86
The link between immunity, autoimmunity and endometriosis: a literature update. Zhang T, Carolis CD, Man GCW, Wang CC#. Autoimmunity reviews. 2018 Oct;17(10):945-955.
87
The link between immunity, autoimmunity and endometriosis: a literature update Zhang T, De Carolis C, Man GCW, Wang CC Autoimmun Rev 2018 Oct 17 (10) 945-955
88
MDSCs drive the process of endometriosis by enhancing angiogenesis and provide a new potential approach for treatment. Zhang T, Zhou JH, Man GCW, Leung KT, Liang B, Xiao B, Ma XT, Huang SY, Huang HX, Hegde VL, Zhong Y, Li YM, Kong GWS, Yiu AKW, Kwong J, Ng PC, Lessey BA, Nagarkatti PS, Nagarkatti M, Wang CC. European Journal of Immunology. 2018 Jun; 48(6):1059-1073.
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Intrauterine infusion of human chorionic gonadotropin before embryo transfer in IVF/ET cycle: The critical review Zhang T, Chen X, Wang CC, Li TC, Kwak KJ Am J Reprod Immunol. 2018 Dec 27:e13077, 12 pages
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MDSCs drive the process of endometriosis by enhancing angiogenesis and provide a new potential approach for treatment. Zhang T, Zhou JH, Man GCW, Leung KT, Liang B, Xiao B, Ma XT, Huang SY, Huang HX, Hegde VL, Zhong Y, Li YM, Kong GWS, Yiu AKW, Kwong J, Ng PC, Lessey BA, Nagarkatti PS, Nagarkatti M, Wang CC. Eur J Immunol. 2018 Jun; 48(6): 1059-1073.
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Detection of dendritic cells and related cytokines in follicular fluid of patients with polycystic ovary syndrome. Zhang T, Tian F, Huo R, Tang A, Zeng Y, Duan YG. Am J Reprod Immunol. 2017 Sep; 78(3): e12717.
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Efficacy of intrauterine perfusion of granulocyte colony-stimulating factor (G-CSF) for infertile women with thin endometrium: A systematic review and meta-analysis. Xie YR, Zhang T, Tian ZP, Zhang JM, Wang WX, Zhang H, Zeng Y, Ou JP, Yang YH. Am J Reprod Immunol. 2017 Aug; 78(2): e12701.
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The regulations and role of circadian clock and melatonin in uterine receptivity and pregnancy—An immunological perspective Man GCW, Zhang T, Chen X, Wang J, Wu F, Liu Y, Wang CC, Cheong Y, Li TC Am J Reprod Immunol. 2017 Aug;78(2)e12715
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Human chorionic gonadotropin potentially affects pregnancy outcome in women with recurrent implantation failure by regulating the homing preference of regulatory cells. Diao LH, Li GG, Zhu YC, Tu WW, Huang CY, Lian RC, Chen X, Li YY, Zhang T, Huang Y, Zeng Y. Am J Reprod Immunol. 2017 Mar; 77(3): e12618.
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Successful treatment with intrauterine delivery of dexamethasone for repeated implantation failure. Zhang T, Huang CY, Du Y, Lian RC, Mo ML, Zeng Y, Mor G. American Journal of Reproductive Immunology. 2017 Dec;78(6): e12766.
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Successful treatment with intrauterine delivery of dexamethasone for repeated implantation failure. Zhang T, Huang CY, Du Y, Lian RC, Mo ML, Zeng Y, Mor G. Am J Reprod Immunol. 2017 Dec; 78(6): e12766.
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Detection of dendritic cells and related cytokines in follicular fluid of patients with polycystic ovary syndrome. Zhang T, Tian F, Huo R, Tang A, Zeng Y, Duan YG. American Journal of Reproductive Immunology. 2017 Sep; 78(3): e12717.
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Efficacy of intrauterine perfusion of granulocyte colony-stimulating factor (G-CSF) for infertile women with thin endometrium: A systematic review and meta-analysis. Xie YR, Zhang T, Tian ZP, Zhang JM, Wang WX, Zhang H, Zeng Y, Ou JP, Yang YH. American Journal of Reproductive Immunology. 2017 Aug; 78(2): e12701.
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The regulations and role of circadian clock and melatonin in uterine receptivity and pregnancy-An immunological perspective. Man GCW, Zhang T, Chen X, Wang J, Wu F, Liu Y, Wang CC, Cheong Y, Li TC. American Journal of Reproductive Immunology. 2017 Aug; 78(2): e12715.
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Human chorionic gonadotropin potentially affects pregnancy outcome in women with recurrent implantation failure by regulating the homing preference of regulatory cells. Diao LH, Li GG, Zhu YC, Tu WW, Huang CY, Lian RC, Chen X, Li YY, Zhang T, Huang CY, Zeng Y. American Journal of Reproductive Immunology. 2017 Mar; 77(3): e12618.
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Modulatory effects of vitamin D on peripheral cellular immunity in patients with recurrent miscarriage. Chen X, Yin B, Lian RC, Zhang T, Zhang HZ, Diao LH, Li YY, Huang CY, Liang DS, Zeng Y. Am J Reprod Immunol. 2016, 76(6): 432-438
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Modulatory effects of vitamin D on peripheral cellular immunity in patients with recurrent miscarriage. Chen X, Yin B, Lian RC, Zhang T, Zhang HZ, Diao LH, Li YY, Huang CY, Liang DS, Zeng Y. Am J Reprod Immunol. 2016 Dec, 76(6): 432-438.
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Prodrug of green tea epigallocatchin-3-gallate (Pro-EGCG) as a potent anti-angiogenesis agent for endometriosis in mice. Wang CC, Xu H, Man GCW, Zhang T, Chu KO, Chu CY, Cheng JT, Li G, He YX, Qin L, Lau TS, Kwong J, Chan TH. Angiogenesis 2013 Aug; 16(1): 59-69.
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Vascular endothelial growth factor C is increased in endometrium and promotes endothelial functions, vascular permeability and angiogenesis and growth of endometriosis. Xu H, Zhang T, Man GCW, May KE, Becker CM, Davis TN, Kung AL, Birsner AE, D’Amato RJ, Wong AW, Wang CC. Angiogenesis 2013 Jul; 16: 541-551.
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A noval miR-193a-5p-YY1-APC regulatory axis in human endometrioid endometrial adnocarcinoma. Yang YH, Zhou L, Lu LN, Wang LJ, Li X, Jiang PY, Chan LKY, Zhang T, Yu J, Kwong J, Cheung TH, Chung T, Mak D, Sun H, Wang HT. Oncogene 2013 Jul 18;32(29):3432-42.
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Angiogenic vascular endothelial growth factor C is expressed in endometrium and promotes endothelial functions, vascular permeability and angiogenesis and growth of endometriosis. Xu H, Zhang T, Man GCW, May KE, Becker CM, Davis TN, Kung AL, Birsner AE, D’Amato RJ, Wong AWY, Wang CC_. Angiogenesis 2013a;16:541-551.
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Immunology as a Risk Factor and its Role in the Development of Endometriosis. (2013) Endometriosis: Risk Factors, Symptoms and Management. Zhang T, Wang CC. Nova Science, Hauppauge, NY, USA., Chapter 4 p.111-140, ISBN: 9781626187313.
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Prodrug of green tea epigallocatchin-3-gallate (Pro-EGCG) as a potent anti-angiogenesis agent for endometriosis in mice. Wang CC, Xu H, Man GCW, Zhang T, Chu KO, Chu CY, Cheng JT, Li G, He YX, Qin L, Lau TS, Kwong J, Chan TH. Angiogenesis 2013; 16(1): 59 – 69.
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Vascular endothelial growth factor C is increased in endometrium and promotes endothelial functions, vascular permeability and angiogenesis and growth of endometriosis. Xu H, Zhang T, Man GCW, May KE, Becker CM, Davis TN, Kung AL, Birsner AE, D’Amato RJ, Wong AW, Wang CC. Angiogenesis 2013; 16:541-551.
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A Novel miR-193a-5p-YY1-APC Regulatory Axis in Human Endometrioid Endometrial Adenocarcinoma. Yang YH, Zhou L, Lu LN, Wang LJ, Li XX, Jiang PY, Chan LKY, Zhang T, Yu J, Kwong J, Cheung TH, Chung TKH, Mak KKL, Sun H, Wang HT Oncogene 2013;32(29): 3432 - 3442
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Pathological Changes in Early Endometriosis. (2011) Zhang T, Man GCW, Wang CC. Endometriosis – Basic Concepts and Current Research Trend. Intech, Rjelka, Croatia. Chapter 26 p. 459-474, ISBN: 978-953-51-0524-4.