Research Outputs by Postgraduate Students

1Whole genome miRNA profiling revealed miR-199a as potential placental pathogenesis of selective fetal growth restriction in monochorionic twin pregnancies
Meng M, Cheng YKK, Wu L, Chaemsaithong P, Leung MBW, Chim SSC, Sahota DS, Li W, Poon LCY, Wang CC, Leung TY
Placenta Volume 92, March 2020, Pages 44-53
2Low-pass genome sequencing versus chromosomal microarray analysis: implementation in prenatal diagnosis
Wang H, Dong Z, Zhang R, Chau M, Yang Z, Tsang K, Wong HK, Gui B, Meng Z, Xiao K, Zhu X, Wang Y, Chen S, Leung TY, Cheung SW, Kwok YK, Morton CC, Zhu Y, Choy KW
Genet Med, 2020 Mar;22(3):500-510
3Sequencing data of cell-free DNA fragments in living-related liver transplantation for inborn errors of metabolism
Zhu X, Ng HI, Xuan L, Long Y, Mao Y, Shi Y, Sun L, Liang B, Scaglia F, Zhu Z, Choy KW
Data Brief. 2020 Apr; 29: 105183, 6 pages
4Placental microRNA dataset of monochorionic twin pregnancies with and without selective fetal growth restriction
Meng M, Cheng YKK, Wu L, Chaemsaithong P, Leung MBW, Chim SSC, Sahota DS, Li W, Poon LCY, Wang CC, Leung TY
Data in Brief , Volume 30, June 2020, 105403, 5 pages
5Recent Advances in the Noninvasive Prenatal Testing for Chromosomal Abnormalities Using Maternal Plasma DNA
Lau TK, Zhu X, Kwok YKY, Leung TY, Choy KW
Journal of Fetal Medicine, 2020 Mar;7(1):17-23
6Fertility Preservation in Hong Kong Chinese Society: Awareness, Knowledge and Acceptance
Yeung SY, Ng EYL, Lao TTH, Li TC, Chung JPW
BMC Womens Health. 2020 Apr 29;20(1):86
7Association between chronic endometritis and uterine natural killer (uNK) cells density in women with recurrent miscarriage: clinical implications
Chen X, Liu Y, Zhao Y, Cheung WC, Zhang T, Qi R, Chung JPW, Wang CC, Li TC
J Obstet Gynaecol Res. 2020 Jun;46(6):858-863
8Selective growth of mosaic cells in chromosomal analysis of chorionic villi by conventional karyotyping
Zhang Y, Lei Q, Liu J, Lin M, Luo L, Li T, Wang Q, Zhou C
Mol Cell Probes. 2020 Jun;51:101532
1A prospective observational study on the stress levels at the time of embryo transfer and pregnancy testing following in vitro fertilisation treatment: a comparison between women with different treatment outcomes
Cheung CWC, Saravelos SH, Chan TYA, Sahota DS, CC Wang, Chung PW, Li TC
BJOG. 2019 Jan;126(2):271-279
2Comparison of DNA fragmentation levels in spermatozoa with different sex chromosome complements
Shi X, Chan DYL, Zhao MP, Chan CPS, Huang J, Li TC
Reprod Biomed Online. 2019 Jan;38(1):56-65
3Endometrial vascularization characterized by Optical Coherence Tomography and immunohistochemistry in women undergoing in vitro fertilization- embryo transfer treatment
Law TSM, Cheung CWC, Wu F, Zhang R, Chung JPW, Wang RCC, Chen X, Li TC
Medicina (Kaunas). 2019 Mar 27;55(4), 1-12
4Practical Considerations in Providing Preimplantation Genetic Testing for Aneuploidies (PGT-A) (REVIEW)
Yeung QSY, Zhang YX, Chung JPW, Kwok YKY, Gui B, Choy KW, Li TC
Fertility and Reproduction, 1(1), May 2019, 1-9
5Effects of hyperhomocysteinaemia and metabolic syndrome on reproduction in women with polycystic ovary syndrome: a secondary analysis
Chang H, Xie LZ, Ge H, Wu Q, Wen Y, Zhang DJ, Zhang YH, Ma HL, Gao JS, Wang CC, Stener-Victorin E, Ng EHY., Wu XK
Reprod Biomed Online 2019,38(6),990-998
6Analysis of fragment size distribution of cell-free DNA: A potential non-invasive marker to monitor graft damage in living-related liver transplantation for inborn errors of metabolism
Ng H, Zhu X, Xuan L, Long Y, Mao Y, Shi Y, Sun L, Liang B, Scaglia F, Choy KW, Zhu Z
Mol Genet Metab. 2019 May;127(1):45-50
7Screening and prevention of pre-eclampsia: a review (REVIEW)
Chaemsaithong P, Appiah EK , Sahota Daljit , Leung TY, Poon LCY
Hong Kong J Gynaecol Obstet Midwifery 2019;19(1):56-72
8Maternal β-HCG concentrations in early IVF pregnancy: association with the embryo development stage of blastocysts
Zhu W, Yeung QSY, Chan DYL, Chi L, Huang J, Wang Q, Chung JPW, Li TC
Reprod Biomed Online. 2019 May;38(5):683-690
9The high-risk HPV oncogene E7 upregulates miR-182 expression through the TGF-β/Smad pathway in cervical cancer
Chen J, Deng Y, Ao L, Song Y, Xu Y, Wang CC, Choy KW, Chung TKH, Du Q, Sui Y, Yang T, Yang J, Li H, Zou C, Tang T
Cancer Lett. 2019 Sep 24;460:75-85
10Do specific ultrasonography features identified at the time of early pregnancy loss predict fetal chromosomal abnormality? A systematic review and meta-analysis (REVIEW AND META-ANALYSIS)
Huang J, Zhu W, Tang J, Saravelos SH, Poon LCY, Li TC
Genes Dis. 2019 Jun 6(2):129-137
11Mutational analysis of theFAM175A gene in patients with premature ovarian insufficiency
Xu X, Zhang Y, Zhao S, Bian Y, Ning Y, Qin Y
Reprod Biomed Online. 2019 Jun;38(6):943-950
12A prospective study of non-invasive preimplantation genetic testing for aneuploidies (NiPGT-A) using next-generation sequencing (NGS) on spent culture media (SCM)
Yeung QSY, Zhang YX, Chung JPW, Lui WT, Kwok YKY, Gui B, Kong GWS, Cao Y, Li TC, Choy KW
J Assist Reprod Genet. 2019 Aug;36(8):1609-1621
13Development of Coupling Controlled Polymerizations by Adapter-ligation in Mate-pair Sequencing for Detection of Various Genomic Variants in One Single Assay
Dong Z, Zhao X, Li Q, Yang Z, Xi Y, Alexeev A, Shen H, Wang O, Ruan J, Ren H, Wei H, Qi X, Li J, Zhu X, Zhang Y, Dai P, Kong X, Kirkconnell K, Alferov O, Giles S, Yamtich J, Kermani B, Dong C, Liu P, Mi Z, Zhang W, Xu X, Drmanac R, Choy RKW, Jiang Y
DNA Res. 2019 Aug 1;26(4):313-325
14Prenatal Diagnosis of Fetuses with Increased Nuchal Translucency by Genome Sequencing Analysis
Choy KW, Wang H, Shi M, Chen J, Yang Z, Zhang R, Yan H, Wang Y, Chen S, Chau MHK, Cao Y, Chan OYM, Kwok YK, Zhu Y, Chen M, Leung TY, Dong Z
Front Genet. 2019 Aug; volume 10:761 (14 pages)
15Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
Gui B, Zhang Y, Liang B, Kwok YKY, Lui WT, Yeung QSY, Kong L, Xuan L, Chung JPW, Choy KW
J Vis Exp. 2019 Aug 25;(150):e59273, 9 pages
16Reproductive outcomes after surgical treatment of asherman syndrome: A systematic review (REVIEW)
Guo EJ, Chung JPW, Poon LCY, Li TC
Best Pract Res Clin Obstet Gynaecol. 2019 Aug;59:98-114
17A double-blinded, randomized placebo-controlled trial on the effect of traditional Chinese medicine formula Wuzi Yanzong pill on improving semen qualities in men with suboptimal parameters
Zhao M, Chan CPS, Cheung CWC, Alqawasmeh O, Wang RCC, Wu JCY, Lin ZX, Li TC, Chung JPW, Mak JSM, Law TSM, Chan DYL
Trials. 2019 Aug 29;20(1):540 (7 pages)
18A Robust Polymerase Chain Reaction-based Assay for Quantifying Cytosine-guanine-guanine Trinucleotide Repeats in Fragile X Mental Retardation-1 Gene
Wang H, Zhu X, Gui B, Cheung WC, Shi M, Yang Z, Kwok KY, Lim R, Pietilä S, Zhu Y, Choy KW
J Vis Exp. 2019 Sep 16;(151):e59963 (8 pages)
19A comparison of uterine natural killer (uNK) cells density in the peri-implantation period between natural cycles and hormone replacement therapy (HRT) cycles
Yang WJ, Chen X, Zhao Y, Cheung WC, Hsiao SY, Liu Y, Law TSM, Chung JPW, Li TC
Am J Reprod Immunol. 2019 Sep;82(3):e13156 (5 pages)
20Labor progress determined by ultrasound is different in women requiring Cesarean delivery from those who experience a vaginal delivery following induction of labor
Tse WT, Chaemsaithong P, Chan WWY, Kwan AHW, Huang J, Appiah K, Chong KC, Poon LC
Am J Obstet Gynecol. 2019 Oct;221(4):335.e1-335.e18
21Characteristics and mode of inheritance of pathogenic copy number variants in prenatal diagnosis
Chau MHK, Cao Y, Kwok YKY, Chan S, Chan YM, Wang H, Yang Z, Wong HK, Leung TY, Choy KW
Am J Obstet Gynecol. 2019 Nov;221(5):493.e1-493.e11
22Endometrium imaging using real-time rotational optical coherence tomography imaging system: A pilot, prospective and ex-vivo study
Law TSM, Wu F, Xu H, Wang CC, Li TC
Medicine (Baltimore). 2019 Nov;98(44):e17738
23Endocrine characteristics, body mass index, and metabolic syndrome in women with polycystic ovary syndrome
Li J, Wu Q, Wang CC, Wang R, Ng EHY, Liu JP, Mol BWJ, Wu XK, Li WT, PCOSAct Study Group
Reprod Biomed Online. 2019 Nov;39(5):868-876
24The effects of daily meteorological perturbation on pregnancy outcome: Follow-up of a cohort of young women undergoing IVF treatment
Zhao M, Zhang H, Waters THB, Chung JPW, Li TC, Chan DYL.
Environ Health. 2019 Nov 28;18(1):14pages
25Localization of MUC1 in different cell populations of luminal epithelium and changes in expression in women with reproductive failure during implantation window
Wu FR, Mao D, Liu YY, Chen XY, Xu H, Li TC, Wang CC
J Mol Histol. 2019 Dec;50(6):563-572
26Clinical utility of noninvasive prenatal screening for pathogenic copy number variants REPLY
Chau MHK, Sahota DS, Choy KW
Am J Obstet Gynecol. 2019 Dec;221(6):661-662.
27Genetic association of retroesophageal left brachiocephalic vein
Chan YM, Law KM, Poon LC, Luk HM, Cheng KY, Leung TY
Ultrasound Obstet Gynecol. 2019 Dec;54(6):836-837
28The effect of Barberine on Reproduction and Metabolism in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized control trials (REVIEW)
Xie LZ, Zhang DJ, Ma HL, He H, Xia Q, Shen WJ, Chang H, Deng YY, Wu Q, Cong J, Wang CC, Wu Xk.
Evid Based Complement Alternat Med 2019 Dec 13; 2019:7918631
29Prevention of Spontaneous Preterm Birth
Appiah K, Chaemsaithong P, Poon LCY
MIMS JPOG 2019 ; 45 (4); 169-175
1Endometrium Gene Expression and Epigenetic Regulation in Reproductive Failure
Huang J, Zhang R, Wang RCC, Li TC
In: Endometrial Gene Expression, An Emerging Paradigm for Reproductive Disorders, Springer, 2019, Ch7, pp 103-116
1Comparison of rapid MMP-8 and interleukin-6 point-of-care tests to identify intra-amniotic inflammation/infection and impending preterm delivery in patients with preterm labor and intact membranes
Chaemsaithong P, Romero R, Docheva N, Chaiyasit N, Bhatti G, Pacora P, Hassan SS, Yeo L, Erez O
J Matern Fetal Neonatal Med. 2018 Jan;31(2):228-244
2Long non-coding RNA HAND2-AS1 inhibits invasion and metastasis in endometrioid endometrial carcinoma through inactivating neuromedin U
Yang X, Wang CC, Lee WYW, Trovik J, Chung TKH, Kwong J
Cancer Lett. 2018 Jan 28;413:23-34
3The therapeutic effects of a traditional Chinese medicine formula Wuzi Yanzong pill for the treatment of oligoasthenozoospermia: a meta-analysis of randomized controlled trials
Zhao M, Shi X, Kong GWS, Wang RCC, Wu JCY, Lin Z, Li TC, Chan DYL
Evidence-Based Complementary and Alternative Medicine Jan 2018 (2968025): 1-10
4Chronic inflammatory lesions of the placenta are associated with an up-regulation of amniotic fluid CXCR3: A marker of allograft rejection
Maymon E, Romero R, Bhatti G, Chaemsaithong P, Gomez-Lopez N, Panaitescu B, Chaiyasit N, Pacora P, Dong Z, Hassan SS, Erez O
J Perinat Med. 2018 Feb 23;46(2):123-137
5Clinicopathological and prognostic significance of blood microvessel density in endometrial cancer: a meta‑analysis and subgroup analysis
Wang JZ, Xiong YJ, Man GCW, Chen XY, Kwong J, Wang RCC
Arch Gynecol Obstet. 2018 Mar;297(3):731-740
6Effect of exposure to second-hand smoke from husbands on biochemical hyperandrogenism, metabolic syndrome and conception rates in women with polycystic ovary syndrome undergoing ovulation induction
Li J, Wu Q, Wu XK, Zhou ZM, Fu P, Chen XH, Yan Y, Wang X, Yang ZW, Li WL, Stener-Victorin E, Legro RS, Ng EH, Zhang H, Mol BWJ, Wang CC; for PCOSAct Study Group
Hum Reprod. 2018 Apr 1;33(4):617-625
7Comparison of the prevalence of chronic endometritis as determined by means of different diagnostic methods in women with and without reproductive failure
Liu Y, Chen X, Huang J, Wang RCC, Yu MY, Laird S, Li TC
Fertil Steril. 2018 May;109(5):832-839
8Prospective assessment of INTERGROWTH-21st and World Health Organization estimated fetal weight reference curves
Cheng YKY, Lu J, Leung TY, Chan YM, Sahota DS
Ultrasound Obstet Gynecol. 2018 Jun;51(6):792-798
9Decreased MUC1 in endometrium is an independent receptivity marker in recurrent implantation failure during implantation window
Wu F, Chen X, Liu Y, Liang B, Xu H, Li TC, Wang CC
Reprod Biol Endocrinol. 2018 Jun 21;16(1):60
10The impact of music therapy on pain and stress reduction during oocyte retrieval – a randomized controlled trial
Cheung CWC, Wong AWY, Chan PS, Saravelos SH, Chung JPW, Cheung LP, Kong GWS, Li TC
Reprod Biomed Online. 2018 Aug;37(2):145-152
11Uterine artery pulsatility index in the first trimester: assessment of intersonographer and intersampling site measurement differences
Chaemsaithong P, Ting YH, Cheng KYY, Poon CYL, Leung TY, Sahota DS
J Matern Fetal Neonatal Med. 2018 Sep;31(17):2276-2283
12Control of PD-L1 expression by miR-140/142/340/383 and oncogenic activation of the OCT4-miR-18a pathway in cervical cancer
Dong PX, Xiong Y, Yu JH, Chen L, Tang T, Song Y, Hanley SJB, Yue JM, Watari H, Sakuragi N
Oncogene. 2018 Sep; 37(39): 5257-5268
13Pitfalls in assessing chorioamnionicity: novel observations and literature review
Lu J, Cheng YKY, Ting YH, Law KM, Leung TY
Am J Obstet Gynecol. 2018 Sep;219(3):242-254
14Increased expression of angiogenic cytokines in CD56+ uterine natural killer cells from women with recurrent miscarriage
Chen X, Liu Y, Cheung WC, Zhao Y, Huang J, Chung JPW, Wang CC, Li TC
Cytokine. 2018 Oct;110:272-276
15Lifestyle and demographic factors associated with human semen quality and sperm function
Shi X, Chan CPS, Waters T, Chi L, Chan DYL, Li TC
Syst Biol Reprod Med. 2018 Oct;64(5):358-367
16Transverse technique: complementary approach to measurement of first-trimester uterine artery Doppler
Drouin O, Johnson J, Metcalfe A, Huber J, Schwarzenberger J, Winters E, Stavness L, Chaemsaithong P, Tse AWT, Lu J, Lim WT, Leung TY, Bujold E, Sahota D, Poon LCY
Ultrasound Obstet Gynecol. 2018 Nov;52(5):639-647
1HOXA-10 and E-Cadherin Expression in the Endometrium of Women with Recurrent Implantation Failure and Recurrent Miscarriage
Yang Y, Chen X, Saravelos SH, Liu Y, Huang J, Zhang J, Li TC
Fertil Steril 2017 Jan;107(1):136-143.E2
2A comparison of transcriptomic profiles in endometrium during window of implantation between women with unexplained recurrent implantation failure and recurrent miscarriage
Huang J, Qin H, Yang Y, Chen X, Zhang J, Laird S, Wang CC, Chan TF, Li TC
Reproduction 2017 Jun;153(6):749-758
3Correlation between three-dimensional power Doppler and morphometric measurement of endometrial vascularity at the time of embryo implantation in women with unexplained recurrent miscarriage
Chen X, Saravelos SH, Liu Y, Huang J, Wang CC, Li TC.
J Mol Histol 2017 Jun;48(3):235-242
4Chromosome copy number variants in fetuses with syndromic malformations
Wang H, Chau MHK, Cao Y, Kwok KY, Choy KW
Birth Defects Res 2017 Jun;109(10):725-733
5The regulations and role of circadian clock and melatonin in uterine receptivity and pregnancy—An immunological perspective
Man GCW, Zhang T, Chen X, Wang J, Wu F, Liu Y, Wang CC, Cheong Y, Li TC
Am J Reprod Immunol 2017 Aug;78(2)e12715
6Physiological and pathological angiogenesis in endometrium at the time of embryo implantation
Chen X, Man GCW, Liu Y, Wu F, Huang J, Li TC, Wang CC
Am J Reprod Immunol 2017 Aug;78(2)e12693
7Effects of high progesterone level on the day of human chorionic gonadotrophin administration in in vitro fertilization cycles on epigenetic modification of endometrium in the peri-implantation period
Xiong YJ, Wang JZ, Liu L, Chen XY, Xu H, Li TC, Wang CC, Zhang SY
Fertil Steril 2017 Aug;108(2):269-276
8Development of a novel immunoassay to detect interactions with the transactivation domain of p53: application to screening of new drugs
Xiong Y, Wu Y, Luo S, Gao Y, Xiong YJ, Chen D, Deng H, Hao W, Liu T, Li M
Sci Rep 2017 Aug 23;7(1):9185
9Protocol for measurement of mean arterial pressure at 10–40 weeks’ gestation
Roberts L, Chaemsaithong P, Sahota DS, Nicolaides KH, Poon LCY
Pregnancy Hypertens 2017 Oct;10:155-160
10Measurement of uterine natural killer (uNK) cell percentage in the peri-implantation endometrium from fertile women and women with recurrent reproductive failure: establishment of a reference range.
Chen XY, Mariee N, Jiang LM, Liu YY, Wang CC, Li TC, Laird S
Am J Obstet Gynecol 2017 Dec, 217(6),680.e1-6.
11Inhibition of coiled coil domain containing protein 69 enhances platinum-induced apoptosis in ovarian cancer cells
Cui L, Liang B, Yang Y, Zhu M, Kwong J, Zheng H, Wang CC
Oncotarget 2017 Dec, 8 (60), pp. 101634-101648
12Development of a novel immunoassay to detect interactions with the transactivation domain of p53: Application to screening of new drugs
Xiong Y, Wu Y, Luo S, Gao Y, Xiong YJ, Chen D, Deng H, Hao W, Liu, T, Li M
Sci Rep 2017 Dec, 7 (1), art. no. 9125
13Transcriptomic profiles in peripheral blood between women with unexplained recurrent implantation failure and recurrent miscarriage and the correlation with endometrium: A pilot study
Huang J, Jin N, Qin H, Shi X, Liu Y, Cheung W, Wang CC, Chan TF, Li TC
PLoS One. 2017 Dec 7;12(12):e0189159
1Copy-Number Variants Detection by Low-Pass Whole-Genome Sequencing
Dong Z, Xie, W, Chen, H, Xu, J, Wang, H, Li, Y, Wang, J, Chen, F, Choy KW, Jiang H
Curr Protoc Hum Genet 2017 Jul 11;94:8 17 1-8 17 16
1Transdermal Delivery of siRNA through Microneedle Array.
Deng Y*, Chen J*, Zhao Yi*, Yan X, Zhang L, Choy KW, Hu J, Sant HJ, Gale BK, Tang T (*co-1st authors)
Sci Rep Feb 2016;6 (21422): 1 – 8
2Hypoxia Inducible Factor and Microvessels in Peri-implantation Endometrium of Women with Recurrent Miscarriage.
Chen XY, Jiang LM, Wang CC, Huang J, Li TC
Fertil Steril Jun 2016;105(6): 1496 – 1502
3Risk Factors for Ectopic Pregnancy in Assisted Reproductive Technology: A 6-Year, Single-Center Study.
Bu Z*, Xiong Y*, Wang K, Sun Y (*co-1st authors)
Fertil Steril Jul 2016;106(1): 90 - 94
4Local Administration of siRNA through Microneedle: Optimization, Bio-distribution, Tumor Suppression and Toxicity.
Tang T*, Deng Y*, Chen J, Zhao Y, Yue RF, Choy KW, Wang CC, Du Q, Xu Y, Han L, Chung TKH (*co-1st authors)
Sci Rep Jul 2016;6 (30430): 1 - 8
5Genetic Variants Associated with Gestational Diabetes Mellitus: A Meta-analysis and Subgroup Analysis.
Wu L, Cui L, Tam WH, Ma RCW, Wang CC
Sci Rep Jul 2016;6 (30539): 1 - 9
6Low-pass Whole-genome Sequencing in Clinical Cytogenetics: A Validated Approach.
Dong Z*, Zhang J*, Hu P*, Chen H, Xu J, Tian Q, Meng L, Ye Y, Wang J, Zhang M, Li Y, Wang HL, Yu S, Chen F, Xie J, Jiang H, Wang W, Choy KW, Xu Z (*co-1st authors)
Genet Med Sep 2016;18(9): 940 – 948
1RA induces differentiation of multipotent P19 cells towards male germ cell.
Zhang L, Tang J, Haines CJ, Feng H, Teng X, Han Y.
In Vitro Cell Dev Biol Anim. 2015 Jan;51(1):85-91.
2LncRNA Dum interacts with Dnmts to regulate Dppa2 expression during myogenic differentiation and muscle regeneration.
Wang L, Zhao Y, Bao X, Zhu X, Kwok YK, Sun K, Chen X, Huang Y, Jauch R, Esteban MA, Sun H, Wang H.
Cell Res. 2015 Mar;25(3):335-50.
3Safety of Chinese herbal medicines during pregnancy.
Liang B, Li L, Tang LY, Wu Q, Wu XK, Wang CC.
J Appl Toxicol. 2015 May;35(5):447-58.
4Prognostic value of circulating tumor cells and disseminated tumor cells in patients with ovarian cancer: a systematic review and meta-analysis.
Cui L, Kwong J, Wang CC.
J Ovarian Res. 2015 Jun 16;8(1):38.
5Differential expression of vascular endothelial growth factor angiogenic factors in different endometrial compartments in women who have an elevated progesterone level before oocyte retrieval, during in vitro fertilization-embryo transfer treatment.
Chen X, Jin X, Liu L, Man CW, Huang J, Wang CC, Zhang S, Li TC.
Fertil Steril. 2015 Oct;104(4):1030-6.