Academic Publications in Fetal Medicine

 

The Fetal Medicine Team has a wide research interests not only  in Down syndrome screening and prenatal genetic diagnosis, but also in preterm birth, fetal growth restriction, as well as fetal therapy. The following are the highlights of our publications.

 

Down syndrome Screening

Our unit have long and strong track record in studying the implementation of first trimester combined screening for Down syndrome since 2003 (Leung et al UOG 2007, Leung et al JMFNM 2009). We have derived the Chinese specific logarithm in risk calculation (Leung et al AJOG 2008, Sahota et al UOG 2009a, Sahota UOG 2009b, Sahota UOG 2010), and training and prospective quality control_ program are essential in maintaining high detection rate (90%) and low false positive rate (5%) of the screening program (Sahota et al JNFNM 2011Sahota et al JNFNM 2012).

 

Prenatal Genetic Diagnosis

CUHK is the pioneer in using circulating fetal DNA in maternal plasma for non-invasive prenatal diagnosis (Chiu et al BMJ 2011, Cheung et al NEJM 2015, Leung et al Prenat Dx 2013), to which the Fetal Medicine Team had made a significant contribution. The Team also studied the various new genomic methods in prenatal diagnosis, including array comparative genomic hybridization (aCGH) (Leung et al UOG 2011), BAC-on Beads (Choy et al BJOG 2014), and massively parallel sequencing, which revealed their accuracy and effectiveness in clinical use.

 

Preterm Birth

Our studies have found that in our Chinese population the epidemiology and underlying causes of preterm birth are quite different from those of in Western countries (Hui et al In J GO 2014). Hence the predictive value of routine cervical length measurement at 20 weeks of gestation for preterm delivery is lower when compared to the Caucasians (Leung et al UOG 2005). More interestingly, our RCT on the prophylactic use cerclage pessary in preventing preterm delivery show negative result, in contrast to the Spanish study (Hui et al AJP 2013). We have also been studying various biochemical markers to preterm the risk of preterm labor or delivery (Chim et al PLoS One 2012).

 

Fetal Growth Restriction

Our Chinese specific Fetal growth charts (CRL: Sahota et al UOG 2009; BPD, HC, AC, FL: Leung et al UOG 2008) are highly evaluated by the Inter-growth Study Group. We have also been studying various biophysical and biochemical markers to predict fetal growth restriction (Leung et al UOG 2006, Leung et al UOG 2008, Pang et al Prenat Dx 2009, Law et al UOG 2009)

 

Fetal Therapy

Our Team is the leading centre of fetal therapy in Hong Kong and in China. We have reported the implementation of various therapeutic modalities for fetal abnormalities including fetoscopic laser coagulation for twin-twin transfusion syndrome (Lau et al CMJ 2004), radiofrequency ablation of umbilical cord for selective fetal reduction in complicated MC twin pregnancies (Lu et al Fetal Dx Tx 2013),  pleurodesis for fetal chylothorax using OK432 (Leung HKMJ 2012 ), and USG guided embolization of large chorioangioma (Lau et al BJOG 2003 ; Lau et al BJOG 2005; Cheng et al Fetal Dx Tx 2016)

 

The selected publications  in prenatal genetic diagnosis, preterm birth, fetal growth restriction, and fetal therapy

 


Prenatal Genetic Diagnosis

  • Diagnostic accuracy of the BACs-on-Beads™ assay versus karyotyping for prenatal detection of chromosomal abnormalities: a retrospective consecutive case series.
    Choy K, Kwok Y, Cheng Y, Wong K, Wong H, Leung K, Suen K, Adler K, Wang C, Lau T, Schermer M, Lao T, Leung TY.
    BJOG 2014; 121:1245-52.
  • Is High Fetal Nuchal Translucency Associated with Submicroscopic Chromosomal Abnormalities by Array CGH?
    Huang J, Poon LC, Akolekar R, Choy KW, Leung TY, Nicolaides KH.
    Ultrasound Obstet Gynecol 2014; 43:620-4.
  • Noninvasive twin zygosity assessment and aneuploidy detection by maternal plasma DNA sequencing.
    Leung TY,
    Qu JZ, Liao GJ, Jiang P, Cheng YK, Chan KC, Chiu RW, Lo YM.
    Prenat Diagn 2013; 33:675-81
  • Noninvasive Prenatal Determination of Twin Zygosity by Maternal Plasma DNA Analysis.
    Qu JZZ, Leung TY (co-1st author), Jiang P, Liao GJW, Cheng YKY, Sun H, Chiu RWK, Chan KCA, Lo YM.
    Clin Chem 2013; 59:427-35.
  • Identification of submicroscopic chromosomal aberrations in fetuses with increased nuchal translucency and an apparently normal karyotype.
    Leung TY
    , Vogel I, Lau TK, Chong W, Hyett JA, Petersen OB, Choy KW.
    Ultrasound Obstet Gynecol 2011; 38: 314-319.
  • Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study.
    Chiu RW, Akolekar R, Zheng YW, Leung TY, Sun H, Chan KC, Lun FM, Go AT, Lau ET, To WW, Leung WC, Tang RY, Au-Yeung SK, Lam H, Kung YY, Zhang X, van Vugt JM, Minekawa R, Tang MH, Wang J, Oudejans CB, Lau TK, Nicolaides KH, Lo YM.
    BMJ. 2011 Jan 11; 342:c7401.
  • Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus.
    Lo YM, Chan KC, Sun H, Chen EZ, Jiang P, Lun FM, Zheng YW, Leung TY, Lau TK, Cantor CR, Chiu RW.
    Sci Transl Med. 2010; 2(61):61ra91.
  • Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma.
    Chiu RW, Chan KC, Gao Y, Lau VY, Zheng W, Leung TY, Foo CH, Xie B, Tsui NB, Lun FM, Zee BC, Lau TK, Cantor CR, Lo YM.
    Proc Natl Acad Sci USA 2008; 105: 20458-20463.

 


Preterm birth

  • Cerclage Pessary for Preventing Preterm Birth in Women with a Singleton Pregnancy and a Short Cervix at 20 to 24 Weeks: A Randomized Controlled Trial.
    Hui SY, Chor CM, Lau TK, Lao TT, Leung TY.
    Am J Perinatol 2013; 30:283-8.
  • Systematic Identification of Spontaneous Preterm Birth-Associated RNA Transcripts in Maternal Plasma.
    Chim SS, Lee WS, Ting YH, Chan OK, Lee SW, Leung TY.
    PLoS One 2012; 7: e34328.
  • Cervical length at 18-22 weeks of gestation for the prediction of spontaneous preterm delivery in Hong Kong Chinese women.
    Leung TN, Pang MW, Leung TY, Poon CF, Wong SM, Lau TK.
    Ultrasound Obstet Gynecol 2005; 25: 713-717.
  • Risk and prediction of preterm delivery in pregnancies complicated by antepartum hemorrhage of unknown origin before 34 week.
    Leung TY
    , Chan LW, Tam WH, Leung TN, Lau TK.
    Gynecol Obstet Invest 2001; 52: 227-231.

 


Fetal Growth Restriction

  • Which ultrasound or biochemical markers are independent predictors of small-for-gestational age?
    Law LW, Leung TY, Sahota DS, Chan LW, Fung TY, Lau TK.
    Ultrasound Obstet Gynecol 2009; 34:283-287.
  • A strategy for identifying circulating placental RNA markers for fetal growth assessment.
    Pang WW, Tsui MH, Sahota DS, Leung TY, Lau TK, Lo YM, Chiu RW.
    Prenat Diagn 2009; 29: 495-504.
  • Prediction of birth weight by crown-rump length and maternal serum levels of pregnancy associated plasma protein A in the first trimester.
    Leung TY
    , Sahota DS, Chan LW, Law LW, Fung TY, Leung TN, Lau TK.
    Ultrasound Obstet Gynecol. 2008; 31: 10-1
  • First trimester maternal serum levels of placental hormones are independent predictors of second trimester fetal growth parameters.
    Leung TY
    , Chan LW, Leung TN, Fung TY, Sahota DJ, Lau TK.
    Ultrasound Obstet Gynecol 2006; 27: 156-161.

 


Fetal Therapy

  • Radiofrequency Ablation for Selective Reduction in Complicated Monochorionic Multiple Pregnancies.
    Lu J, Ting YH, Law KM, Lau TK, Leung TY.
    Fetal Diagn Ther 2013; 34:211-6.
  • Intrapleural injection of OK-432 as the primary in-utero treatment for fetal chylothorax.
    Leung VK, Suen SSh, Ting YH, Law LW, Lau TK, Leung TY.
    Hong Kong Med J 2012; 18:156-9.
  • Fetoscopic laser photocoagulation in the management of twin-twin transfusion syndrome: local experience from Hong Kong.
    Yang X, Leung TY, Ngan Kee WD, Chen M, Chan LW, Lau TK.
    Hong Kong Med J 2010; 16: 275-281
  • Prenatal embolisation of large chorioangioma using enbucrilate.
    Lau TK, Yu CH, Leung TY, To KF, Fung TY, Leung TN.
    BJOG 2005 112: 1002-4.

 

 

 

1Low-pass Whole-genome Sequencing in Clinical Cytogenetics: A Validated Approach.
Dong Z, Zhang J, Hu P, Chen H, Xu J, Tian Q, Meng L, Ye Y, Wang J, Zhang M, Li Y, Wang HL, Yu S, Chen F, Xie J, Jiang H, Wang W, Choy KW, Xu Z
Genet Med 2016;18(9): 940 - 948
2Pseudoamniotic Band Syndrome after In Utero Intervention for Twin-to-Twin Transfusion Syndrome: Case Reports and Literature Review.
Ting YH, Lao TTH, Law KM, Cheng YKY, Lau TK, Leung TY
Fetal Diagn Ther 2016;40(1): 67 - 72
3Validation of a Robust PCR-Based Assay for Quantifying Fragile X CGG Repeats.
Kwok YKY, Wong CKM, Lo FM, Kong GWS, Moore JK, Wu S, Lam STS, Schermer M, Leung TY, Choy KW
Clin Chim Acta 2016;456(2016): 137 - 143
4Aflatoxin B1 Augments the Synthesis of Corticotropin Releasing Hormone in JEG-3 Placental Cells.
Wang YF, Tan WJ, Wang CC, Leung LK
Chem-Biol Interact 2015;237(2015): 73 - 79
5Assessing Quality Standards in Measurement of Uterine Artery Pulsatility Index At 11 to 13 + 6 Weeks Gestation.
Ridding G, Hyett JA, Sahota DS, McLennan A
Ultrasound Obst Gyn 2015;46(3): 299 - 305
6Safety of Chinese Herbal Medicines during Pregnancy.
Liang Bo, Li L, Tang LY, Wu Q, Wu XK, Wang CC
J Appl Toxicol 2015;35(5): 447 - 458
7Seasonality of Fetal Trisomy 21 - Have Ambient Air Pollutants Played A Role?
Chung MK, Lao TTH, Ting YH, Wong TW, Leung TY
J Matern Fetal Neonatal Med 2015;28(5): 552 - 557
8SNaPshot Reveals High Mutation and Carrier Frequencies of 15 Common Hearing Loss Mutants in a Chinese Newborn Cohort.
Chen Y, Cao Ye, Li HB, Mao J, Liu MJ, Liu YH, Wang BJ, Jiang D, Zhu Q, Ding Y, Wang W, Li H, Choy KW
Clin Genet 2015;87(5): 467 - 472
9A Study of the Immune Properties of Human Umbilical Cord Lining Epithelial Cells.
Cai YJ, Huang L, Leung TY, Burd A
Cytotherapy 2014;16(5): 631 - 639
10Does Gestational Diabetes Mellitus Affect Respiratory Outcome in Late-Preterm Infants?
Fung GPG, Chan MLM, Ho Y, To WWK, Chan BHB, Lao TTH
Early Hum Dev 2014;90(9): 527 - 530
11Expression Profile of Cord Blood Neutrophils and Dysregulation of HSPA1A and OLR1 upon Challenge by Bacterial Peptidoglycan.
Fong ON, Chan KYY, Leung KT, Lam HS, Cheung HM, Leung TY, Li KKH, Ng PC
J Leukoc Biol 2014;95(1): 169 - 178
12Non-Invasive Prenatal Testing for Fetal Chromosomal Abnormalities by Low-Coverage Whole-Genome Sequencing of Maternal Plasma DNA: Review of 1982 Consecutive Cases in a Single Center.
Lau TK, Cheung SW, Lo PSS, Pursley AN, Chan MK, Jiang F, Zhang H, Wang W, Jong LFJ, Yuen OKC, Chan HYC, Chan WSK, Choy KW
Ultrasound Obst Gyn 2014;43(3): 254 - 264
13Potential application of fetal epigenetic markers on the non-invasive prenatal detection of chromosomal abnormality.
Chim SSC
Clin Chem Lab Med 2014;52(5): 585 - 588
14Recurrent Structural Malformations Identified among Mowat–Wilson Syndrome Fetuses.
Zhou Y, Huang J, Cheng YKY, Leung TY, Pooh RK, Lo FM, Choy KW
Prenatal Diag 2014;34(3): 296 - 298
15Bisphenol A Differentially Activates Protein Kinase C Isoforms in Murine Placental Tissue.
Tan WJ, Huang H, Wang YF, Wong TY, Wang CC, Leung LK
Toxicol App Pharm 2013;269(2): 163 - 168
16Carbimazole Embryopathy in a Chinese Population: Case Series and Literature Review.
Ting YH, Zhou Y, Lao TTH
Birth Defects Res Part A-Clin Mol Teratol 2013;97(4): 225 - 229
17Melamine in Prenatal and Postnatal Organs in Rats.
Chu NCY, Chu KO, Ho CS, Kwok SS, Chan HMM, Fung KP, Wang CC
Reprod Toxicol 2013;35: 40 - 47
18光谱核型分析联合微阵列比较基因组杂交诊断15号环状染色体综合征.
Pan M, Choy KW, Liao C, Lau TK
Chin J Med Genet 2012;29(5): 562 - 565
19胎儿镜下激光凝固胎盘吻合血管术治疗双胎输血综合征33例临床分析.
Liu XX, Lau TK, Wang HF, Wong SM, Leung TY
Chin J Obstet Gynecol 2012;47(8): 587 - 591
20Comparison of Real-time Three-Dimensional Echocardiography and Spatiotemporal Image Correlation in Assessment of Fetal Interventricular Septum.
Xiong Y, Liu T, Wu Y, Xu JF, Ting YH, Leung TY, Lau TK
J Matern Fetal Neonatal Med 2012;25(11): 2333 - 2338
21Intrapleural Injection of OK-432 as the Primary In-utero Treatment for Fetal Chylothorax.
Leung VKT, Suen SSH, Ting YH, Law LW, Lau TK, Leung TY
Hong Kong Med J 2012;18(2): 156 - 159
22Maternal HBsAg Status and Infant Size - a Faustian Bargain?
Lao TTH, Sahota DS, Suen SSH, Law LW, Leung TY
J Viral Hepatitis 2012;19(7): 519 - 524
23Molecular Genetics in Fetal Neurology.
Huang J, Wah IYM, Pooh RK, Choy KW
Semin Fetal Neona M 2012;17(6): 341 - 346
24Molecular Studies of the Congenital Malformation Induced by Largehead Atractylodes Rhizome, the Most Commonly Used Chinese Medicine for Threatened Miscarriage.
Tang LY, Li L, Borchert A, Lau CBS, Leung PC, Wang CC
Mol Hum Reprod 2012;18(12): 585 - 592
25Prenatal Detection of Aneuploidy and Imbalanced Chromosomal Arrangements by Massively Parallel Sequencing.
Dan S, Chen F, Choy KW, Jiang FM, Lin JR, Xuan ZL, Wang W, Chen SP, Li XC, Jiang H, Leung TY, Lau TK, Su Y, Zhang WY, Zhang XQ
PLos ONE 2012;7(2): e27835
26Safety Evaluation of Commonly Used Chinese Herbal Medicines during Pregnancy in Mice
Wang CC, Li L, Tang LY, Leung PC
Hum Reprod 2012;27(8): 2448 - 2456
27Successful Treatment of Severe Fetal Chylothorax Resistant to Repeated Pleuroamniotic Shunting by OK-432 Pleurodesis.
Lo TK, Lau WL, Lam YY, Tang MHY, Leung TY, Leung WC
Fetal Diagn Ther 2012;31(4): 260 - 263
28Gene Dosage Imbalance of Human Chromosome 21 in Mouse Embryonic Stem Cells Differentiating to Neurons.
Wang CC, Kazuki Y, Oshimura M, Ikeo K, Gojobori T
Gene 2011;481(2): 93 - 101
29Gestational and Lactational Transfer of Melamine following Gavage Administration of a Single Dose to Rats.
Chan JYW, Lau CM, Ting TL, Mak CWT, Chan HMM, Lam CWK, Ho CS, Wang CC, Fok TF, Fung KP
Food Chem Toxicol 2011;49(7): 1544 - 1548
30Identification of Submicroscopic Chromosomal Aberrations in Fetuses with increased Nuchal Translucency and Apparently Normal Karyotype.
Leung TY, Vogel I, Lau TK, Chong WS, Hyett JA, Petersen OB, Choy KW
Ultrasound Obst Gyn 2011;38(3): 314 - 319
31Interactive Expressions of HtrA1 and VEGF in Human Vitreous Humors and Fetal RPE Cells.
Ng TK, Yam HF, Chen WQ, Lee VYW, Chen H, Chen LJ, Choy KW, Yang Z, Pang CCP
Invest Ophthalmol Vis Sci 2011;52(6): 3706 - 3712
32The Impact of Fetal Gender on Preterm Birth in a Southern Chinese Population.
Lao TTH, Sahota DS, Suen SSH, Law LW, Leung TY
J Matern Fetal Neonatal Med 2011;24(12): 1440 - 1443
33X-Linked Congenital Hypertrichosis Syndrome Is Associated with Interchromosomal Insertions Mediated by a Human-Specific Palindrome near SOX3.
Zhu HW, Shang DD, Sun M, Choi SJ, Liu Q, Hao JJ, Figuera LE, Zhang F, Choy KW, Ao Y, Liu Y, Zhang XL, Yue FZ, Wang MR, Jin L, Patel PI, Jing T, Zhang X
Am J Hum Genet 2011;88(6): 819 - 826
34先天性心臟病患兒22q11微缺失的定量螢光聚合酶鏈反應檢測
22q11 Microdeletion Test in Patients with Congenital Heart Defects by Quantitative Fluorescent PCR.
Chen Y, Mao J, Kwok YKY, Kan HJ, Li HB, Liu MJ, Sun Y, Yan WH, Li H, Choy KW
Chin J Med Genet 2010;27(5): 571 - 575
35A Novel Mutation of GATA4 in a Familial Atrial Septal Defect.
Chen Y, Mao J, Sun Y, Zhang Q, Cheng HB, Yan WH, Choy KW, Li H
Clin Chim Acta 2010;411(21): 1741 - 1745
36Classification of Pathogenic or Benign Status of CNVs Detected by microarray Analysis.
Leung TY, Pooh RK, Wang CC, Lau TK, Choy KW
Expert Rev Mol Diagn 2010;10(6): 717 - 721
37Distribution of Melamine in Rat Foetuses and Neonates.
Chu NCY, Chu KO, Chan JYW, Liu XZ, Ho CS, Wong CK, Lau CM, Ting TL, Fok TF, Fung KP, Wang CC
Toxicol Lett 2010;199(3): 398 - 402
38Effect of Long-Term Storage on Placental Growth Factor and FMS-Like Tyrosine Kinase 1 Measurements in Samples from Pregnant Women.
Law LW, Sahota DS, Chan LW, Chen M, Lau TK, Leung TY
J Matern Fetal Neonatal Med 2010;23(12): 1475 - 1480
39Epigenetic-Genetic Chromosome Dosage Approach for Fetal Trisomy 21 Detection Using an Autosomal Genetic Reference Marker.
Tong YK, Chiu RWK, Akolekar R, Leung TY, Lau TK, Nicolaides KH, Lo DYM
PLos ONE 2010;5(12): e15244
40Fetoscopic Laser Photocoagulation in the Management of Twin-Twin Transfusion Syndrome: Local Experience from Hong Kong.
Yang X, Leung TY, Ngan Kee WD, Chen M, Chan LW, Lau TK
Hong Kong Med J 2010;16(4): 275 - 281
41Making Decisions When No Good Choices Exist:Delivery of the Survivor after Intrauterine Death of the Co-Twin in Monochorionic Twin Pregnancies.
Evans MI, Lau TK
Fetal Diagn Ther 2010;28(4): 191 - 195
42Novel and Homozygous Best1 Mutations in Chinese Patients with Best Vitelliform Macular Dystrophy.
Wong RLM, Hou P, Choy KW, Chiang WY, Tam POS, Li HT, Chan WM, Lam DSC, Pang CCP, Lai TYY
Retina 2010;30(5): 820 - 827
43Second-Trimester Detection of Mowat-Wilson Syndrome Using Comparative Genomic Hybridization Microarray Testing.
Choy KW, To KF, Chan AWH, Lau TK, Leung TY
Obstet Gynecol 2010;115(2): 462 - 465
44A strategy for identifying circulating placental RNA markers for fetal growth assessment.
Pang WWI, Tsui MHY, Sahota DS, Leung TY, Lau TK, Lo DYM, Chiu Rossa WK
Prenatal Diag 2009;29(5): 495 - 504
45Adipose-derived stem cells from pregnant women show higher proliferation rate unrelated to estrogen.
Ng LWC, Yip SK, Wong HK, Yam HF, Liu YM, Lui WT, Wang CC, Choy KW
Hum Reprod 2009;24(5): 1164 - 1170
46Comparison of conventional and PureWave Crystal transducer in obstetric sonography.
Yu YM, Chen M, Xiong Y, Chau MMC, Li RSH, Lau TK
J Matern Fetal Neonatal Med 2009;22(7): 616 - 621
47First-trimester fetal nasal bone length in an ethnic Chinese population.
Sahota DS, Leung TY, Chan LW, Law LW, Fung TY, Chan OK, Lau TK
Ultrasound Obst Gyn 2009;34(1): 33 - 37
48Non-invasive Prenatal Detection of Fetal Trisomy 18 by RNA-SNP Allelic Ratio Analysis Using Maternal Plasma SERPINB2 mRNA: a Feasibility Study.
Tsui NBY, Wong CK, Leung TY, Lau TK, Chiu RWK, Lo DYM
Prenatal Diag 2009;29(11): 1031 - 1037
49Which Ultrasound or Biochemical Markers are Independent Predictors of Small-for-Gestational Age?
Law LW, Leung TY, Sahota DS, Chan LW, Fung TY, Lau TK
Ultrasound Obst Gyn 2009;34(3): 283 - 287
50Comparison of Nuchal and Detailed Morphology Ultrasound Examinations in Early Pregnancy for Fetal Structural Abnormality Screening: A Randomized Controlled Trial.
Chen M, Lee CP, Lam YH, Tang RYK, Chan BCP, Wong SF, Tse LHY, Tang MHY
Ultrasound Obst Gyn 2008;31(2): 136 - 146
51Rapid aneuploidy testing (knowing less) versus traditional karyotyping (knowing more) for advanced maternal age: what would be missed, who should decide?
Leung WC, Lau ET, Lau WL, Tang RYK, Wong SF, Lau TK, Tse KT, Wong SF, To WWK, Ng LKI, Lao TTH, Tang MHY
Hong Kong Med J 2008;14(1): 6 - 13
52Repeat Antenatal Corticosteroids: Should it be Prescribed and if so when and how?
Leung TY, Sahota DS
Fetal and Maternal Medicine Review 2008;19(2): 165 - 180
53Side-Effect and Vital Sign Profile of Nifedipine as a Tocolytic for Preterm Labour.
Chan LW, Sahota DS, Yeung SY, Leung TY, Fung TY, Lau TK, Leung TN
Hong Kong Med J 2008;14(4): 267 - 272
54The Application of Microarray Based Comparative Genomic Hybridization in Prenatal Diagnosis.
Choy KW, Tsang PT, Leung TY, Wang CC, Lau TK
Fetal and Maternal Medicine Review 2008;19(2): 119 - 133
55双胎输血综合征的判断和临床处理
Wang HF, Lau TK
Chin J Prac Gynecol Obstet 2007;23(5): 347 - 351
56先天性膈疝的产前诊断及宫内治疗进展
乔宠, Lau TK, Jani J, Deprest J
Chin J Obstet Gynecol 2007;42(8): 563 - 566
57Digital PCR for the molecular detection of fetal chromosomal aneuploidy.
Lo DYM, Lun FMF, Chan AKC, Tsui NBY, Chong KC, Lau TK, Leung TY, Zee BCY, Cantor CR, Chiu Rossa WK
Proc Natl Acad Sci USA 2007;104(32): 13116 - 13121
58Fetal parvovirus B19 infection in a twin pregnancy with 1 twin presenting with hydrops fetalis and the other asymptomatic: a case report.
Leung TN, Leung TY, Chan PKS, Fung TY, Lau TK
J Reprod Med 2007;52(5): 419 - 421
59Foetal intracranial teratoma: choosing the best time and mode of delivery.
Chan LW, Leung TY, Leung TN, Fung TY, Lau TK
Hong Kong Med J 2007;13(4): 323 - 326
60Hypermethylation of RASSF1A in Human and Rhesus Placentas.
Chiu Rossa WK, Chim SSC, Wong IHN, Wong CSC, Lee CWS, To KF, Tong JHM, Yuen KC, Shum ASW, Chan JKC, Chan LYS, Yuen WF, Tong YK, Weier JF, Ferlatte C, Leung TN, Lau TK, Lo KW, Lo DYM
Am J Pathol 2007;170(3): 941 - 950
61Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection.
Lo DYM, Tsui NBY, Chiu Rossa WK, Lau TK, Leung TN, Heung MS, Gerovassili A, Jin Yongjie, Nicolaides KH, Cantor CR, Ding CM
Natl Med J China 2007;13(2): 218 - 223
62Safety Profiles of Chinese Herbal-Medicines in Early Embyro Development.
Wang CC, Lau TK
Clin Chem Lab Med 2007;45: S311
63Dextrocardia in pregnancy: 20 years experience.
Fung TY, Chan LW, Leung TN, Leung TY, Lau TK
J Reprod Med 2006;51(7): 573 - 577
64Effect of rosiglitazone on embryonic growth and morphology: a study using a whole rat embryo culture model.
Chan Louis YS, Lau TK
Fertil Steril 2006;86(2): 490 - 492
65Fetal anaemia as a cause of fetal injury: diagnosis and management.
Chan LW, Lau TK, Chung TKH
Curr Opin Obstet Gyn 2006;18(2): 100 - 105
66First-trimester maternal serum level of pregnancy-associated plasma protein-A is an independent predictor of fetal maxillary bone length.
Leung TY, Chan LW, Leung TN, Fung TY, Sahota DS, Lau TK
Ultrasound Obst Gyn 2006;27(1): 9 - 12
67First-trimester maternal serum levels of placental hormones are independent predictors of second-trimester fetal growth parameters.
Leung TY, Chan LW, Leung TN, Fung TY, Sahota DS, Lau TK
Ultrasound Obst Gyn 2006;27(2): 156 - 161
68Foetal magnetic resonance imaging.
Wong TYY, Lam WWM, Lau TK
Hong Kong Med J 2006;12(6): 486 - 487
69Prediction of intrapartum Cesarean delivery for non-reassuring fetal status after a successful external cephalic version by a low pre-version pulsatility index of the fetal middle cerebral artery.
Leung TY, Fok AWY, Chan LW, Law LW, Lau TK
Ultrasound Obst Gyn 2006;27(4): 416 - 419
70The utility assessment of Chinese pregnant women towards the birth of a baby with Down syndrome compared to a procedure-related miscarriage.
Chan YM, Leung TN, Leung TY, Fung TY, Chan LW, Lau TK
Prenatal Diag 2006;26(9): 819 - 824
71Cervical length at 18 - 22 weeks of gestation for prediction of spontaneous preterm delivery in Hong Kong Chinese women.
Leung TN, Pang MW, Leung TY, Poon CF, Wong SM, Lau TK
Ultrasound Obst Gyn 2005;26(7): 713 - 717
72Higher median levels of free beta-hCG and PAPP-A in the first trimester of pregnancy in a Chinese ethnic group. Implication for first trimester combined screening for Down's syndrome in the Chinese population.
Leung TY, Spencer K, Leung TN, Fung TY, Lau TK
Fetal Diagn Ther 2005;21(1): 140 - 143
73A cross-sectional, single-centre study on the levels & sources of mercury, cadmium & lead in a HK mother-infant cohort. (Ref. 212917)
Fok TF, Lam CWK, Yip SK, Sin NC, Ng PC, Leung PHY
HCPF 2004;
74Helper T Lymphocyte Related Chemokines in Healthy Newborns.
Leung TF, Ng PC, Tam WH, Li BCY, Wong E, Ma TPY, Lam CWK, Fok TF
Pediatr Res 2004;55(2): 334 - 338
75Systematic micro-array based identification of placental mRNA in maternal plasma: towards non-invasive prenatal gene expression profiling.
Tsui NBY, Chim SSC, Chiu Rossa WK, Lau TK, Ng EKO, Leung TN, Tong YK, Chan AKC, Lo DYM
J Med Genet 2004;41(6): 461 - 467
76Cord blood thyroid-stimulating hormone level in high-risk pregnancies.
Chan Louis YS, Chiu PY, Lau TK
Eur J Obstet Gyn R B 2003;108(2): 142 - 145
77Cord blood thyroid-stimulating hormone level in twin pregnancy.
Chan Louis YS, Chiu PY, Lau TK
Acta Obstet Gyn Scan 2003;82(1): 28 - 31
78Craniofacial Anthropometry of Hong Kong Chinese Babies: the Eye.
Fok TF, Hon EKL, So HK, Wong E, Ng PC, Lee AKY, Chang AMZ
Orthod Craniofacial Res 2003;6(1): 48 - 53
79Customizing fetal biometric charts.
Pang MW, Leung TN, Sahota DS, Lau TK, Chang AMZ
Ultrasound Obst Gyn 2003;22(3): 271 - 276
80Facial Anthropometry of Hong Kong Chinese Babies.
Fok TF, Hon EKL, So HK, Wong E, Ng PC, Lee AKY, Chang AMZ
Orthod Craniofacial Res 2003;6(3): 164 - 172
81First Trimester Human Trophoblast Production Of Placental Corticotrophin-Releasing Hormone (CRH) Is Unresponsive To Hypoxia In-Vitro.
Choy MY, Leung TN, Leung PS, Lau TK
Early Pregnancy: Biology and Medicine 2003;4(1): 235 - 247
82mRNA of placental origin is readily detectable in maternal plasma.
Ng EKO, Tsui NBY, Lau TK, Leung TN, Chiu Rossa WK, Panesar NS, Lit LCW, Chan KW, Lo DYM
Proc Natl Acad Sci USA 2003;100(8): 4748 - 4753
83Pitfalls in diagnosis of interstitial pregnancy.
Chan Louis YS, Fok AWY, Yuen PM
Acta Obstet Gyn Scan 2003;82(9): 867 - 870
84Quantifying F2-isoprostanes in umbilical cord blood of newborn by gas chromatography-mass spectrometry.
Chu KO, Wang CC, Rogers MS, Pang CCP
Anal Biochem 2003;316(1): 111 - 117
85Relationship between umbilical cord morphology and nuchal cord entanglement.
Rogers MS, Ip Wan Yim, Qin Y, Rogers SM, Sahota DS
Acta Obstet Gyn Scan 2003;82(1): 32 - 37
86Repeated courses of antenatal corticosteroids: Is it justified?
Leung TN, Lam PM, Ng PC, Lau TK
Acta Obstet Gyn Scan 2003;82(7): 589 - 596
87Updated gestational age specific birth weight, crown-heel length, and head circumference of Chinese newborns.
Fok TF, So HK, Wong E, Ng PC, Chang AMZ, Lau JTF, Chow CB, Lee WH
Arch Dis Child Fetal Neonatal Ed 2003;88(3): F229 - F236
88A comparison of fetal behaviour in term fetuses exposed to anticonvulsant medication with unexposed controls.
Kean LH, , Gargari SS, Suwanrath C, Sahota DS, James DK
BJOG 2001;108(11): 1159 - 1163
89Circulating fetal RNA in maternal plasma.
Poon LLM, Leung TN, Lau TK, Lo DYM
Ann NY Acad Sci 2001;945: 207 - 210
90Computerized analysis of acute and chronic changes in fetal heart rate variation and fetal activity in association with maternal smoking.
Coppens M, Vindla S, James DK, Sahota DS
Am J Obstet Gynecol 2001;185(2): 421 - 426
91Influences of perinatal factors on cord blood thyroid-stimulating hormone level.
Chan Louis YS, Leung TN, Lau TK
Acta Obstet Gyn Scan 2001;80(11): 1014 - 1018
92Multilevel modeling of fetal and placental growth using echo-planar magnetic resonance imaging.
Duncan KR, Sahota DS, Gowland PA, Moore R, Chang AMZ, Baker PN, Johnson IR
J Soc Gynecol Investig 2001;8(5): 285 - 290
93Oxidative stress in the fetal lamb brain following intermittent umbilical cord occlusion: a path analysis.
Rogers MS, Murray HGS, Wang CC, Pennell CE, Turner A, Ping Y, Pang CCP, Chang AMZ
BJOG 2001;108(12): 1283 - 1290
94Rate of rise in maternal plasma corticotrophin-releasing hormone and its relation to gestational length.
Leung TN, Chung TKH, Madsen G, Lam PKW, Sahota DS, Smith R
BJOG 2001;108(5): 527 - 532
95Relationship between birthweight and repeated courses of antenatal corticosteroids.
Lam PM, Yuen PM, Lau TK, Leung TN
Aust NZ J Obstet Gyn 2001;41(3): 281 - 284
96Analysis of mid-trimester corticotrophin-releasing hormone and alpha-fetoprotein concentrations for predicting pre-eclampsia.
Leung TN, Chung TKH, Madsen G, Lam CWK, Lam PKW, Walters WAW, Smith R
Hum Reprod 2000;15(8): 1813 - 1818
97Determinants of umbilical cord arterial 8-iso-prostaglandin F2alpha concentrations.
Qin Y, Wang CC, Kuehn H, Rathmann J, Pang CP, Rogers MS
BJOG 2000;107(8): 973 - 981
98Development of a customised birthweight standard for ethnic Chinese subjects.
Pang MW, Leung TN, Sahota DS, Lau TK, Chang AMZ
Aust NZ J Obstet Gyn 2000;40(2): 161 - 164
99A Comparison of fetal Behaviour in breech and cephalic presentations at term.
Kean LH, Suwanrath C, Gargari SS, Sahota DS, James DK
BJOG 1999;106(11): 1209 - 1213
100Comparison of unstimulated and stimulated behaviour in human fetuses with congenital abnormalities.
Vindla S, James DK, Sahota DS
Fetal Diagn Ther 1999;14: 156 - 165
101Elevated mid-trimester maternal corticotrophin-releasing hormone levels in pregnancies that delivered before 34 weeks.
Leung TN, Chung TKH, Madsen G, McLean M, Chang AMZ, Smith R
BJOG 1999;106: 1041 - 1046
102Fetal and maternal level of lipid peroxides in term pregnancies.
Rogers MS, Mongelli JM, Tsang BKH, Wang CC
Acta Obstet Gyn Scan 1999;78(2): 120 - 124
103Hyperemesis gravidarum, transient hyperthyroxinaemia ad primary hyperparathyroidism in a Chinese woman.
Li JKY, Yeung VTF, Chow CC, Ko GTC, Lau TK, Cockram CS
Aust NZ J Med 1999;29(3): 379 - 380
104Intapartum fetal hypoxia-reperfusion injury and oligohydramnios: a comparison of three ultrasound estimate of amniotic fluid volume.
Rogers MS, Wang CC
Ultrasound Obst Gyn 1999;12(1): 161
105Emergency cervical cerclage. A study between duration of cerclage in situ with gestation at cerclage, herniation of forewater and cervical dilatation at presentation.
Yip SK, Fung HYM, Fung TY
Eur J Obstet Gyn R B 1998;78(1): 63 - 67
106Exposure to angiotensin-converting enzyme inhibitors during first trimester: is it safe to fetus?
Yip SK, Leung TN, Fung HYM
Acta Obstet Gyn Scan 1998;77: 570 - 571
107Computerised analysis of behaviour in fetuses with congenital abnormalities.
Vindla S, Sahota DS, Coppens M, James DK
Ultrasound Obst Gyn 1997;9: 302 - 309
108Computerised analysis of behaviour in normal and growth-retarded fetuses.
Vindla S, James DK, Sahota DS, Coppens M
Eur J Obstet Gyn R B 1997;75(199): 169 - 175
109Computerised Analysis of Fetal Behaviour.
Vindla S, Sahota DS, Coppens M, James DK
Fetal Diagn Ther 1997;12: 319 - 327
110Fetal diagphragmatic hernia presented with transient unilateral pleural effusion.
Lau TK, Fung HYM, Fung TY
Ultrasound Obst Gyn 1997;9(2): 125 - 127
111Intra-uterine growth retardation and transverse lie due to massive subchorionic thrombohematoma and overlying subchorionic cyst.
Tam WH, Fung HYM, Fung TY, Lau TK, To KF
Acta Obstet Gyn Scan 1997;76(4): 381 - 383
112Lipid peroxidation in cord blood: a footprint of free oxygen radical activity.(Suppl)
Rogers MS, Wang VW, Wang CC, Chang AMZ
Acta Obstet Gyn Scan 1997;167(1): 20
113Lipid peroxide in cord blood: a randomized sequential pairs study of prophylactic saline amnioinfusion for intrapartum oligohydramnios.
Wang CC, Rogers MS
BJOG 1997;104(10): 1145 - 1151
114Lipid peroxide in cord blood: the effect of amniotic fluid volume.
Wang CC, Rogers MS
BJOG 1997;104(10): 1140 - 1144
115Pregnancy outcome beyond 41 weeks gestation.
Roach VJ, Rogers MS
Int J Gynecol Obstet 1997;59(1): 19 - 24
116Transvaginal sonographic assessment of cervical dynamics during the third trimester of normal pregnancy.
Brieger GM, Ning XH, Dawkins RR, Ying KQ, Weng C, Chang AMZ, Haines CJ
Acta Obstet Gyn Scan 1997;76: 118 - 122
117Urinary D-Glucaric Acid Excretion in Idiopathic Neonatal Jaundice. (Chinese Article)
Sung RYT, Pang CP, Lyon A, Loong EPL, Davies DP
Chin Med J 1997;109: 201 - 205
118Birth weight from pregnancies dated by ultrasonography in a multicultural British population.
Wilcox MA, Gardosi JO, Mongelli JM, Ray C, Johnson IR
Brit Med J 1996;307: 588 - 591
119Clinical birthweight standards for a total population in the 1980's.
Wilcox MA, Mongelli JM, Gardosi JO
BJOG 1996;101: 178
120A survey of pregnancies that ended in Haemoglobin Bart's hydrops foetalis and Cooley's anaemia.
Leung TN, Li CY, Chang AMZ
Hong Kong Med J 1995;1(3): 273
121Detection of fetal Y-specific DNA from the cervix.
Fung HYM, Wong YF, Haines CJ, Wong FWS
Acta Obstet Gyn Scan 1995;74(4): 248 - 250
122Localized ileal perforation associated with antenatal sulindac and dexamethasone treatment.
Ng PC, Fung HYM, Yeung CK
Pediatr Surg Int 1995; :
123Longitudinal study of fetal growth in subgroups of a low-risk population.
Mongelli JM, Gardosi JO
Ultrasound Obst Gyn 1995;6(5): 340 - 344
124Polyhydramnios and hypercalcemia associated with congenital mesoblastic nephroma.
Fung TY, Fung HYM, Ng PC, Chang AMZ, Yeung CK
Obstet Gynecol 1995;85(5): 815 - 817
125Determinants of birthweight in Vietnamese detainees in Hong Kong.
Rogers MS, Rogers KT
Asia Oceania J Obstet Gynaecol 1994;20: 395 - 400
126Relative macrosomia' identified by the individualised birthweight ratio a better method of identifying the at risk fetus.
Sanderson DA, Wilcox MA, Johnson IR
Acta Obstet Gyn Scan 1994;73: 246 - 249
127Insulin like growth factor binding protein-1, glucose tolerance and fetal growth in human pregnancy.
Baldwin SA, Chung TKH, Rogers MS, Chard T, Wang HS
J Endocrinol 1993;136(2): 319 - 325
128Transvaginal sonography in the management of cervical incompetence.
Chung TKH, Haines CJ, Kong D, Woo WK, Rogers MS
Gynecol Obstet Inves 1993;36(1): 59 - 61
129Ultrasound estimation of fetal weight: precision or guess work.
Rogers MS, Chung TKH, Chang AMZ
Aust NZ J Obstet Gyn 1993;33: 142 - 144
130Customised antenatal growth charts.
Gardosi JO, Kalyan B, Chang AMZ, Sahota DS, Symonds EM
Lancet 1992;339: 283 - 288
131Postpartum thyroid dysfunction.
Learoyd DL, Fung HYM, McGregor AM
Thyroid 1992;2(1): 80
132Improvement in umbilical doppler waveform following steroid administration.
Leung AKL, Neale EJ, Rogers MS
BJOG 1991;98(5): 492
133Perinatal asphyxia: The role of intra-partum monitoring in prediction and prevention.
Rogers MS, Chang AMZ
J Obstet Gynaecol 1991;11: 34 - 40
134Second-trimester thyroid function and pregnancy outcome in mothers with hyperthyroidism. Birth weight related to mid-trimester triiodothyronine and RBC zinc.
Lao TTH, Chin RKH, Mak YT, Swaminathan SR
Gynecol Obstet Inves 1991;32(2): 78 - 80
135Birth-weight of newborns to chinese women subsequent to a previous abortion.
Tan TC, Chang AMZ, Rogers MS
Aust NZ J Obstet Gyn 1990;30: 217 - 221
136Macrosomic babies.
Cheung TH, Leung AKL, Chang AMZ
Aust NZ J Obstet Gyn 1990;30(4): 319 - 322
137Topical prostaglandin E2 gel for cervical ripening and closure of the ductus arteriosus in the newborn.
Sung RYT, Yin JA, Loong EPL, Fok TF, Lau JTF
Arch Dis Child 1990;65: 703 - 704
138Zinc and birth weight in uncomplicated pregnancies.
Lao TTH, Loong EPL, Chin RKH, Lam CWK, Lam YM
Acta Obstet Gyn Scan 1990;69: 609 - 611
139Lower incidence of elevated umbilical cord serum IgE concentration in infants of hepatitis B carrier mothers.
Tseng RYM, Lam CWK, Loong EPL, Ho DWY, Davies DP
Acta Paediatr Scand 1989;78: 127 - 128
140Renal function in the newborn. Newborn creatinine related to birth weight, maturity and maternal creatinine.
Lao TTH, Loong EPL, Chin RKH, Lam YM
Gynecol Obstet Inves 1989;28(2): 70 - 72
141Thyroid function in pre-eclampsia.
Lao TTH, Chin RKH, Swaminathan SR
BJOG 1988;95(9): 880 - 883
142Transient hyperthyroidism in a pregnancy with hydrops fetalis.
Lao TTH, Chin RKH, Chan AC
BJOG 1988;95(6): 624 - 625
143Cretinism and lingual thyroid presenting in an adult.
Yeung VTF, Loong EPL, Cockram CS
Postgrad Med J 1987;63: 881 - 883
144Determinants of birth-weight in the New Territories of Hong Kong.
Rogers MS, Wong FWS, Chang AMZ
Aust NZ J Obstet Gyn 1987;27(4): 314 - 319
145Intestinal parasitism: A survey of patients attending an antenatal clinic in the New Territories of Hong Kong.
Rogers MS, French GL, Chang AMZ
Asia Oceania J Obstet Gynaecol 1987;13: 461 - 466
146Perinatal asphyxia: The use of Path Analysis in its explanation.
Rogers MS, Chang AMZ
J Obstet Gynaecol 1987;8: 29 - 35
147Plasma zinc concentration and thyroid function in hyperemetic pregnancies.
Lao TTH, Chin RKH, Mak YT, Panesar NS
Eur J Obstet Gyn R B 1987;30(2): 117 - 122
148The outcome of hyperemetic pregnancies complicated by transient hyperthyroidism.
Lao TTH, Chin RKH, Chang AMZ
Aust NZ J Obstet Gyn 1987;27(2): 99 - 101
149Umbilical cord serum IgE in infants of hepatitis B carrier mothers.
Loong EPL, Tseng RYM, Lam CWK, Ho DWY, Davies DP
Allergologia et Immunopathologia 1987;15: 239
150The use of a microcomputer in the antenatal interview - a feasibility study.
Wong FWS
HK Pract 1986;8: 1650 - 1656
151Zinc concentration in umbilical cord tissue and cord plasma in appropriate for gestational age babies.
Wong FWS, Arumanayagam M, Chang AMZ, Swaminathan SR
Eur J Obstet Gyn R B 1986;23: 121 - 126
152An evaluation of three ultrasound equations for fetal weight prediction.
Wong FWS, Rogers MS, Chang AMZ
Aust NZ J Obstet Gyn 1985;25: 271 - 272
153Any place for antenatal diagnosis in the third trimester of pregnancy?
Lao TTH, Loong EPL, Yeung SSL
Clin Exp Obstet Gynecol 1985;12(3): 51 - 52
154Evaluation of fundal height measurement inantenatal care.
Rogers MS, Needham PG
Aust NZ J Obstet Gyn 1985;25: 87 - 90
155The limitations of ultrasonography in the antenatal diagnosis of congenital cerebral malformations.
Loong EPL, Lao TTH
Gynecol Obstet Inves 1985;19(3): 166 - 168
156Antenatal diagnosis of intracranial arteriovenous fistula by ultrasonography.
Mao KR, Adams J
BJOG 1983;90(9): 872 - 873