Professor LI Tin Chiu

LI Tin Chiu

Current Position:
Professor

Office Phone:
(852) 3505 2800

Email:
tinchiu.li@cuhk.edu.hk

Qualifications:
MBBS (HK), MD(HK), PhD (Sheffield), FRCOG, FRCP(Glasgow)

Other Positions:

  • Honorary Professor of Reproductive Medicine & Surgery, Sheffield Hallam University
    2004 – now
  • Honorary Professor, Capital University of Medical Sciences, Beijing, China
    2006 – now
  • Honorary Professor, University of Shangdong, Jinan, China
    2012 – now

Professor LI Tin Chiu was until recently Professor of Reproductive Medicine & Surgery in Sheffield, England. He joined The Chinese University of Hong Kong in May 2014 and is currently the Director of Reproductive Medicine & Surgery Programme.  He has a special interest in recurrent miscarriage, implantation failure, reproductive surgery and congenital uterine anomaly. Professor LI is active in clinical and basic research and has published over 250 articles in international journals.  He is the coordinator of the Special Interest Group in Reproductive Surgery of European Society of Human Reproduction & Embryology.

Clinical & research Interests:

  1. Infertility
  2. Recurrent miscarriage
  3. Repeated IVF failure
  4. Fibroid
  5. Endometriosis
  6. Reproductive surgery

Publications: 
Over 250 papers in international refereed journals on various aspects of reproductive surgery, infertility, pregnancy loss, endometrium & implantation prior to joining the department.

Publications prior to joining the department

Publications after joining the department:

1The effect of prednisolone on endometrial uterine NK cell concentrations and pregnancy outcome in women with reproductive failure. A retrospective cohort study
Cooper S, Laird SM, Mariee N, Li TC, Metwally M
J Reprod Immunol.  2019 Feb, Volume 131, Pages 1-6
2Mitochondria Manipulation in Oocytes: A Mini-Review
Zhao M, Li TC, Chan DYL
Int J Obstet Gynaecol Stud. 2017 1(1) :1-5
3Comparative analysis of single-cell parallel sequencing approaches in oocyte application
Qian Y, Liao J, Suen AHC, Lee AWT, Chung CHS, Tang NLS, Chow KL, Cao Q, Yip YL, Leung TY, Chan WY, Chan DYL, Li TC, Lee TL
Int J Biochem Cell Biol. 2019 Feb;107:1-5
4Impact of preimplantation genetic testing for aneuploidy on obstetrical practice
Chan YM, Li TC, Poon LCY
Curr Opin Obstet Gynecol. 2019 Apr;31(2):127-131
5Intrauterine balloon therapy: A novel ultrasound guided treatment for intrauterine adhesions
Saravelos SH,  Li TC
Gynecological Surgery. 2016 Nov; 13(4) 403–407
6Practical Considerations in Providing Preimplantation Genetic Testing for Aneuploidies (PGT-A)
Yeung QSY, Zhang YX, Chung JPW, Kwok YKY, Gui B, Choy KW, Li TC
Fertility and Reproduction, 1(1), May 2019, 1-9
7Clinical outcomes following long GnRHa ovarian stimulation with highly purified human menopausal gonadotropin plus rFSH or rFSH in patients undergoing in vitro fertilization-embryo transfer: a multi-center randomized controlled trial
Shu L, Xu Q, Meng Q, Dai X, Zhang Y, Zhou W, Yi H, Liu J, Wu C, Hou Z, Cui Y, Li TC, Liu J
Ann Transl Med Apr 2019;7(7):146
8Endometrial vascularization characterized by Optical Coherence Tomography and immunohistochemistry in women undergoing in vitro fertilization- embryo transfer treatment
Law SM, Cheung CWC, Wu F, Zhang R, Chung JPW, Wang CC, Chen X, Li TC
Medicina (Kaunas). 2019 Mar 27;55(4), 1-12
9Efficacy, feasibility and patient acceptability of ultrasound-guided manual vacuum aspiration for treating early pregnancy loss
Chung JPW, Chung CHS, Mak JSM, Li TC, Kong GWS
Aust N Z J Obstet Gynaecol. 2019 Feb;59(1):71-76
10Comparison of DNA fragmentation levels in spermatozoa with different sex chromosome complements
Shi X, Chan DYL, Zhao MP, Chan CPS, Huang J, Li TC
Reprod Biomed Online. 2019 Jan;38(1):56-65
11Severe growth restriction undelivered at term and ultrasound examination: Some clarifications
Chung JPW, Li TC
Aust Nz J Obstet Gyn. Oct 2018; 58(5):E14, 1 page
12Intrauterine infusion of human chorionic gonadotropin before embryo transfer in IVF/ET cycle: The critical review
Zhang T, Chen X, Wang CC, Li TC, Kwak KJ
Am J Reprod Immunol. 2018 Dec 27:e13077, 12 pages
13A prospective observational study on the stress levels at the time of embryo transfer and pregnancy testing following in vitro fertilisation treatment: a comparison between women with different treatment outcomes
Cheung CWC, Saravelos SH, Chan TYA, Sahota DS, CC Wang, Chung PW, Li TC
BJOG. 2019 Jan;126(2):271-279
14A systematic comparison of bacterial colonization of endometrial tissue and fluid samples in recurrent miscarriage patients: Implications for future endometrial microbiome studies
Liu Y, Wong KKW, Ko EYL, Chen X, Huang J, Tsui SKW, Li TC, Chim SSC
Clin Chem. 2018 Dec;64(12):1743-1752
15Lifestyle and demographic factors associated with human semen quality and sperm function
Shi X, Chan CPS, Waters T, Chi L, Chan DYL, Li TC
Syst Biol Reprod Med. 2018 Oct;64(5):358-367
16The impact of music therapy on pain and stress reduction during oocyte retrieval – a randomized controlled trial
Cheung CWC, Wong AWY, Chan CPS, Saravelos SH, Chung JPW, Cheung LP, Kong GWS, Li TC
Reprod Biomed Online. 2018 Aug;37(2):145-152
17Increased expression of angiogenic cytokines in CD56+ uterine natural killer cells from women with recurrent miscarriage
Chen X, Liu Y, Cheung WC, Zhao Y, Huang J, Chung JPW, Wang CC, Li TC
Cytokine. 2018 Oct;110:272-276
18Decreased MUC1 in endometrium is an independent receptivity marker in recurrent implantation failure during implantation window
Wu F, Chen X, Liu Y, Liang B, Xu H, Li TC, Wang CC
Reprod Biol Endocrinol. 2018 Jun 21;16(1):60
19The Investigation and Management of Adenomyosis in Women Who Wish to Improve or Preserve Fertility
Li J, Chung JPW, Wang S, Li TC, Duan H
BioMed Research International
20Comparison of the prevalence of chronic endometritis as determined by means of different diagnostic methods in women with and without reproductive failure
Liu Y, Chen X, Huang J, Wang CC, Yu MY, Laird S, Li TC
Fertil Steril. 2018 May;109(5):832-839
21Tradition al and molecular chromosomal abnormality analysis of products of conception in spontaneous and recurrent miscarriage
Zhang T, Sun Y, Chen Z, Li TC
BJOG. 2018 Mar;125(4):414-420
22Pinopode score around the time of implantation is predictive of successful implantation following frozen embryo transfer in hormone replacement cycles
Jin XY, Zhao LJ, Luo DH, Liu L, Dai YD, Hu XX, Wang YY, Lin X, Hong F, Li TC, Zhang SY
Hum Reprod. 2017 Dec 1;32(12):2394-2403
23A comparison of pregnancy outcome of modified transvaginal cervicoisthmic cerclage performed prior to and during pregnancy
Wei M, Jin X, Li TC, Yang C, Huang D, Zhang S
Arch Gynecol Obstet. 2018 Mar;297(3):645-652
24The Therapeutic Effects of a Traditional Chinese Medicine Formula Wuzi Yanzong Pill for the Treatment of Oligoasthenozoospermia: A Meta-Analysis of Randomized Controlled Trials
Zhao M, Shi X, Kong GWS, Wang CC, Wu JCY, Lin Z, Li TC, Chan DYL
Evidence-Based Complementary and Alternative Medicine  Jan 2018 (2968025): 1-10
25Evaluation of the awareness of, attitude to, and knowledge about fertility preservation in cancer patients among clinical practitioners in Hong Kong
Chung JP, Lao TT, Li TC
Hong Kong Med J. 2017 Dec;23(6):556-61
26Prevalence and confounders of chronic endometritis in premenopausal women with abnormal bleeding or reproductive failure
Song D, Feng X, Zhang Q, Xia E, Xiao Y, Xie W, Li TC
Reprod Biomed Online. 2018 Jan;36(1):78-83 
27Serum luteinizing hormone level on the third day after ovarian stimulation in GnRH agonist short protocol is predictive of outcome in poor responders but not in normal responders
Zhu HY, Liu S, He D, Zhou WH, Li TC, Li Y
Gynecol Endocrinol. 2017 Jan;33(1):57-61
28Reproductive Outcome of Transcervical Uterine Incision in Unicornuate Uterus
Xia EL, Li TC, Choi SS, Zhou QY
Chin Med J (Engl). 2017 Feb 5;130(3):256-261.
29The effect of elevated progesterone levels before oocyte retrieval in women undergoing ovarian stimulation for IVF treatment on the genomic profile of peri-implantation endometrium
Liu L, Huang J, Li TC, Hong XT, Laird S, Dai YD, Tong XM, Zhu HY, Zhang S
J Reprod Immunol. 2017 Jun;121:17-25
30Transvaginal, rather than traditional, laparoscopy should be used for the assessment of infertility: AGAINST: Practising specialists prefer traditional laparoscopy
Li TC
BJOG. 2017 Jul;124(8):1207
31Response: rLH versus uHCG supplementation in poor ovarian responders
Kong GWS, Mak JSM, Li TC
Reprod Biomed Online. 2017 Oct;35(4):434
32Effects of Esstradiol at Different Levels on Rabbit Endometrial Repair after Curettage
Zhang Y, Chen F, Li TC, Duan H, Wu Yh
Journal of Reproductive Medicine 2017 Mar-Apr; 62(3-4):138-146
33Validation of a high-throughput and robust technique: BACs-on-beads assay (KaryoLite BoBs) for pre-implantation aneuploidy screening
Kong GWS, Ma Y, Ou J, Kwok YKY, Wang W, Yeung QSY, Wong CKM, Li Q, Xu W, Lu W, Li H, Li TC, Choy KW
Taiwan J Obstet Gynecol. 2017 Aug;56(4):514-520
34Measurement of uterine natural killer cell percentage in the periimplantation endometrium from fertile women and women with recurrent reproductive failure: establishment of a reference range
Chen X, Mariee N, Jiang L, Liu Y, Wang CC, Li TC, Laird S
Am J Obstet Gynecol. 2017 Dec;217(6):680.e1-680.e6
35A prospective, randomized, controlled trial comparing two doses of oestrogen therapy after hysteroscopic adhesiolysis to prevent intrauterine adhesion recurrence
Guo J, Li TC, Liu Y, Xia E, Xiao Y, Zhou F, Yang X
Reprod Biomed Online. 2017 Nov;35(5):555-561
36Expression Pattern of G-Protein-Coupled Estrogen Receptor in Myometrium of Uteri with and without Adenomyosis
Li JJ, Duan H, Wang S, Sun FQ, Gan L, Tang YQ, Xu Q, Li TC
Biomed Research International, 2017 Oct;2017, Article ID 5974693:1-6
37Safety and Efficacy of Amnion Graft in Preventing Reformation of Intrauterine Adhesions
Peng X, Li TC, Zhao Y, Guo Y, Xia E
Journal of Minimally Invasive Gynecology, 2017 Nov;24(7);1204-1210
38The effect of endometrial scratch on natural-cycle cryopreserved embryo transfer outcomes: a randomized controlled study
Mak JSM, Chung CHS, Chung JPW, Kong GWS, Saravelos SH, Cheung LP, Li TC
Reprod Biomed Online. 2017 Jul;35(1):28-36
39Effect of mid-follicular phase recombinant LH versus urinary HCG supplementation in poor ovarian responders undergoing IVF – a prospective double-blinded randomized study
Mak SM, Wong WY, Chung HS, Chung PW, Kong GWS, Li TC, Cheung LP
Reprod Biomed Online. 2017 Mar;34(3):258-266
40Ultrasound-guided treatment of intrauterine adhesions in the outpatient setting
Saravelos SH, Li TC
Ultrasound Obstet Gynecol. 2017 Aug;50(2):278-280
41Effects of high progesterone level on the day of human chorionic gonadotrophin administration in in vitro fertilization cycles on epigenetic modification of endometrium in the peri-implantation period
Xiong YJ, Wang JZ, Liu L, Chen XY, Xu H, Li TC, Wang CC, Zhang SY
Fertil Steril. 2017 Aug;108(2):269-276
42The regulations and role of circadian clock and melatonin in uterine receptivity and pregnancy—An immunological perspective
Man GCW, Zhang T, Chen X, Wang J, Wu F, Liu Y, Wang CC, Cheong Y, Li TC
Am J Reprod Immunol. 2017 Aug;78(2)e12715
43Physiological and pathological angiogenesis in endometrium at the time of embryo implantation
Chen X, Man GCW, Liu Y, Wu F, Huang J, Li TC, Wang CC
Am J Reprod Immunol. 2017 Aug;78(2)e12693
44Correlation between three-dimensional power Doppler and morphometric measurement of endometrial vascularity at the time of embryo implantation in women with unexplained recurrent miscarriage
Chen X, Saravelos SH, Liu Y, Huang J, Wang CC, Li TC.
J Mol Histol. 2017 Jun;48(3):235-242
45A comparison of transcriptomic profiles in endometrium during window of implantation between women with unexplained recurrent implantation failure and recurrent miscarriage
Huang J, Qin H, Yang Y, Chen X, Zhang J, Laird S, Wang CC, Chan TF, Li TC
Reproduction. 2017 Jun;153(6):749-758
46Hepatitis B virus infection status and infertility causes in couples seeking fertility treatment—Indicator of impaired immune response?
Lao TT, Mak JSM, Li TC
Am J Reprod Immunol. 2017 Apr;77(4):e12636
47Assessment of the uterus with three-dimensional ultrasound in women undergoing ART
Saravelos SH, Jayaprakasan K, Ojha K, Li TC
Hum Reprod Update. Mar 2017;23(2):188-210
48Virtual hysteroscopy with HDlive
Saravelos SH, Li TC
Ultrasound Obstet Gynecol. 2017 Feb;49(2):284-286
49HOXA-10 and E-Cadherin Expression in the Endometrium of Women with Recurrent Implantation Failure and Recurrent Miscarriage
Yang Y, Chen X, Saravelos SH, Liu Y, Huang J, Zhang J, Li TC
Fertility And Sterility Jan;107(1):136-143.E2
50Serum Human Chorionic Gonadotropin Measured 7 Days Following Day 3 Embryo Transfer Might Predict Pregnancy Outcome in IVF
Wang Q, Zhang R, Jia M, Luo L, Ding C, Li TC, Zhou C
Gynecological Endocrinology Jan 2017;33(1):62-66
51The changing pattern of uterine contractions before and after fresh embryo transfer and its relation to clinical outcome
Chung CHS, Wong AWY, Chan CPS, Saravelos SH, Kong G WS, Cheung LP, Chung JPW, Li TC
Reproductive BioMedicine Online Mar 2017;34(3):240-247
52A Prospective Randomized Controlled Trial of 3D versus 2D Ultrasound-guided Embryo Transfer in Women Undergoing ART Treatment.
Saravelos S, Kong GWS, Chung JPW, Mak JSM, Chung CHS, Cheung LP, Li TC
Hum Reprod Oct 2016;31(10): 2255 – 2260
53The Impact of Ovarian Stimulation on the Outcome of Intrauterine Insemination Treatment: An Analysis of 8893 Cycles.
Liu J, Li TC, Wang J, Wang W, Hou Z, Liu J
BJOG Sep 2016;123(3): 70 – 75
54Standardisation of Uterine Natural Killer (uNK) Cell Measurements in the Endometrium of Women with Recurrent Reproductive Failure.
Lash GE, Bulmer JN, Li TC, Innes BA, Mariee N, Patel G, Sanderson J, Quenby S, Laird SM
J Reprod Immunol Aug 2016;116(2016): 50 – 59
55Endometrial Thickness as a Predictor of Pregnancy Outcomes in 10787 Fresh IVF-ICSI Cycles.
Yuan X, Saravelos S, Wang Q, Xu Y, Li TC, Zhou C
Reprod Biomed Online Aug 2016;33(2): 197 – 205
56Incidence of Interstitial Pregnancy after In Vitro Fertilization/Embryo Transfer and the Outcome of a Consecutive Series of 38 Cases Managed by Laparoscopic Cornuostomy or Cornual Repair.
Wang J, Huang D, Lin X, Saravelos S, Chen J, Zhang X, Li TC, Zhang S
J Minim Invasive Gynecol Jul 2016;23(5): 739 – 747
57How Often Does the Embryo Implant at the Location to Which It Was Transferred?
Saravelos S, Wong AWY, Chan CPS, Kong GWS, Li TC
Ultrasound Obst Gyn Jul 2016;48(1): 106 – 112
58Simplified Laparoscopic Cervical Cerclage after Failure of Vaginal Suture: Technique and Results of a Consecutive Series of 100 Cases
Huang X, Ma N, Li TC, Guo Y, Song D, Zhao Y, Xia E
Eur J Obstet Gyn R B Jun 2016;201(2016): 146 – 150
59Pain during Embryo Transfer is Independently Associated with Clinical Pregnancy in Fresh/Frozen Assisted Reproductive Technology Cycles.
Saravelos S, Wong AWY, Kong GWS, Huang J, Klitzman R, Li TC
J Obstet Gynaecol Res Jun 2016;42(6): 684 – 693
60The Incidence of Post-operative Adhesion following Transection of Uterine Septum: A Cohort Study Comparing Three Different Adjuvant Therapies.
Xiao Y, Liu Y, Song D, Xia E, Li TC
Eur J Obstet Gyn R B Jun 2016;(201): 61 – 64
61Hypoxia Inducible Factor and Microvessels in Peri-implantation Endometrium of Women with Recurrent Miscarriage.
Chen XY, Jiang LM, Wang CC, Huang J, Li TC
Fertil Steril Jun 2016;105(6): 1496 – 1502
62Intra-Cycle Variation of the Uterine Cavity Indentation Assessed with Three-Dimensional Ultrasound in Natural and Stimulated Cycles.
Saravelos S, Li TC
Reprod Biomed Online May 2016;32(5): 545 – 550
63Effects of Mechanical Stresses on Sperm Function and Fertilization Rate in Mice.
Shi X, Wang T, Qiu ZL, Li L, Li L, Chan CPS, Chan SM, Li TC, Quan S
Syst Biol Reprod Med Apr 2016;62(2): 152 - 159
64Assessment of the Embryo Flash Position and Migration with Three-dimensional Ultrasound within 60 Minutes of Embryo Transfer.
Saravelos S, Wong AWY, Chan CPS, Kong GWS, Cheung LP, Chung CHS, Chung JPW, Li TC
Hum Reprod Mar 2016;31(3): 591 – 596
65The Thessaloniki ESHRE/ESGE Consensus on Diagnosis of Female Genital Anomalies.
Grimbizis GF, Di Spiezio Sardo A, Saravelos S, Gordts S, Exacoustos C, Van Schoubroeck D, Bermejo C, Amso NN, Nargund G, Timmermann D, Athanasiadis A, Brucker S, De Angelis C, Gergolet M, Li TC, Tanos V, Tarlatzis B, Farquharson R, Gianaroli L, Campo R.
Gynecol Surg Feb 2016;13(1): 1 – 16
66The Thessaloniki ESHRE/ESGE Consensus on Diagnosis of Female Genital Anomalies.
Grimbizis GF, Di Spiezio Sardo A, Saravelos S, Gordts S, Exacoustos C, Van Schoubroeck D, Bermejo C, Amso NN, Nargund G, Timmermann D, Athanasiadis A, Brucker S, De Angelis C, Gergolet M, Li TC, Tanos V, Tarlatzis B, Farquharson R, Gianaroli L, Campo R.
Hum Reprod Jan 2016;31(1): 2 – 7i
67Monochorionic Quadramniotic and Triamniotic Pregnancies following Single Embryo Transfers: Two Case Reports and a Review of the Literature.
Saravelos S, Zhang T, Chung JPW, Sun LM, Sun Y, Li TC, Chen ZJ
J Assist Reprod Gen Jan 2016;33(1): 27 - 32
68Management of False Passage Created during Hysteroscopic Adhesiolysis for Asherman Syndrome.
Song D, Xia E, Xiao Y, Li TC, Huang X, Liu Y
J Obstet Gynaecol Jan 2016;36(1): 87 - 92
69Fertility Preservation in Young Female Cancer Patients.
Chung JPW, Kong GWS, Li TC
MIMS Journal of Paediatrics, Obstetrics & Gynaecology Jan 2016;42(1): 24 - 31
70A Comparison of Pattern of Pregnancy Loss in Women with Infertility Undergoing IVF and Women with Unexplained Recurrent Miscarriages Who Conceive Spontaneously.
Tamhankar VA, Liu B, Yan J, Li TC
Obstetrics and Gynecology International 2015;2015: 1 - 6
71Comparison of Progesterone Measurement on Day of, And Day After, HCG Administration in IVF-Embryo Transfer Cycles.
Liu L, Zhao L, Li TC, Zhu H, Lin X, Jin X, Tong X, Zhang S
Reprod Biomed Online 2015;30(2): 157 - 165
72Differential Expression of Vascular Endothelial Growth Factor Angiogenic Factors in Different Endometrial Compartments in Women Who Have an Elevated Progesterone Level before Oocyte Retrieval, during in Vitro Fertilization¡Vembryo Transfer Treatment.
Chen XY, Jin XY, Liu L, Man GCW, Huang J, Wang CC, Zhang S, Li TC
Fertil Steril 2015;104(4): 1030 - 1036
73Intra- and Inter-observer Variability of Uterine Measurements with Three-dimensional Ultrasound and Implications for Clinical Practice.
Saravelos S, Li TC
Reprod Biomed Online 2015;31(4): 557 - 564
74Randomized, Controlled Trial Comparing the Efficacy of Intrauterine Balloon and Intrauterine Contraceptive Device in the Prevention of Adhesion Reformation after Hysteroscopic Adhesiolysis.
Lin X, Zhou F, Wei M, Yang Y, Li Y, Li TC, Zhang S
Fertil Steril 2015;104(1): 235 - 240
75Salpingectomy and Proximal Tubal Occlusion for Hydrosalpinx Prior to In Vitro Fertilization: A Meta-Analysis of Randomized Controlled Trials.
Zhang Y, Sun Y, Guo YS, Li TC, Duan H
Obstet Gynecol Surv 2015;70(1): 33 - 38
76Surgical Management of Tubal Disease and Infertility.
Kong GWS, Li TC
Obstetrics, Gynaecology & Reproductive Medicine 2015;25(1): 6 - 11
77The Effect of a High Progesterone Concentration before Oocyte Retrieval on the Peri-implantation Endometrium.
Liu L, Sailan S, Li TC, Mariee N, Laird S, Jiang Z, Zhang S
Reprod Biomed Online 2015;31(6): 739 - 746
78The Impact of Endometrioma on IVF/ICSI Outcomes: A Systematic Review and Meta-analysis.
Hamdan M, Dunselman G, Li TC, Cheong Y
Hum Reprod Update 2015;21(6): 809 - 825
79A Comparison of the Miscarriage Rate between Women with and without Polycystic Ovarian Syndrome Undergoing IVF Treatment.
Liu L, Tong X, Jiang L, Li TC, Zhou F, Zhang S
Eur J Obstet Gyn R B 2014;176(2014): 178 - 182
80A Matched Cohort Study Comparing the Outcome of Intrauterine Adhesiolysis for Asherman Syndrome after Uterine Artery Embolization or Surgical Trauma.
Song D, Liu Y, Xiao Y, Li TC, Zhou F, Xia E
J Minim Invasive Gynecol 2014;21(6): 1022 - 1028