Professor CHIM Siu Chung, Stephen
(852) 3505 1324
Our team has a keen interest in developing non-invasive markers for predicting preterm birth, a major contributor to neonatal morbidity and mortality. Globally, over 13 million babies were born preterm (birth before 37 gestational weeks) each year. Many fetal organ systems, including the brain and lungs, need the final 3 weeks of pregnancy to develop fully. Thus, the early preterm birth <34 weeks is associated with poor neonatal outcomes, including respiratory distress syndrome, intraventricular hemorrhage, long-term neurological disabilities and even neonatal death. It is estimated that 10 neonates die per minute world-wide as a result of preterm birth. Better prediction of preterm birth in women without preterm labor (asymptomatic) and with preterm labor (symptomatic) is a vital step to improving the management of this condition.
We have leveraged on the technological breakthrough brought forth by massively parallel sequencing (MPS). MPS has enabled us to explore the microbiomes and transcriptomes at an unprecedentedly high resolution and wide scope for markers. Clinically useful markers in maternal peripheral blood or in the female reproductive tract swab samples have been identified with promising potential to predict:
- spontaneous preterm birth after clinical intervention on women who are asymptomatic but at high-risk for preterm birth;
- spontaneous preterm birth among the symptomatic women.
Multi-centre studies pertinent to the further characterisation and development of these markers in different ethnic groups are underway.
Non-invasive markers for predicting preterm birth in asymptomatic and symptomatic women
Summary of research output:
- Total number of paper published = 38
- H-index = 19
- Sum of the times cited = 1844 (without self-citations, 1798)
- Average citation per paper = 48.53 (without self-citations, 47.32)
|1||Endometrial microbiota in infertile women with and without chronic endometritis as diagnosed using a quantitative and reference range-based method
Liu Y, Ko EYL, Wong KKW, Chen X, Cheung CWC, Law SM, Chung JPW, Tsui SKW, Li TC, Chim SSC
Fertil Steril. 2019 Oct;112(4):707-717
|2||A systematic comparison of bacterial colonization of endometrial tissue and fluid samples in recurrent miscarriage patients: Implications for future endometrial microbiome studies
Liu Y, Wong KKW, Ko EYL, Chen X, Huang J, Tsui SKW, Li TC, Chim SSC
Clin Chem. 2018 Dec;64(12):1743-1752
|3||Systematic Selection of Reference Genes for the Normalization of Circulating RNA Transcripts in Pregnant Women Based on RNA-Seq Data
Chim SSC, Wong KKW, Chung CYL, Lam SKW, Kwok JSL, Lai CY, Cheng YKY, Hui ASY, Meng M, Chan OK, Tsui SKW, Lee KY, Chan TF, Leung TY
Int J Mol Sci. 2017 Aug 4;18(8): E1709.
|4||Potential application of fetal epigenetic markers on the non-invasive prenatal detection of chromosomal abnormality.
Clin Chem Lab Med 2014;52(5): 585 - 588
|5||Proteomic Analysis Reveals Platelet Factor 4 and Beta-thromboglobulin as Prognostic Markers in Severe Acute Respiratory Syndrome.
Poon TCW, Pang RTK, Chan AKC, Lee NLS, Chiu RWK, Tong YK, Chim SSC, Ngai SSM, Sung JJY, Lo DYM
Electrophoresis 2012;33(12): 1894 - 1900
|6||Systematic Identification of Spontaneous Preterm Birth-Associated RNA Transcripts in Maternal Plasma.
Chim SSC, Lee WS, Ting YH, Chan OK, Lee SWY, Leung TY
PLos ONE 2012;7(4): e34328
|7||CHD5 Downregulation Associated with Poor Prognosis in Epithelial Ovarian Cancer.
Wong RRY, Chan LKY, Tsang PT, Lee CWS, Cheung TH, Yim SF, Siu NSS, Lee SNC, Yu MMY, Chim SSC, Wong YF, Chung TKH
Gynecol Obstet Inves 2011;72(3): 203 - 207
|8||Epigenetic Regulation of Neonatal Cardiomyocytes Differentiation.
Kou CYC, Lau SLY, Au KW, Leung PY, Chim SSC, Fung KP, Waye MMY, Tsui SKW
Biochem Bioph Res Co 2010;400(2): 278 - 283
|9||Systematic Identification of Placental Epigenetic Signatures for the Noninvasive Prenatal Detection of Edwards Syndrome.
Tsui DWY, Lam DYM, Lee CWS, Leung TY, Lau TK, Lau ET, Tang MHY, Akolekar R, Nicolaides KH, Chiu RWK, Lo DYM, Chim SSC
PLos ONE 2010;5(11): e15069
|10||Role of monoamine oxidases in the exaggerated 5-hydroxytryptamine-induced tension development of human isolated preeclamptic umbilical artery.
Seto SW, Lam HY, Lau WS, Au ALS, Lam TY, Chim SSC, Ngai SSM, Chan SW, Leung TY, Yeung JHK, Kong SK, Leung GPH, Lee SMY, Kwan YW
Eur J Pharmacol 2009;605(1-3): 129 - 137
|11||Hypermethylation of RASSF1A in Human and Rhesus Placentas.
Chiu Rossa WK, Chim SSC, Wong IHN, Wong CSC, Lee CWS, To KF, Tong JHM, Yuen KC, Shum ASW, Chan JKC, Chan LYS, Yuen WF, Tong YK, Weier JF, Ferlatte C, Leung TN, Lau TK, Lo KW, Lo DYM
Am J Pathol 2007;170(3): 941 - 950
|12||Modulation by simvastatin of iberiotoxin-sensitive, Ca2+-activated K+ channels of porcine coronary artery smooth muscle cells.
Seto SW, Au ALS, Lam TY, Chim SSC, Lee SMY, Wan S, Tjiu DCS, Shigemura N, Yim APC, Chan SW, Tsui SKW, Leung GPH, Kwan YW
Brit J Pharmacol 2007;151(7): 987 - 997
|13||Quantitative aberrations of hypermethylated RASSF1A gene sequences in maternal plasma in pre-eclampsia.
Tsui DWY, Chan AKC, Chim SSC, Chan LW, Leung TY, Lau TK, Lo DYM, Chiu Rossa WK
Prenatal Diag 2007;27(13): 1212 - 1218
|14||Reply to "STOX1 is not imprinted and is not likely to be involved in preeclampsia".
Van Dijk M, Van Bezu J, Chim SSC, Lo DYM, Blankenstein MA, Oudejans CBM
Nat Genet 2007;39(3): 280 - 281
|15||Calcyclin binding protein promotes DNA synthesis and differentiation in rat neonatal cardiomyocytes.
Au KW, Kou CYC, Woo AYH, Chim SSC, Fung KP, Cheng CHK, Waye MMY, Tsui SKW
J Cell Biochem 2006;98(3): 555 - 566
|16||A simple and rapid approach for screening of SARS-coronavirus genotypes: an evaluation study.
Chung GTY, Chiu Rossa WK, Cheung JLK, Jin Yongjie, Chim SSC, Chan PKS, Lo DYM
BMC Infect Dis 2005;5: 87
|17||Detection of the placental epigenetic signature of the maspin gene in maternal plasma.
Chim SSC, Tong YK, Chiu Rossa WK, Lau TK, Leung TN, Chan LYS, Oudejans CBM, Ding CM, Lo DYM
Proc Natl Acad Sci USA 2005;102(41): 14753 - 14758
|18||Systematic micro-array based identification of placental mRNA in maternal plasma: towards non-invasive prenatal gene expression profiling.
Tsui NBY, Chim SSC, Chiu Rossa WK, Lau TK, Ng EKO, Leung TN, Tong YK, Chan AKC, Lo DYM
J Med Genet 2004;41(6): 461 - 467